N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan
- CAS No.
- 185351-19-3
- Chemical Name:
- N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan
- Synonyms
- NQTrp;NQTrp >=98% (HPLC);1,4-Naphthoquinon-2-yl-l-tryptophan;N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan;L-Tryptophan, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-;(S)-2-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)-3-(1H-indol-3-yl)propanoic acid
- CBNumber:
- CB52751095
- Molecular Formula:
- C21H16N2O4
- Molecular Weight:
- 360.36
- MDL Number:
- MFCD21496345
- MOL File:
- 185351-19-3.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1104 | NQTrp ≥98% (HPLC) | 185351-19-3 | 5mg | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1104 | NQTrp ≥98% (HPLC) | 185351-19-3 | 25mg | $476 | 2024-03-01 | Buy |
| Cayman Chemical | 19127 | NQTrp ≥98% | 185351-19-3 | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 19127 | NQTrp ≥98% | 185351-19-3 | 5mg | $94 | 2024-03-01 | Buy |
| Cayman Chemical | 19127 | NQTrp ≥98% | 185351-19-3 | 10mg | $140 | 2024-03-01 | Buy |
N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan Chemical Properties,Uses,Production
Description
NQTrp is an inhibitor of Alzheimer’s disease-associated amyloid β (Aβ) oligomerization and fibrillization (IC50 = 50 nM for formation of fibrils from Aβ1-42). It has been shown to reduce the cytotoxic effect of Aβ oligomers in a cultured neuronal cell line.
Uses
NQTrp is a inhibitor of Aβ1-42 aggregation, altering Aβ self-assembly and reducing toxicity.
References
[1]. scherzer-attali r, pellarin r, convertino m, et al. complete phenotypic recovery of an alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor. plos one. 2010 jun 14;5(6):e11101.
[2]. zhang t, xu w, mu y, et al. atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-l-tryptophan inhibitor on alzheimer's aβ1-42 dimer in terms of aggregation and toxicity. acs chem neurosci. 2014 feb 19;5(2):148-59.
N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan Preparation Products And Raw materials
Raw materials
Preparation Products
N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9748 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| Jingmo (Xiamen) Biotechnology Co., Ltd | 13621943973 13515979683 | sales@jamxmpharmatech.com | China | 1079 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |