D-1-N-BOC-PROLINAMIDE
- CAS No.
- 70138-72-6
- Chemical Name:
- D-1-N-BOC-PROLINAMIDE
- Synonyms
- 2-carbamoyL;D-N-BOC-PROLINAMIDE;1-BOC-D-PROLINAMIDE;N-ALPHA-BOC-D-PROLINEAMIDE;(Tert-Butoxy)Carbonyl D-Pro-NH2;(R)-2-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Pyrrolidinecarboxylicacid, 2-(aminocarbonyl)-, 1,1-dimethy...;(2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester;1-Pyrrolidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2R)-
- CBNumber:
- CB5284601
- Molecular Formula:
- C10H18N2O3
- Molecular Weight:
- 214.26
- MDL Number:
- MFCD03419274
- MOL File:
- 70138-72-6.mol
| Product description | Number | Pack Size | Price |
| (R)-tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate 95+% | 075206 | 1g | $14 |
| D-N-Boc-prolinamide | U909 | 1g | $21 |
| (R)-tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate 95+% | 075206 | 5g | $36 |
| D-N-Boc-prolinamide | J53342 | 5g | $37 |
| (R)-tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate 95+% | 075206 | 10g | $66 |
| More product size | |||
| Melting point | 100-102 °C |
|---|---|
| Boiling point | 370.1±31.0 °C(Predicted) |
| Density | 1.155±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 15.97±0.20(Predicted) |
| Appearance | White to off-white Solid |
| CAS DataBase Reference | 70138-72-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H319 |
| Precautionary statements | P280-P305+P351+P338 |
D-1-N-BOC-PROLINAMIDE price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 075206 | (R)-tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate 95+% | 70138-72-6 | 1g | $14 | 2021-12-16 | Buy |
| AK Scientific | U909 | D-N-Boc-prolinamide | 70138-72-6 | 1g | $21 | 2021-12-16 | Buy |
| Matrix Scientific | 075206 | (R)-tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate 95+% | 70138-72-6 | 5g | $36 | 2021-12-16 | Buy |
| AK Scientific | J53342 | D-N-Boc-prolinamide | 70138-72-6 | 5g | $37 | 2021-12-16 | Buy |
| Matrix Scientific | 075206 | (R)-tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate 95+% | 70138-72-6 | 10g | $66 | 2021-12-16 | Buy |
D-1-N-BOC-PROLINAMIDE Chemical Properties,Uses,Production
Synthesis
37784-17-1
70138-72-6
General procedure for the synthesis of tert-butyl (R)-2-carbamoylpyrrolidine-1-carboxylate from Boc-D-proline: Example 1; Synthesis of tert-butyl (R)-2-carbamoylpyrrolidine-1-carboxylate. N-Methylmorpholine (9.85 g, 97.5 mmol) and isobutyl chloroformate (13.3 g, 97.5 mmol) were added to a THF solution (98 mL) of (R)-pyrrolidine-1,2-dicarboxylic acid 1- tert-butyl ester (20.0 g, 92.9 mmol) at -78 °C and stirred for 1 hour. Ammonium hydroxide (58 mL) was slowly added while the reaction system was warmed to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the reaction mixture was partitioned between dichloromethane and water. The organic phase was washed with 1 M HCl, dried over anhydrous sodium sulfate, filtered and concentrated to give the title product (10.8 g, 54%) as a colorless semi-solid.1H NMR (300 MHz, CDCl3): δ (ppm) 5.91-6.13 (m, 1H), 4.17-4.30 (m, 2H), 3.37-3.48 (m, 2H), 2.10- 2.18 (m, 2H), 1.84-1.96 (m, 2H), 1.45 (s, 9H).
References
[1] Patent: US2007/259926, 2007, A1. Location in patent: Page/Page column 9
[2] Tetrahedron, 2009, vol. 65, # 46, p. 9536 - 9541
D-1-N-BOC-PROLINAMIDE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| GL Biochem (Shanghai) Ltd. | +86-021-61263370 +86-18901917034 | CHINA | 3904 | 58 | |
| GL Biochem(Binhai) Ltd. | +86-021-61263370 +8615301650015 | wuqiuyan@glschina.com | China | 2975 | 58 |
| Unipharm pharmaceutical industry Co., Ltd | 536-8266195 +8613953676784 | lee@unipharm-sd.com | China | 1202 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20284 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15126 | 58 |
View Lastest Price from D-1-N-BOC-PROLINAMIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | D-1-N-BOC-PROLINAMIDE
70138-72-6
|
US $100.00 / KG | 1KG | 99% | Customized | Career Henan Chemical Co |
-
- D-1-N-BOC-PROLINAMIDE
70138-72-6
- US $100.00 / KG
- 99%
- Career Henan Chemical Co
