POLYGODIAL
- CAS No.
- 6754-20-7
- Chemical Name:
- POLYGODIAL
- Synonyms
- Poligodial;POLYGODIAL;(-)-Tadeonal;Polygodial (Tadeonal);Drim-7-ene-11,12-dial;1,4,4A,5,6,7,8,8A-Octahydro-5,5,8A-trimethyl-1,2-naphthalenedicarboxaldehyde;(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde;1,2-Naphthalenedicarboxaldehyde, 1alpha,4,4aalpha,5,6,7,8,8A-octahydro-5,5,8abata-trimethyl-;1,2-Naphthalenedicarboxaldehyde, 1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-, (1R,4aS,8aS)-;1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (2R,4as,8as)-
- CBNumber:
- CB5284348
- Molecular Formula:
- C15H22O2
- Molecular Weight:
- 234.33
- MDL Number:
- MFCD00238664
- MOL File:
- 6754-20-7.mol
- MSDS File:
- SDS
| Melting point | 57° (Barnes, Loder) |
|---|---|
| alpha | D24 -131° (c = 0.96 in ethanol) |
| Boiling point | 330.7±35.0 °C(Predicted) |
| Density | 1.084±0.06 g/cm3(Predicted) |
| RTECS | QJ2850000 |
| storage temp. | -20°C |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| LogP | 3.522 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | 5FAF7T66M7 |
POLYGODIAL price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0049 | Polygodial ≥97% (HPLC) | 6754-20-7 | 10mg | $195 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0049 | Polygodial ≥97% (HPLC) | 6754-20-7 | 50mg | $759 | 2024-03-01 | Buy |
| Alfa Aesar | J67380 | Polygodial, 97% | 6754-20-7 | 5mg | $158 | 2021-12-16 | Buy |
| Cayman Chemical | 14979 | Polygodial ≥98% | 6754-20-7 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 14979 | Polygodial ≥98% | 6754-20-7 | 5mg | $93 | 2024-03-01 | Buy |
POLYGODIAL Chemical Properties,Uses,Production
Description
Polygodial (6754-20-7) is a TRPA1 activator (EC50=400 nM).1?A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons.2
Uses
Polygodial is a naturally occurring antifungal and antinociceptive.
Definition
ChEBI: Polygodial is an aldehyde.
Biochem/physiol Actions
Polygodial is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. Initially painful, polygodial acts as an analgesic by desensitizing sensory neuron. Polygodial also has broad antifungal properties, and is cytotoxic against bacteria and algae.
storage
Store at -20°C
References
1) Escalera et al. (2008), TRPA1 mediates the noxious effects of natural sesquiterpene deterrents; J. Biol. Chem., 283 24136 2) Andre et al. (2004), Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdehydes unsaturated sesquiterpenes polygodial and drimanial in rats; Neuropharmacology, 46 590
POLYGODIAL Preparation Products And Raw materials
Raw materials
Preparation Products
POLYGODIAL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Nanjing Digger Medical Technology Co. Ltd. | 025-025-51191215 18013836722 | 2399235533@qq.com | China | 4933 | 58 |