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PURVALANOL A

PURVALANOL A structure

CAS No.: 212844-53-6

Chemical Name:: PURVALANOL A

Synonyms: NG-60;PurvaL;CH61386;CS-1631;PURVALANOL A;CDKinhibitor;(R)-Purvalanol A;NG 60;NG60;NG-60;PURVALANOLA, >98%;PurvalanolA/CH61386

CBNumber:: CB5283664

Molecular Formula:: C19H25ClN6O

Molecular Weight:: 388.89

MDL Number:: MFCD02179211

MOL File:: 212844-53-6.mol

Last updated:2023-06-30 15:45:59

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PURVALANOL A Properties

Boiling point	590.5±60.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	methylene chloride: 50 mg/mL, clear, colorless
form	powder
pka	14.51±0.10(Predicted)
color	off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
FDA UNII	YP483E75C4

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P271-P261-P280
WGK Germany	3
HS Code	2933599590

PURVALANOL A price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	540500	Purvalanol A	212844-53-6	1mg	$113	2024-03-01	Buy
Sigma-Aldrich	P4484	Purvalanol A ≥98% (HPLC), powder	212844-53-6	1mg	$144	2023-06-20	Buy
Cayman Chemical	14579	Purvalanol A ≥98%	212844-53-6	5mg	$32	2024-03-01	Buy
Cayman Chemical	14579	Purvalanol A ≥98%	212844-53-6	10mg	$61	2024-03-01	Buy
Cayman Chemical	14579	Purvalanol A ≥98%	212844-53-6	50mg	$275	2024-03-01	Buy

Product number	Packaging	Price	Buy
540500	1mg	$113	Buy
P4484	1mg	$144	Buy
14579	5mg	$32	Buy
14579	10mg	$61	Buy
14579	50mg	$275	Buy

PURVALANOL A Chemical Properties,Uses,Production

Description

Purvalanol A (212844-53-6) is a cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1?Reversibly arrests synchronized cells in G1 and G2 phase.2?Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3?Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4?In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5?Cell permeable.

Uses

Purvalanol A acts as a potent, cell-permeable CDK inhibitor used in the treatment of cell proliferative disorders. Anti-cancer.

Definition

ChEBI: Purvalanol A is a purvalanol.

Biological Activity

Cyclin-dependent kinase inhibitor. IC 50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.

storage

Store at +4°C

References

1) Gray?et al.?(1998),?Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors; Science,?281?533 2) Villerbu?et al.?(2002),?Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities; Int. J. Cancer,?97?761 3) Coker-Gurkan?et al.?(2015),?Purvalanol induces endoplasmic reticulum stress-mediated apoptosis and autophagy in a time dependent manner in HCT116 colon cancer cells; Oncol. Rep.,?33?2761 4) Hikita?et al.?(2010),?Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src; Genes Cells,?15?1051 5) Goga?et al.?(2007),?Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC; Nat. Med.,?13?820

PURVALANOL A Preparation Products And Raw materials

Raw materials

Preparation Products

PURVALANOL A Suppliers

Global( 97)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29474	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9571	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Aladdin Scientific	58

View Lastest Price from PURVALANOL A manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-09-06	PURVALANOL A 212844-53-6	US $1.00 / KG	1KG	98%	20kg	Career Henan Chemical Co

PURVALANOL A
212844-53-6
US $1.00 / KG
98%
Career Henan Chemical Co

PURVALANOL A Spectrum

PURVALANOL A(212844-53-6)¹HNMR

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2-Aminopurine 6-ANILINOPURINE PURVALANOL A

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PURVALANOL A NG-60 6-(3-CHLOROANILINO)-2(1R)-ISOPROPYL-2-HYDROXYETHYLAMINO-9-ISOPROPYLPURINE (2R)-2-[[6-[(3-CHLOROPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL 2-(1R-ISOPROPOYL-2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE 2-(1R-ISOPROPYL-2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYL-PURINE CH61386 2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanolCDKinhibitor. PurvalanolA,CDKinhibitor CDKinhibitor PurvalanolA/CH61386 Purvalanol A(NG 60) (R)-Purvalanol A (R)-2-(6-(3-chlorophenylamino)-9-isopropyl-9H-purin-2-ylamino)-3-methylbutan-1-ol NG-60, 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine Purvalanol A - CAS 212844-53-6 - Calbiochem NG 60;NG60;NG-60 CS-1631 PURVALANOLA, >98% PurvaL 1-Butanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)- PURVALANOL A USP/EP/BP (2R)-2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol 212844-53-6 C19H25ClN6O BioChemical Cell Biology Cell Signaling and Neuroscience Cell Cycle Regulators Cell Cycle Apoptosis and Cell Cycle Inhibitors Signalling