MF 438
- CAS No.
- 921605-87-0
- Chemical Name:
- MF 438
- Synonyms
- MF 438;Stearoyl-CoA Desaturase (SCD),inhibit,MF438,MF 438,MF-438,Inhibitor;3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine;2-methyl-5-[6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl]-1,3,4-thiadiazole;Pyridazine, 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]-;3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine(MF-438)
- CBNumber:
- CB52716285
- Molecular Formula:
- C19H18F3N5OS
- Molecular Weight:
- 421.44
- MDL Number:
- MFCD28386313
- MOL File:
- 921605-87-0.mol
| Boiling point | 614.5±65.0 °C(Predicted) |
|---|---|
| Density | 1.365±0.06 g/cm3(Predicted) |
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 2 mg/ml with warming). |
| form | solid |
| pka | 2.29±0.10(Predicted) |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| FDA UNII | HI3FN320OX |
MF 438 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0009306 | MF-438 99.92% | 921605-87-0 | 5mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0009306 | MF-438 99.92% | 921605-87-0 | 10mg | $380 | 2021-12-16 | Buy |
| ChemScene | CS-0009306 | MF-438 99.92% | 921605-87-0 | 50mg | $1150 | 2021-12-16 | Buy |
| ChemScene | CS-0009306 | MF-438 99.92% | 921605-87-0 | 100mg | $1650 | 2021-12-16 | Buy |
| DC Chemicals | 020466 | MF-438 | 921605-87-0 | 003 | $1800 | 2021-12-16 | Buy |
MF 438 Chemical Properties,Uses,Production
Description
MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) – IC50?= 2.3 nM.1?MF-438 was potent in an?in vivo?mouse liver PD assay (ED50?between 1 and 3 mg/kg).1?Cancer initiating cells (CSC-like) were shown to be much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2?MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.
References
1) Leger?et al. (2010),?Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438); Bioorg. Med. Chem. Lett.,?20?499 2) Noto?et al. (2013),?Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells; Cell Death and Differ.,?4?e947 3) Rodriguez-Perez?et al.?(2017),?Altered fatty acid metabolism and reduced stearoyl-coenzyme A desaturase activity in asthma; Allergy,?72?1744 [Citation]
MF 438 Preparation Products And Raw materials
Raw materials
Preparation Products
MF 438 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Beijing Yisiyan Technology Research Center | 010-56645598 13366904824 | bjkaida@163.com | China | 1666 | 59 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Zhengzhou Alfachem Co.,Ltd. | 0371-53778726 18003825608 | liuxiaoyan@alfachem.cn | China | 1944 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |