Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)
- CAS No.
- 1246298-62-3
- Chemical Name:
- Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)
- Synonyms
- Kdo2-Lipid A;Kdo2-Lipid A (KLA);Kdo2-Lipid A ammonium;Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt);DI[3-DEOXY-D-MANNO-OCTULOSONYL]-LIPID A (AMMONIUM SALT);KDO2-LIPID A;Di[3-deoxy-D-manno-octulosonyl]-lipid A sodium salt - 0.5mg/ml aqueous solution;O-3-Deoxy-alpha-D-altro-2-octulopyranosonosyl-(2-4)-O-3-deoxy-alpha-D-altro-2-octulopyranosonosyl-(2-6)-O-2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxododecyl)oxy]tetradecyl]amino]-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-4-O-phosphono-beta-D-glucopyranosyl-(1-6)-2-deoxy-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-alpha-D-glucopyranose 1-(dihydrogen phosphate) 3-[(3R)-3-hydroxytetradecanoate] ammonium salt (1:4)
- CBNumber:
- CB52719776
- Molecular Formula:
- C110H214N6O39P2
- Molecular Weight:
- 2306.840482
- MDL Number:
- MFCD22416704
- MOL File:
- 1246298-62-3.mol
- MSDS File:
- SDS
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) price More Price(7)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML2430 | Kdo2-Lipid A (KLA) ≥90% (HPLC) | 1246298-62-3 | 1mg | $193 | 2024-03-01 | Buy |
Usbiological | 044977 | Kdo2-Lipid A | 1246298-62-3 | 1mg | $375 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 108090 | Di[3-deoxy-D-manno-octulosonyl]-lipidAsodiumsalt-0.5mg/mlindoubledistilledwater | 1246298-62-3 | 1mg | $759 | 2021-12-16 | Buy |
Biosynth Carbosynth | OD29173 | Di[3-deoxy-D-manno-octulosonyl]-lipid A sodium salt - 0.5mg/ml aqueous solution | 1246298-62-3 | 1mg | $995 | 2021-12-16 | Buy |
Biosynth Carbosynth | OD29173 | Di[3-deoxy-D-manno-octulosonyl]-lipid A sodium salt - 0.5mg/ml aqueous solution | 1246298-62-3 | 2mg | $1940 | 2021-12-16 | Buy |
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Chemical Properties,Uses,Production
Uses
Kdo2-Lipid A (KLA) is a nearly homogeneous Re lipopolysaccharide (LPS) substracture with endotoxin activity equal to tha of native LPS. KLA is comparable to LPS and its activity is reduced by >10^3 in cells fro TLR-4 deficient mice.
Uses
Kdo2-Lipid A (KLA) has been used:
- as a toll like receptor (TLR) ligand source in immortalized murine macrophage culture media
- in 2H-,13C-,15N-labeled OprHΔL1ΔL4 in 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC) micelles, to determine the specific residues of OprHΔL1ΔL4 interacting with lipopolysaccharides (LPS) source
- as a component of LPS stock to study its role in lipopolysaccharide induced prion protein conversion
General Description
3-deoxy-D-manno-octulosonic acid (Kdo2-Lipid A) is the essential component of lipopolysaccharide in most Gram-negative bacteria and the minimal structural component to sustain bacterial viability. It serves as the active component of lipopolysaccharide to stimulate potent host immune responses through the complex of Toll-like-receptor 4 (TLR4) and myeloid differentiation protein 2 (MD2). Therefore, Kdo2-lipid A is an important stimulator for studying the mechanism of the innate immune system and for developing bacterial vaccine adjuvants. Kdo2 Lipid A/TLR4 antagonists can also be applied in anti-inflammatory interventions. Kdo2-lipid A, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. Kdo2-Lipid A has been used in animal atherosclerosis model.
Biochem/physiol Actions
Kdo2-Lipid A might be useful to stimulate inflammatory response.
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Preparation Products And Raw materials
Raw materials
Preparation Products
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Codow Chemical Co.,Ltd. | 18620099427 | amy@howeipharm.com | China | 17698 | 55 |
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Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |
Beijing Minruida Technology Co., Ltd. | 010-82387566 18001021521; | sales@mreda.com.cn | China | 21450 | 58 |
BOC Sciences | 16314854226 | inquiry@bocsci.com | United States | 9713 | 58 |
Supplier | Advantage |
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BOC Sciences | 58 |
Creative Enzymes | 58 |
Sigma-Aldrich | 80 |
Codow Chemical Co.,Ltd. | 55 |
Chengdu Dianchun Technology Co., Ltd | 60 |
Beijing Solarbio Science & Tecnology Co., Ltd. | 68 |
Beijing Minruida Technology Co., Ltd. | 58 |
BOC Sciences | 58 |