INDY
- CAS No.
- 1169755-45-6
- Chemical Name:
- INDY
- Synonyms
- INDY;(1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone;(1Z)-1-(3-Ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)acetone;(1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one;(Z)-1-(3-Ethyl-5-hydroxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one;2-Propanone, 1-(3-ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-, (1Z)-
- CBNumber:
- CB52748091
- Molecular Formula:
- C12H13NO2S
- Molecular Weight:
- 235.3
- MDL Number:
- MFCD28100814
- MOL File:
- 1169755-45-6.mol
- MSDS File:
- SDS
INDY price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1011 | INDY ≥98% (HPLC) | 1169755-45-6 | 5mg | $103 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1011 | INDY ≥98% (HPLC) | 1169755-45-6 | 25mg | $334 | 2024-03-01 | Buy |
| Cayman Chemical | 23895 | INDY ≥98% | 1169755-45-6 | 1mg | $30 | 2024-03-01 | Buy |
| Cayman Chemical | 23895 | INDY ≥98% | 1169755-45-6 | 5mg | $75 | 2024-03-01 | Buy |
| Cayman Chemical | 23895 | INDY ≥98% | 1169755-45-6 | 10mg | $134 | 2024-03-01 | Buy |
INDY Chemical Properties,Uses,Production
Description
INDY is an ATP-competitive inhibitor of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A; Ki = 180 nM; IC50 = 240 nM). It is selective for DYRK1A over monoamine oxidase (MAO) A and B at concentrations up to 100 μM. INDY inhibits DYRK1A phosphorylation of tau in COS-7 cells expressing EGFP-DYRK1A and EGFP-tau in a concentration-dependent manner. It also restores signaling through nuclear factory of activated T cells (NFAT) and NFAT-dependent transcription in HEK293 cells overexpressing DYRK1A. In vivo, INDY reverses developmental deformities induced by DYRK1A overexpression in X. laevis embryos. INDY also induces proliferation of human and rat β-cells and increases insulin secretion by human islets in vitro.
Uses
INDY is a dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A/B (DYRK1A/B) inhibitor (1,2).
storage
-20°C
INDY Preparation Products And Raw materials
Raw materials
Preparation Products
INDY Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| Guangzhou Zhiya Chemdrugs Co.,Ltd | 18122150900 | sculk28@163.com | China | 647 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| TaiChem Taizhou Limited | 052386810091 | zcwy9518@yeah.net | China | 3871 | 58 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-021-20242659 18930833303 | order@changyanchem.com | China | 5008 | 55 |