CDDO-EA
- CAS No.
- 932730-51-3
- Chemical Name:
- CDDO-EA
- Synonyms
- TP319;TP 319;RTA405;TP-319);CDDO-EA;RTA 405;RTA-405;CS-1305;CDDO ethyl amide;Bardoxolone ethyl amide
- CBNumber:
- CB52705078
- Molecular Formula:
- C33H46N2O3
- Molecular Weight:
- 518.73
- MDL Number:
- MFCD11983136
- MOL File:
- 932730-51-3.mol
CDDO-EA price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb611797 | CDDO-EA | 932730-51-3 | 10mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611797 | CDDO-EA | 932730-51-3 | 50mg | $1802 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611797 | CDDO-EA | 932730-51-3 | 100mg | $2512.6 | 2021-12-16 | Buy |
| Crysdot | CD31000205 | CDDO-EA 98+% | 932730-51-3 | 5mg | $245 | 2021-12-16 | Buy |
| Crysdot | CD31000205 | CDDO-EA 98+% | 932730-51-3 | 10mg | $350 | 2021-12-16 | Buy |
CDDO-EA Chemical Properties,Uses,Production
Biological Activity
CDDO-EA is a NF-E2-related factor 2/antioxidant response element (Nrf2/ARE) activator.
in vitro
CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. It is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS.
in vivo
The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%).
target
Nrf2/ARE
CDDO-EA Preparation Products And Raw materials
Raw materials
Preparation Products
CDDO-EA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3421 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| Cckinase, Inc. | +1 (732)236-3202 | sales@cckinase.com | United States | 2738 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |