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ChemicalBook >> CAS DataBase List >>N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester

N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester

N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester Structure
N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester structure
CAS No.
1401089-31-3
Chemical Name:
N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester
Synonyms
PACMA 31;PACMA 31 >=98% (HPLC);N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester;Glycine, N-(2,4-dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-, ethyl ester;bond,tumor,ovarian,athymic,PACMA31,inhibit,toxicity,colony,PACMA-31,mice,PACMA 31,oral,Inhibitor,covalent
CBNumber:
CB52750694
Molecular Formula:
C21H22N2O6S
Molecular Weight:
430.47
MDL Number:
MFCD26793891
MOL File:
1401089-31-3.mol
MSDS File:
SDS
Last updated:2023-09-04 15:50:00
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N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester Properties

storage temp. room temp
solubility DMSO: soluble10mg/mL, clear (warmed)
form powder
color white to light brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
NFPA 704
0
2 0

N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0838 PACMA 31 ≥98% (HPLC) 1401089-31-3 5mg $127 2024-03-01 Buy
Sigma-Aldrich SML0838 PACMA 31 ≥98% (HPLC) 1401089-31-3 25mg $482 2024-03-01 Buy
Tocris 5116 PACMA 31 ≥99%(HPLC) 1401089-31-3 10 $87 2021-12-16 Buy
TRC P132083 PACMA 31 1401089-31-3 1mg $60 2021-12-16 Buy
TRC P132083 PACMA 31 1401089-31-3 5mg $235 2021-12-16 Buy
Product number Packaging Price Buy
SML0838 5mg $127 Buy
SML0838 25mg $482 Buy
5116 10 $87 Buy
P132083 1mg $60 Buy
P132083 5mg $235 Buy

N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester Chemical Properties,Uses,Production

Uses

PACMA 31 is a protein disulfide isomerase family A member 1 (PDIA1) inhibitor as promising target for chemotherapy.

Biochem/physiol Actions

PACMA 31 is an orally bioavailable, selective inhibitor (IC50 = 10 μM) of protein disulfide isomerase (PDI), an endoplasmic reticulum protein that regulates oxidative protein folding by catalyzing the breakage and reformation of disulfide bonds. PDI is upregulated in ovarian, and several other cancers. PACMA 31 dose dependently inhibits proliferation of OVCAR-8 in culture and in a tumor xenograft model.

storage

Store at RT

N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester Suppliers

Global( 31)Suppliers
Supplier Tel Email Country ProdList Advantage
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
ChemeGen 中国 18818260767 sales@chemegen.com China 6975 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 3413 55
Shanghai Han-Xiang Chemical Co., Ltd. 15971444841 amber@biochempartner.com China 3063 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
BOC Sciences -- info@bocsci.com USA 0 65
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9414 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
Supplier Advantage
Career Henan Chemica Co 		58
Aladdin Scientific 		58
ChemeGen 中国 58
Sigma-Aldrich 80
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai Han-Xiang Chemical Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 65
DC Chemicals 58
Energy Chemical 58

N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester Spectrum

N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester(1401089-31-3)1HNMR
N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester PACMA 31 Glycine, N-(2,4-dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-, ethyl ester PACMA 31 >=98% (HPLC) bond,tumor,ovarian,athymic,PACMA31,inhibit,toxicity,colony,PACMA-31,mice,PACMA 31,oral,Inhibitor,covalent 1401089-31-3