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Diethylenetriaminepentaacetic acid

Diethylenetriaminepentaacetic acid
Diethylenetriaminepentaacetic acid structure
Chemical Name:
Diethylenetriaminepentaacetic acid
Molecular Formula:
Formula Weight:
MOL File:

Diethylenetriaminepentaacetic acid Properties

Melting point:
219-220 °C(lit.)
Boiling point:
517.84°C (rough estimate)
refractive index 
1.5700 (estimate)
Flash point:
200 °C
storage temp. 
0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
pK1:;pK2:2.55(+1);pK3:4.33(+2);pK4:8.60(-3);pK5,10.58 (25°C)
Crystalline Powder
White to almost white
2-3 (H2O, 20℃)(saturated solution)
Water Solubility 
5 g/L (20 ºC)
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
67-43-6(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
Glycine, N,N-bis[2-[bis(carboxymethyl) amino]ethyl]-(67-43-6)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,N,Xn
Risk Statements  36-51/53-36/37/38-20-63
Safety Statements  26-36-61-37/39-36/37
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  MB8205000
HazardClass  9
PackingGroup  III
HS Code  29224995
Toxicity LD50 orally in Rabbit: > 2000 mg/kg
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P391 Collect spillage. Hazardous to the aquatic environment
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P501 Dispose of contents/container to..…

Diethylenetriaminepentaacetic acid price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 32319 Diethylenetriaminepentaacetic acid for complexometry, ≥99.0% 67-43-6 100g-f $57.7 2018-11-20 Buy
Sigma-Aldrich 1505506 Pentetic acid United States Pharmacopeia (USP) Reference Standard 67-43-6 100mg $348 2018-11-13 Buy
TCI Chemical D0504 Diethylenetriaminepentaacetic Acid >98.0%(T) 67-43-6 25g $17 2018-11-22 Buy
TCI Chemical D0504 Diethylenetriaminepentaacetic Acid >98.0%(T) 67-43-6 500g $57 2018-11-22 Buy
Alfa Aesar A10926 Diethylenetriaminepentaacetic acid, 98+% 67-43-6 250g $35.3 2018-11-13 Buy

Diethylenetriaminepentaacetic acid Chemical Properties,Uses,Production

Chemical Properties


Chemical Properties

Pentetic acid occurs as a white crystalline solid and is almost odorless.


chelating agent, diagnostic aid


Diethylenetriaminepentaacetic Acid is a component of manganese and zinc fertilizers.

Production Methods

Pentetic acid is a pentaacetic acid triamine formed during the preparation of the amino carboxylic acid and its salt.

Pharmaceutical Applications

Pentetic acid is mainly used as a chelating agent in the preparation of imaging and contrast agents for radionuclide and magnetic resonance imaging.It is also used as a carrier excipient for neutron-capture isotopes in, for example, radiotherapy.Pentetic acid–isotope complexes have also been considered as model active substances in scintigraphic imaging studies.Pentetic acid has been used to chelate metal ions to reduce formation of reactive oxygen species during lyophilization.

Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.


Pentetic acid is used in intrathecal and intravenous injection preparations. The pure form of pentetic acid is moderately toxic by the intraperitoneal route.
LD50 (mouse, IP): 0.54 g/kg
LD50 (mouse, oral): 4.84 g/kg


The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.

Purification Methods

Crystallise DTPA from water. Dry under vacuum or at 110o. [Bielski & Thomas J Am Chem Soc 109 7761 1987, NMR: Wenzel et al. Anal Chem 54 615 1982, Beilstein 4 IV 2454.]


The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.

Regulatory Status

Included in the FDA Inactive Ingredients Database (intrathecal and intravenous injections). Included in intravenous and intra-articular injections licensed in the UK.

Diethylenetriaminepentaacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Diethylenetriaminepentaacetic acid Suppliers

Global( 238)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21967 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32457 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1730 55
+86-571-8723 8903
+86-571-87063838 CHINA 998 58
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114 CHINA 6374 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24001 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 4669 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651 CHINA 925 58
career henan chemical co
+86-371-86658258 CHINA 20104 58

View Lastest Price from Diethylenetriaminepentaacetic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-23 Diethylenetriaminepentaacetic acid
US $2.00 / kg 1kg 9% 100kg career henan chemical co
2018-11-06 best price white powder Diethylenetriaminepentaacetic acid
US $1.00 / KG 1KG 99% 20ton Hebei Chisure Biotechnology Co., Ltd.
2019-04-24 Diethylenetriaminepentaacetic acid
US $10.00 / kg 1kg 99% 10 MT Hebei Guanlang Biotechnology Co., Ltd.

Diethylenetriaminepentaacetic acid Spectrum

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