Diethylenetriaminepentaacetic acid
- CAS No.
- 67-43-6
- Chemical Name:
- Diethylenetriaminepentaacetic acid
- Synonyms
- DIPA;DTPA;PENTETIC ACID;DETP;DETPA;DETAPAC;DTRA;Detarex;CCDC85B;Chel 330
- CBNumber:
- CB5303977
- Molecular Formula:
- C14H23N3O10
- Molecular Weight:
- 393.35
- MDL Number:
- MFCD00004289
- MOL File:
- 67-43-6.mol
- MSDS File:
- SDS
| Melting point | 219-220 °C (lit.) |
|---|---|
| Boiling point | 517.84°C (rough estimate) |
| Density | 1.56 |
| refractive index | 1.5700 (estimate) |
| Flash point | 200 °C |
| storage temp. | room temp |
| solubility | 0.1 M NaOH: 0.1 M at 20 °C, clear, colorless |
| pka | pK1:;pK2:2.55(+1);pK3:4.33(+2);pK4:8.60(-3);pK5,10.58 (25°C) |
| form | Crystalline Powder |
| color | White to almost white |
| PH | 2-3 (H2O, 20℃)(saturated solution) |
| Water Solubility | 5 g/L (20 ºC) |
| Merck | 14,7125 |
| BRN | 1810219 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | QPCDCPDFJACHGM-UHFFFAOYSA-N |
| LogP | -1.361 (est) |
| CAS DataBase Reference | 67-43-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 7A314HQM0I |
| NIST Chemistry Reference | N,N-Bis(2-(bis-(carboxymethyl)amino)ethyl)-glycine(67-43-6) |
| EPA Substance Registry System | Pentetic acid (67-43-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H332-H361fd-H373 | |||||||||
| Precautionary statements | P201-P202-P260-P304+P340+P312-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xi,N,Xn | |||||||||
| Risk Statements | 36-51/53-36/37/38-20-63 | |||||||||
| Safety Statements | 26-36-61-37/39-36/37 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | MB8205000 | |||||||||
| F | 3 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29224995 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 2000 mg/kg | |||||||||
| NFPA 704 |
|
Diethylenetriaminepentaacetic acid price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2645 | Pentetic Acid Pharmaceutical Secondary Standard; Certified Reference Material | 67-43-6 | 200MG | $186 | 2024-03-01 | Buy |
| Sigma-Aldrich | 32319 | Diethylenetriaminepentaacetic acid for complexometry, ≥99.0% | 67-43-6 | 100g | $84.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 32319 | Diethylenetriaminepentaacetic acid for complexometry, ≥99.0% | 67-43-6 | 500g | $353 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1505506 | Pentetic acid United States Pharmacopeia (USP) Reference Standard | 67-43-6 | 100mg | $436 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1.08426 | Titriplex® V for analysis (diethylenetriaminepentaacetic acid) | 67-43-6 | 100g | $138 | 2024-03-01 | Buy |
Diethylenetriaminepentaacetic acid Chemical Properties,Uses,Production
Chemical Properties
Pentetic acid occurs as a white crystalline solid and is almost odorless.
Chemical Properties
Diethylenetriaminepentaacetic acid is a solid.
Uses
chelating agent, diagnostic aid
Uses
Diethylenetriaminepentaacetic acid is used as chelating agent and forms complexes with metal ions. It finds application as a magnetic resonance imaging (MRI) contrasting agent, since it improves the image by forming a complex with a gadolinium ion. It can also be used for treatment of radioactive materials such as plutonium, americium and other actinides. It is an active component of manganese and zinc fertilizers used in agrochemical industry. It acts as a color inhibitor and is used in the production of acrylon. It is also used in soaps as a water softener.
Uses
Diethylenetriaminepentaacetic Acid is a component of manganese and zinc fertilizers.
Definition
ChEBI: Pentetic acid is a pentacarboxylic acid. It has a role as a copper chelator. It is a conjugate acid of a pentetate(1-).
Production Methods
Pentetic acid is a pentaacetic acid triamine formed during the preparation of the amino carboxylic acid and its salt.
General Description
Visit our Titration Center to learn more.
Pharmaceutical Applications
Pentetic acid is mainly used as a chelating agent in the preparation of imaging and contrast agents for radionuclide and magnetic resonance imaging.It is also used as a carrier excipient for neutron-capture isotopes in, for example, radiotherapy.Pentetic acid–isotope complexes have also been considered as model active substances in scintigraphic imaging studies.Pentetic acid has been used to chelate metal ions to reduce formation of reactive oxygen species during lyophilization.
Safety Profile
Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
Safety
Pentetic acid is used in intrathecal and intravenous injection
preparations. The pure form of pentetic acid is moderately toxic
by the intraperitoneal route.
LD50 (mouse, IP): 0.54 g/kg
LD50 (mouse, oral): 4.84 g/kg
storage
The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.
Purification Methods
Crystallise DTPA from water. Dry under vacuum or at 110o. [Bielski & Thomas J Am Chem Soc 109 7761 1987, NMR: Wenzel et al. Anal Chem 54 615 1982, Beilstein 4 IV 2454.]
Incompatibilities
The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.
Regulatory Status
Included in the FDA Inactive Ingredients Database (intrathecal and intravenous injections). Included in intravenous and intra-articular injections licensed in the UK.
Diethylenetriaminepentaacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| Zjartschem | +86-571-8723 8903 jocelynpan@zjarts.com | jocelynpan@zjarts.com | CHINA | 993 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
View Lastest Price from Diethylenetriaminepentaacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-17 | Diethylenetriaminepentaacetic acid
67-43-6
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2024-03-23 | Diethylenetriaminepentaacetic acid
67-43-6
|
US $30.00-20.00 / kg | 1kg | 99% | 30 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2023-08-22 | Diethylenetriaminepentaacetic acid
67-43-6
|
US $25.00 / kg | 1kg | 99% | 100tons | Anhui Ruihan Technology Co., Ltd |
-
- Diethylenetriaminepentaacetic acid
67-43-6
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- Diethylenetriaminepentaacetic acid
67-43-6
- US $30.00-20.00 / kg
- 99%
- Hebei Yanxi Chemical Co., Ltd.
-
- Diethylenetriaminepentaacetic acid
67-43-6
- US $25.00 / kg
- 99%
- Anhui Ruihan Technology Co., Ltd