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UMI-77

UMI-77 Structure
UMI-77 structure
CAS No.
518303-20-3
Chemical Name:
UMI-77
Synonyms
UMI-77;CS-1799;UMI 77;UMI77;UMI-77 USP/EP/BP;Bcl-2 Family,UMI-77,Inhibitor,inhibit;2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid;2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid;Acetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-;2-[4-[(4-Bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid UMI-77
CBNumber:
CB52729658
Molecular Formula:
C18H14BrNO5S2
Molecular Weight:
468.34
MDL Number:
MFCD03471890
MOL File:
518303-20-3.mol
Last updated:2023-06-08 09:02:36
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UMI-77 Properties

Boiling point 661.2±65.0 °C(Predicted)
Density 1.79±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥23.4 mg/mL in DMSO; insoluble in H2O; ≥7.2 mg/mL in EtOH
form solid
pka 2.41±0.30(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

UMI-77 price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19148 UMI-77 ≥98% 518303-20-3 1mg $32 2024-03-01 Buy
Cayman Chemical 19148 UMI-77 ≥98% 518303-20-3 5mg $93 2024-03-01 Buy
Cayman Chemical 19148 UMI-77 ≥98% 518303-20-3 10mg $169 2024-03-01 Buy
Usbiological 468454 UMI-77 518303-20-3 1mg $382 2021-12-16 Buy
TRC U700850 UMI-77 518303-20-3 1mg $100 2021-12-16 Buy
Product number Packaging Price Buy
19148 1mg $32 Buy
19148 5mg $93 Buy
19148 10mg $169 Buy
468454 1mg $382 Buy
U700850 1mg $100 Buy

UMI-77 Chemical Properties,Uses,Production

Uses

UMI-77 acts as a small molecule inhibitor of Mcl-1 which blocks and attenuates pancreatic cell cancer growth. Anticancer agent.

Biological Activity

umi-77 is a novel small-molecule inhibitor of mcl-1 with ki and ic50 values of 0.49 μm and 0.31 μm [1].myeloid cell leukemia-1 (mcl-1) is a member of the prosurvival bcl-2 family and is a potent anti-apoptotic protein. mcl-1 acts as an important survival factor in a broad range of human cancers [1].umi-77 is a novel small-molecule mcl-1 inhibitor. in fp-based binding assays, umi-77 potently and selectively displaced fluorescent labeled bid-bh3 peptide from mcl-1 protein with ki value of 0.49μm and bound to the bh3 binding pocket of mcl-1 protein. umi-77 bound to a1/bfl-1, bcl-w, bcl-2 and bcl-xl with ki values of 5.33, 8.19, 23.83 and 32.99μm. in a pull-down assay, umi-77 at 10 μm effectively and dose-dependently inhibited the interactions between bl-noxa and cellular mcl-1. it was reported that mcl-1 regulates pro-apoptotic bax and bak proteins and preventing their pro-apoptotic activity. umi-77 dose-dependently inhibited the binding of mcl-1 to bax with ic50 value of 1.43μm. in pc cells, umi-77 inhibited cell growth and induced apoptosis in a time and dose-dependent way [1].in bxpc-3 xenografted scid mice model, umi-77 exhibited robust anti-tumor efficacy with no toxicity. also, umi-77 decreased the anti-apoptotic protein survivin, which potently inhibited apoptosis by antagonizing caspase activity [1].

References

[1]. abulwerdi f, liao c, liu m, azmi as, et al. a novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo. mol cancer ther, 2014, 13(3): 565-575.

UMI-77 Preparation Products And Raw materials

Raw materials

Preparation Products

UMI-77 Suppliers

Global( 83)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29016 58
Shenzhen Shengda Pharma Limited 		755-85269922 +8613424394241 sales@shengdapharm.com CHINA 310 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Supplier Advantage
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Dideu Industries Group Limited 		58
Shenzhen Shengda Pharma Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58

View Lastest Price from UMI-77 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Acetic acid, 2-?[[4-?[[(4-?bromophenyl)?sulfonyl]?amino]?-?1-?hydroxy-?2-?naphthalenyl]?thio]?- pictures 2020-01-02 Acetic acid, 2-?[[4-?[[(4-?bromophenyl)?sulfonyl]?amino]?-?1-?hydroxy-?2-?naphthalenyl]?thio]?-
518303-20-3
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co

UMI-77 Spectrum

UMI-77(518303-20-3)1HNMR

518303-20-3(UMI-77)Related Search:

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ABT 263

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2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid UMI-77 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid 2-[4-[(4-Bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid UMI-77 Acetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]- UMI 77;UMI77 CS-1799 UMI-77 USP/EP/BP Bcl-2 Family,UMI-77,Inhibitor,inhibit 518303-20-3 Inhibitors API