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Diethylenetriaminepentaacetic acid

Diethylenetriaminepentaacetic acid
Diethylenetriaminepentaacetic acid structure
CAS No.
67-43-6
Chemical Name:
Diethylenetriaminepentaacetic acid
Synonyms
DETP;DTPA;DTRA;DIPA;DETPA;Detarex;CCDC85B;DETAPAC;Chel 330;cheldtpa
CBNumber:
CB5303977
Molecular Formula:
C14H23N3O10
Formula Weight:
393.35
MOL File:
67-43-6.mol

Diethylenetriaminepentaacetic acid Properties

Melting point:
219-220 °C (lit.)
Boiling point:
517.84°C (rough estimate)
Density 
1.56
refractive index 
1.5700 (estimate)
Flash point:
200 °C
storage temp. 
room temp
solubility 
0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
pka
pK1:;pK2:2.55(+1);pK3:4.33(+2);pK4:8.60(-3);pK5,10.58 (25°C)
form 
Crystalline Powder
color 
White to almost white
PH
2-3 (H2O, 20℃)(saturated solution)
Water Solubility 
5 g/L (20 ºC)
Merck 
14,7125
BRN 
1810219
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
QPCDCPDFJACHGM-UHFFFAOYSA-N
CAS DataBase Reference
67-43-6(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
7A314HQM0I
NIST Chemistry Reference
N,N-Bis(2-(bis-(carboxymethyl)amino)ethyl)-glycine(67-43-6)
EPA Substance Registry System
Pentetic acid (67-43-6)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08,GHS09
Signal word  Warning
Hazard statements  H315-H411-H335-H319-H332-H361d-H373
Precautionary statements  P264-P273-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P391-P501-P260-P280-P305+P351+P338-P261-P280a-P304+P340-P405-P501a
Hazard Codes  Xi,N,Xn
Risk Statements  36-51/53-36/37/38-20-63
Safety Statements  26-36-61-37/39-36/37
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  MB8205000
3
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29224995
Toxicity LD50 orally in Rabbit: > 2000 mg/kg

Diethylenetriaminepentaacetic acid price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 32319 Diethylenetriaminepentaacetic acid for complexometry, ≥99.0% 67-43-6 100g-f $61.1 2020-08-18 Buy
Sigma-Aldrich 32319 Diethylenetriaminepentaacetic acid for complexometry, ≥99.0% 67-43-6 100 g $63 2021-03-22 Buy
Sigma-Aldrich PHR2645 Pentetic Acid Pharmaceutical Secondary Standard; Certified Reference Material 67-43-6 200MG $139 2021-03-22 Buy
Sigma-Aldrich 1.08426 Titriplex® V for analysis (diethylenetriaminepentaacetic acid) 67-43-6 100 g $214.6 2021-03-22 Buy
Sigma-Aldrich 32319 Diethylenetriaminepentaacetic acid for complexometry, ≥99.0% 67-43-6 500 g $262 2021-03-22 Buy

Diethylenetriaminepentaacetic acid Chemical Properties,Uses,Production

Chemical Properties

solid

Chemical Properties

Pentetic acid occurs as a white crystalline solid and is almost odorless.

Chemical Properties

Diethylenetriaminepentaacetic acid is a solid.

Uses

chelating agent, diagnostic aid

Uses

Diethylenetriaminepentaacetic Acid is a component of manganese and zinc fertilizers.

Production Methods

Pentetic acid is a pentaacetic acid triamine formed during the preparation of the amino carboxylic acid and its salt.

Pharmaceutical Applications

Pentetic acid is mainly used as a chelating agent in the preparation of imaging and contrast agents for radionuclide and magnetic resonance imaging.It is also used as a carrier excipient for neutron-capture isotopes in, for example, radiotherapy.Pentetic acid–isotope complexes have also been considered as model active substances in scintigraphic imaging studies.Pentetic acid has been used to chelate metal ions to reduce formation of reactive oxygen species during lyophilization.

Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.

Safety

Pentetic acid is used in intrathecal and intravenous injection preparations. The pure form of pentetic acid is moderately toxic by the intraperitoneal route.
LD50 (mouse, IP): 0.54 g/kg
LD50 (mouse, oral): 4.84 g/kg

storage

The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.

Purification Methods

Crystallise DTPA from water. Dry under vacuum or at 110o. [Bielski & Thomas J Am Chem Soc 109 7761 1987, NMR: Wenzel et al. Anal Chem 54 615 1982, Beilstein 4 IV 2454.]

Incompatibilities

The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.

Regulatory Status

Included in the FDA Inactive Ingredients Database (intrathecal and intravenous injections). Included in intravenous and intra-articular injections licensed in the UK.

Diethylenetriaminepentaacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products


Diethylenetriaminepentaacetic acid Suppliers

Global( 334)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20918 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Zjartschem
+86-571-8723 8903 jocelynpan@zjarts.com
+86-571-87063838 jocelynpan@zjarts.com CHINA 997 58
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1009 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5882 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4000 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58

View Lastest Price from Diethylenetriaminepentaacetic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-25 Diethylenetriaminepentaacetic acid
67-43-6
US $20.00 / Kg/Drum 25Kg/Drum 99.99% 1 ton per week Wuhan Mulei New Material Technology Co. Ltd
2021-09-29 Diethylenetriaminepentaacetic acid
67-43-6
US $1.00 / KG 1KG 99.0%-100.00% 10ton/month WUHAN FORTUNA CHEMICAL CO., LTD
2021-08-14 Diethylenetriaminepentaacetic acid USP/EP/BP
67-43-6
US $1.10 / g 1g 0.999 100 Tons min Dideu Industries Group Limited

Diethylenetriaminepentaacetic acid Spectrum


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