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4-(Hydroxymethyl)phenylboronic acid

4-(Hydroxymethyl)phenylboronic acid structure

CAS No.: 59016-93-2

Chemical Name:: 4-(Hydroxymethyl)phenylboronic acid

Synonyms: AKOS BRN-0115;RARECHEM AH PB 0190;4-Boronobenzyl alcohol;(4-Boronophenyl)methanol;4-(Hydroxymethyl)Phenylboronic;(4-methylolphenyl)boronic acid;4-HydroMethylphenylboronicacid;α-Hydroxy-p-tolueneboronic acid;4-(Hydroxymethyl)phenylboronicaci;(p-HydroxyMethyl)phenylboronic acid

CBNumber:: CB5296916

Molecular Formula:: C7H9BO3

Molecular Weight:: 151.96

MDL Number:: MFCD00792672

MOL File:: 59016-93-2.mol

MSDS File:: SDS

Last updated:2026-01-13 11:23:04

Product description	Number	Pack Size	Price
4-(Hydroxymethyl)phenylboronic acid ≥95%	512338	1g	$44.7
4-(Hydroxymethyl)phenylboronic acid ≥95%	512338	10g	$45.3
4-(Hydroxymethyl)phenylboronic Acid (contains varying amounts of Anhydride)	H1204	1g	$48
4-(Hydroxymethyl)phenylboronic Acid (contains varying amounts of Anhydride)	H1204	5g	$145
4-(Hydroxymethyl)phenylboronic Acid (contains varying amounts of Anhydride)	H1204	25g	$368
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4-(Hydroxymethyl)phenylboronic acid Properties

Melting point	251-256 °C (lit.)
Boiling point	362.0±44.0 °C(Predicted)
Density	1.25±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	8.53±0.10(Predicted)
form	Crystalline Powder
color	White to slightly yellow
PH	4.5 (10g/l, H2O)
Water Solubility	25 g/L
BRN	2831413
InChI	InChI=1S/C7H9BO3/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4,9-11H,5H2
InChIKey	PZRPBPMLSSNFOM-UHFFFAOYSA-N
SMILES	B(C1=CC=C(CO)C=C1)(O)O
CAS DataBase Reference	59016-93-2(CAS DataBase Reference)
UNSPSC Code	12352103
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38

Safety Statements

37/39-26-36

WGK Germany

HazardClass

IRRITANT

HS Code

29319090

Storage Class

11 - Combustible Solids

NFPA 704

	0
2		0

4-(Hydroxymethyl)phenylboronic acid price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	512338	4-(Hydroxymethyl)phenylboronic acid ≥95%	59016-93-2	1g	$44.7	2023-06-20	Buy
Sigma-Aldrich	512338	4-(Hydroxymethyl)phenylboronic acid ≥95%	59016-93-2	10g	$45.3	2023-06-20	Buy
TCI Chemical	H1204	4-(Hydroxymethyl)phenylboronic Acid (contains varying amounts of Anhydride)	59016-93-2	1g	$48	2026-03-19	Buy
TCI Chemical	H1204	4-(Hydroxymethyl)phenylboronic Acid (contains varying amounts of Anhydride)	59016-93-2	5g	$145	2026-03-19	Buy
TCI Chemical	H1204	4-(Hydroxymethyl)phenylboronic Acid (contains varying amounts of Anhydride)	59016-93-2	25g	$368	2026-03-19	Buy

Product number	Packaging	Price	Buy
512338	1g	$44.7	Buy
512338	10g	$45.3	Buy
H1204	1g	$48	Buy
H1204	5g	$145	Buy
H1204	25g	$368	Buy

4-(Hydroxymethyl)phenylboronic acid Chemical Properties,Uses,Production

Chemical Properties

Off-white Cryst

Uses

Reactant involved in the synthesis of biologically active compounds including:

Imidazo[4,5-b]pyrazin-2-ones for use as mTOR kinase inhibitors
Human immunodificiency virus protease inhibitors with activity against resistant viruses

Reactant involved in:

Suzuki coupling reactions
Copper-catalyzed transformation from arylboronic acids in water

Involved in the synthesis of polyurethane containing spindle-type chromophores

Uses

suzuki reaction

Synthesis

87199-17-5

59016-93-2

Sodium borohydride (0.38 g, 11 mmol) was added to a solution of (4-formylphenyl)boronic acid (1.5 g, 11 mmol) in methanol (40 mL) in batches at 0 °C, keeping the temperature at 0 °C and stirring the reaction mixture for 1 hour. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent to give the crude product. The crude product was dissolved in water, cooled to 0-5 °C, and the pH was adjusted to 5 by slowly adding 5% aqueous acetic acid.The precipitated solid was collected by diafiltration and washed with cold water, and dried to give 4-hydroxymethylphenylboronic acid (1.2 g, 80% yield). The product was characterized by 1H NMR (400 MHz, CD3OD): δ 7.72 (d, J=7.2 Hz, 2H), 7.59 (d, J=7.6 Hz, 2H), 7.35-7.30 (m, 2H), 4.60 (s, 2H); Mass Spectrometry (ES+): m/z 542.15,544.35 [M+H]; LCMS retention time: tR = 2.42 min.

References

[1] Patent: WO2015/81280, 2015, A1. Location in patent: Paragraph 00689; 00698; 00699
[2] Patent: US5827887, 1998, A
[3] Dyes and Pigments, 2012, vol. 92, # 3, p. 982 - 987
[4] Organic and Biomolecular Chemistry, 2014, vol. 12, # 30, p. 5781 - 5788
[5] Patent: US6576789, 2003, B1

4-(Hydroxymethyl)phenylboronic acid Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid Nickel Tetrahydrofuran Ethylene glycol Triisopropyl borate

4-Bromobenzaldehyde n-Butyllithium 4-Formylphenylboronic acid Methanol Sodium borohydride

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Preparation Products

GSK2190915 (sodiuM salt) 3-IODOBENZYL ALCOHOL 4,4'-Bis(hydroxymethyl)biphenyl (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol p-(phenylthio)benzyl alcohol

3-(5-Cyanopyridin-3-yl)benzyl alcohol [4-(1H-IMIDAZOL-4-YL)-PHENYL]-METHANOL 4-(3-Fluorophenyl)benzyl alcohol 4-(5-Fluoro-2-pyridinyl)benzeneMethanol 2-(3-Hydroxymethylphenyl)thiophene-3-carboxylic acid

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4-(Hydroxymethyl)phenylboronic acid Suppliers

Global( 409)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13815	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29821	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Cangzhou Wanyou New Material Technology Co.,Ltd	18631714998	sales@czwytech.com	CHINA	904	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shanghai Arbor Chemical Co., Ltd.	58
Accela ChemBio Inc.	58
Cangzhou Wanyou New Material Technology Co.,Ltd	58

View Lastest Price from 4-(Hydroxymethyl)phenylboronic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-25	4-(Hydroxymethyl)phenylboronic acid 59016-93-2	US $34.00-1.20 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-05-23	4-(Hydroxymethyl)phenylboronic acid 59016-93-2	US $10.00 / kg	1kg	99%	20 ton	Hebei Zhuanglai Chemical Trading Co Ltd
2025-04-04	4-(Hydroxymethyl)phenylboronic acid 59016-93-2	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.

4-(Hydroxymethyl)phenylboronic acid
59016-93-2
US $34.00-1.20 / kg
99%
Henan Fengda Chemical Co., Ltd

4-(Hydroxymethyl)phenylboronic acid
59016-93-2
US $10.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co Ltd

4-(Hydroxymethyl)phenylboronic acid
59016-93-2
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

4-(Hydroxymethyl)phenylboronic acid Spectrum

4-(Hydroxymethyl)phenylboronic acid(59016-93-2)¹HNMR 4-(Hydroxymethyl)phenylboronic acid(59016-93-2)IR

59016-93-2(4-(Hydroxymethyl)phenylboronic acid)Related Search:

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Methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (4-BENZYLOXYCARBONYLPHENYL)BORONIC ACID (2-AMINO-4-METHOXYCARBONYLPHENYL)BORONIC ACID HYDROCHLORIDE 3-Ethoxycarbonylphenylboronic acid 4-Carboxy-3-fluorophenylboronic acid

4-ISOPROPOXYCARBONYLPHENYLBORONIC ACID METHYL 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE 3,5-DIFLUORO-4-(HYDROXYMETHYL)PHENYLBORONIC ACID

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α-Hydroxy-p-tolueneboronic acid (4-methylolphenyl)boronic acid 4-(HydroxyMethyl)phenylboronic acid, 95+% 4-(HYDROXYMETHYL)PHENYLBORONIC ACID 4-(HYDROXYMETHYL)BENZENEBORONIC ACID (4-Boronophenyl)methanol AKOS BRN-0115 4-(Hydroxymethyl)Phenylboronic 4-Boronobenzyl alcohol 4-(Hydroxymethyl)phenylboronic Acid (contains varying amounts of Anhydride) (p-HydroxyMethyl)phenylboronic acid alpha-Hydroxy-p-tolueneboronic acid B- [4-(HydroxyMethyl)phenyl]boronic acid 4-HydroMethylphenylboronicacid RARECHEM AH PB 0190 4-(Hydroxylmethyl)phenylboronic acid 4-(Hydroxymethyl)phenylboronic acid,97% 4-(Hydroxymethyl)phenylboronic acid ,98% 4-(HydroxyMethyl)phenylboronic acid, 97% 1GR 4-(HydroxyMethyl)phenylboronic acid, 97% 5GR 4-(Hydroxymethyl pPhenylboronic Acid 4-(Hydroxymethyl)benzeneboronic acid 97+% 4-(Hydroxymethyl)phenylboronicaci 59016-93-2 Boronic Acids Boronic Acids and Derivatives Organometallic Reagents Aryl blocks BoronicAcids Boronic Acid series B (Classes of Boron Compounds) Aryl Organoborons Substituted Boronic Acids Boronic acids Heterocyclic Compounds Boronic Acid Boronic Acids Boronic Acids and Derivatives bc0001