Ethoxyquin
- CAS No.
- 91-53-2
- Chemical Name:
- Ethoxyquin
- Synonyms
- eq;Ethoxiquin;emq;Santoflex;ethoxyquine;ETMDQ;niflex;amea100;niflexd;antageaw
- CBNumber:
- CB5296077
- Molecular Formula:
- C14H19NO
- Molecular Weight:
- 217.31
- MDL Number:
- MFCD00023883
- MOL File:
- 91-53-2.mol
| Product description | Number | Pack Size | Price |
| Ethoxyquin ≥75% (capillary GC) | E8260 | 100g | $85.78 |
| Ethoxyquin Pharmaceutical Secondary Standard; Certified Reference Material | PHR3513 | 500 mg | $312 |
| Ethoxyquin PESTANAL , analytical standard | 31519 | 250mg | $27.9 |
| 6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline [Antioxidant for rubber] >90.0%(GC) | E0237 | 25g | $45 |
| 6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline [Antioxidant for rubber] >90.0%(GC) | E0237 | 500g | $179 |
| More product size | |||
| Melting point | <0°C |
|---|---|
| Boiling point | 123-125°C |
| Density | 1.03 g/mL at 20 °C (lit.) |
| vapor pressure | 0.035Pa at 25℃ |
| refractive index | 1.569~1.571 |
| Flash point | 137 °C |
| storage temp. | 2-8°C |
| solubility | ethanol: 50 mL/L, clear, brown |
| pka | 5.02±0.70(Predicted) |
| form | Liquid |
| color | Yellow to Very Dark Brown |
| Water Solubility | <0.1 g/100 mL at 20 ºC |
| Merck | 14,3753 |
| BRN | 158223 |
| Stability | Stable. Combustible. Incompatible with oxidizing agents, strong acids. Polymerizes if heated. May polymerize upon exposure to light and air. |
| InChIKey | DECIPOUIJURFOJ-UHFFFAOYSA-N |
| LogP | 3.39 |
| CAS DataBase Reference | 91-53-2(CAS DataBase Reference) |
| FDA 21 CFR | 172.140; 177.2600 |
| Substances Added to Food (formerly EAFUS) | ETHOXYQUIN |
| EWG's Food Scores | 4-5 |
| FDA UNII | 9T1410R4OR |
| NIST Chemistry Reference | Quinoline, 6-ethoxy-1,2-dihydro-2,2,4-trimethyl-(91-53-2) |
| EPA Substance Registry System | Ethoxyquin (91-53-2) |
| Pesticides Freedom of Information Act (FOIA) | Ethoxyquin |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 24 | |||||||||
| RIDADR | 3082 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | VB8225000 | |||||||||
| F | 2-8-10 | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29334900 | |||||||||
| Hazardous Substances Data | 91-53-2(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in rats, mice: 1920, 1730 mg/kg (Piul'skaya) | |||||||||
| NFPA 704 |
|
Ethoxyquin price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E8260 | Ethoxyquin ≥75% (capillary GC) | 91-53-2 | 100g | $85.78 | 2025-07-31 | Buy |
| Sigma-Aldrich | PHR3513 | Ethoxyquin Pharmaceutical Secondary Standard; Certified Reference Material | 91-53-2 | 500 mg | $312 | 2025-07-31 | Buy |
| Sigma-Aldrich | 31519 | Ethoxyquin PESTANAL , analytical standard | 91-53-2 | 250mg | $27.9 | 2025-07-31 | Buy |
| TCI Chemical | E0237 | 6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline [Antioxidant for rubber] >90.0%(GC) | 91-53-2 | 25g | $45 | 2025-07-31 | Buy |
| TCI Chemical | E0237 | 6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline [Antioxidant for rubber] >90.0%(GC) | 91-53-2 | 500g | $179 | 2025-07-31 | Buy |
Ethoxyquin Chemical Properties,Uses,Production
Description
Ethoxyquin is used as an antioxidant in animal feed and caused contact dermatitis in a worker at an animal feed mill.
Chemical Properties
Transparent yellow or brown viscous liquid. Discolors and stains badly. Soluble in benzene, gasoline, ether, ethanol, carbon tetrachloride, acetone, dichloroethane, insoluble in water.
Uses
Antioxidant in feed and food; antidegradation agent for rubber.
Uses
Ethoxyquin is an antioxidant used in the preservation of color in chili powder, ground chili, and paprika.
Definition
ChEBI: Ethoxyquin is a quinoline that is 1,2-dihydroquinoline bearing three methyl substituents at position 2, 2 and 4 as well as an ethoxy substituent at position 6. It has a role as a herbicide, an UDP-glucuronosyltransferase activator, a neuroprotective agent, a Hsp90 inhibitor, a genotoxin, a food antioxidant, a geroprotector and an antifungal agrochemical. It is a member of quinolines and an aromatic ether.
General Description
Clear light yellow to dark brown viscous liquid. Discolors and stains badly. Mercaptan-like odor.
Air & Water Reactions
Polymerizes and darkens in color on exposure to light and air. Insoluble in water.
Reactivity Profile
Ethoxyquin may undergo a hazardous polymerization at temperatures above 320° F. Tends to polymerize and darken in color on exposure to light and air. Not compatible with oxidizing agents and with strong acids .
Hazard
Toxic by ingestion.
Fire Hazard
Ethoxyquin is combustible.
Agricultural Uses
Insecticide, Fungicide, Plant growth regulator, Ingredient in other products: Used for preharvest or postharvest preservation of color in apples and pears. It is used as an antioxidant to preserve color in paprika and ground and powdered chili. Ethoxyquin is also a chemical preservative used in animal feed to prevent ingredients from reacting with oxygen and becoming rancid. It has been known to cause birth defects in pet birds and dogs. Not approved for use in EU countries[ 115]. Registered for use in the U.S.
Trade name
CHEMLEY®[C]; DECCOQUIN 305®; EMQ®; EQ®; NIFLEX®; NIX-SCALD®[C]; SANTOFLEX A®; SANTOFLEX AW®; SANTOQUIN®; SANTOQUINE®; STOP-SCALD®
Contact allergens
Ethoxyquin is used as an antioxidant in animal feed and caused contact dermatitis in a worker at an animal feed mill
Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx.
Synthesis
156-43-4
67-64-1
91-53-2
The general procedure for the synthesis of ethoxyquinoline from p-ethoxyaniline and acetone was as follows: 100 kg of p-aminoanisole, 30 kg of the solvent acetic anhydride and 5 kg of the catalyst cuprous chloride were added to the reaction tank and mixed thoroughly. Subsequently, the reaction mixture was heated to 130°C, and the titration rate of acetone was controlled by a rotameter at atmospheric pressure, and a total of 210 kg of acetone was titrated. The reaction lasted for 12 hours, during which the content of ethoxyquinoline in the reaction mixture was determined periodically. When the content of ethoxyquinoline reached 90% or higher, the reaction mixture was cooled to 75°C. Water and unreacted acetone produced during the reaction were recovered by condensation and the acetone was recycled.
Potential Exposure
Quinoline insecticide, fungicide and plant growth regulator. Also and ingredient in other products. Used for preharvest or postharvest preservation of color in apples and pears. It is used as an anti-oxidant to preserve color in paprika and ground and powdered chili. Ethoxyquin also is a chemical preservative used in animal feed to prevent ingredients from reacting with oxygen and becoming rancid. It has been known to cause birth defects in pet birds and dogs
Shipping
UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required
Purification Methods
Purify Ethoxyquin by fractional distillation in vacuo whereby the distillate solidifies to a glass. [Knoevenagel Chem Ber 54 1723, 1730 1921.] The methiodide has m 179o (from EtOH), and the 1-phenylcarbamoyl derivative has m 146-147o (from EtOH). [Beaver et al. J Am Chem Soc 79 1236 1957, Beilstein 21 III/IV 95.]
Incompatibilities
Polymerization can occur on contact with strong light and/or water. Decomposes in temperatures above 150℃. Keep away from oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); strong acids.
Waste Disposal
Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. If allowed, Incineration with effluent gas scrubbing is recommended. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office
References
[1] Heteroatom Chemistry, 2012, vol. 23, # 6, p. 598 - 604
[2] Chemische Berichte, 1921, vol. 54, p. 1723,1730
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 21, p. 5081 - 5085
[4] Patent: CN104961679, 2016, B. Location in patent: Paragraph 0023; 0044-0053
[5] European Journal of Pharmaceutical Sciences, 2018, vol. 118, p. 67 - 79
Ethoxyquin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5251 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8770 | 58 |
| Suzhou Sanyi Polymer Chemical Technology Co., Ltd. | +8615571922873 | 15571922873@163.com | China | 102 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Wuhan Ruichi Technology Co., Ltd | +8613545065237 | admin@whrchem.com | China | 153 | 58 |
| Shaanxi Franta Biotechnology Co., Ltd | +86-13082019107 | admin@flanderff.com | China | 244 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | admin@hbsaisier.cn | China | 1015 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Hebei Longbang Technology Co., LTD | +86-18633929156 | admin@hblongbang.com | China | 972 | 58 |
Related articles
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- Jun 24，2024
View Lastest Price from Ethoxyquin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-11-12 | Ethoxyquin
91-53-2
|
US $120.00 / kg | 1kg | 98% | 1000 | Hebei Junhua Import and Export Co., LTD | |
 |
2025-11-12 | Ethoxyquin
91-53-2
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2025-11-10 | powder Ethoxyquin 66%
91-53-2
|
US $1.00 / PCS | 1PCS | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Ethoxyquin
91-53-2
- US $120.00 / kg
- 98%
- Hebei Junhua Import and Export Co., LTD
-
- Ethoxyquin
91-53-2
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- powder Ethoxyquin 66%
91-53-2
- US $1.00 / PCS
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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