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Cefonicid

Cefonicid
Cefonicid structure
CAS No.
61270-58-4
Chemical Name:
Cefonicid
Synonyms
Monocid;Cefodie;Pratled;SKF-75073;Monocidur;CEFONICID;7-beta(r*)))-;amino)-8-oxo-3-(((1-sulfomethyl)-1h-tetrazol-5-yl)thio)methyl)-,(6r-(6-alpha,;(6R,7R)-7α-[[(R)-Hydroxyphenylacetyl]amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(7r)-7-(2-hydroxy-2-phenylacetylamino)-6-oxo-3-{[1-(sulfomethyl)(1,2,3,4-tetraazol-5-ylthio)]methyl}-2h,7h,7ah-azetidino[2,1-b]1,3-thiazine-4-carboxylic acid
CBNumber:
CB5283109
Molecular Formula:
C18H18N6O8S3
Formula Weight:
542.57
MOL File:
61270-58-4.mol

Cefonicid Properties

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Cefonicid Chemical Properties,Uses,Production

Uses

A semi-synthetic cephalosporin antibiotic related to Cefamandole. Antibacterial

Definition

ChEBI: A cephalosporin bearing {[1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl}methyl and (R)-2-hydroxy-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.

Antimicrobial activity

Activity against Gram-positive and Gram-negative organisms in vitro is depressed by the presence of 50% serum. It is highly bound to plasma protein (98%) and has an extended plasma half-life of 4.5–5 h. A 1 g intramuscular dose achieves a mean peak plasma concentration of around 83 mg/L. Following a 1 g intravenous bolus dose, mean peak plasma concentrations of 130–300 mg/L have been reported. In patients treated for community-acquired pneumonia, concentrations of 2–4 mg/L have been found in sputum.
It is predominantly excreted by renal secretion, 83–89% being recovered unchanged in the urine over 24 h. Plasma half-life is linearly related to creatinine clearance. As a result of its high protein binding it is not removed by hemodialysis.
It is generally well tolerated; pain on injection, rash and positive Coombs’ test are reported in some patients. It has been used to treat respiratory, soft tissue and urinary infections. Available in Italy.

Cefonicid Preparation Products And Raw materials

Raw materials

Preparation Products


Cefonicid Suppliers

Global( 45)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12343 58
Cheng Du Micxy Chemical Co.,Ltd 028-85632863 028-64559668 18048500443
028-85632863 QQ: 2509670926 micxysales@163.com China 13076 58
Nanjing Sunlida Biological Technology Co., Ltd. 025-58378339;025-57798810
025-57019371 sales@sunlidabio.com China 3823 55
Shanghai Kewel Chemical Co., Ltd. +86 (21) 6460-9169
+86 (21) 6460-9160 kewelchemexp@yahoo.com China 9818 50
Hangzhou J&H Chemical Co., Ltd. +86-0571-87396432
+86-0571-87396431 sales@jhechem.com China 13902 53
Shandong XiYa Chemical Industry Co., Ltd 4008-626-111
0539-6365991 3229735657@qq.com China 26793 60
Raw material medicin reagent co.,Ltd 025-57798860
sales@njromanme.com China 4620 58
Shandong Ono Chemical Co., Ltd. 0539-6362799(To 20)
0539-6362799(To 20) 861669111@qq.com China 10006 58

61270-58-4(Cefonicid)Related Search:


  • 7-beta(r*)))-
  • amino)-8-oxo-3-(((1-sulfomethyl)-1h-tetrazol-5-yl)thio)methyl)-,(6r-(6-alpha,
  • CEFONICID
  • (7r)-7-(2-hydroxy-2-phenylacetylamino)-6-oxo-3-{[1-(sulfomethyl)(1,2,3,4-tetraazol-5-ylthio)]methyl}-2h,7h,7ah-azetidino[2,1-b]1,3-thiazine-4-carboxylic acid
  • (6R,7R)-7-[[(2R)-2-Hydroxy-2-phenylacetyl]amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
  • [6R-[6α,7β(R^<*>^)]]-7- [(2-Hydroxy-2-phenylacetyl)amino]-3-[(1-sulfomethyl-1H-tetrazol-5-y1)tlfiomethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-enr2-carboxylic acid
  • Cefodie
  • Monocid
  • Monocidur
  • Pratled
  • SKF-75073
  • (6R,7R)-7α-[[(R)-Hydroxyphenylacetyl]amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 61260-58-4
  • C18H16N6O8S3Na2
  • 61270-58-4
  • API
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • C18H18N6O8S3
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