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Diethylenetriaminepentaacetic acid

Diethylenetriaminepentaacetic acid
Diethylenetriaminepentaacetic acid structure
CAS No.
67-43-6
Chemical Name:
Diethylenetriaminepentaacetic acid
Synonyms
DETP;DTPA;DTRA;DIPA;DETPA;Detarex;CCDC85B;DETAPAC;Chel 330;cheldtpa
CBNumber:
CB5303977
Molecular Formula:
C14H23N3O10
Formula Weight:
393.35
MOL File:
67-43-6.mol

Diethylenetriaminepentaacetic acid Properties

Melting point:
219-220 °C(lit.)
Boiling point:
517.84°C (rough estimate)
Density 
1.56
refractive index 
1.5700 (estimate)
Flash point:
200 °C
storage temp. 
-20°C
solubility 
0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
pka
pK1:;pK2:2.55(+1);pK3:4.33(+2);pK4:8.60(-3);pK5,10.58 (25°C)
form 
Crystalline Powder
color 
White to almost white
PH
2-3 (H2O, 20℃)(saturated solution)
Water Solubility 
5 g/L (20 ºC)
Merck 
14,7125
BRN 
1810219
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
QPCDCPDFJACHGM-UHFFFAOYSA-N
CAS DataBase Reference
67-43-6(CAS DataBase Reference)
NIST Chemistry Reference
N,N-Bis(2-(bis-(carboxymethyl)amino)ethyl)-glycine(67-43-6)
EPA Substance Registry System
Glycine, N,N-bis[2-[bis(carboxymethyl) amino]ethyl]-(67-43-6)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,N,Xn
Risk Statements  36-51/53-36/37/38-20-63
Safety Statements  26-36-61-37/39-36/37
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  MB8205000
3
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29224995
Toxicity LD50 orally in Rabbit: > 2000 mg/kg
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P391 Collect spillage. Hazardous to the aquatic environment
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P501 Dispose of contents/container to..…

Diethylenetriaminepentaacetic acid price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 32319 Diethylenetriaminepentaacetic acid for complexometry, ≥99.0% 67-43-6 100g-f $57.7 2018-11-20 Buy
Sigma-Aldrich 1505506 Pentetic acid United States Pharmacopeia (USP) Reference Standard 67-43-6 100mg $348 2018-11-13 Buy
TCI Chemical D0504 Diethylenetriaminepentaacetic Acid >98.0%(T) 67-43-6 25g $17 2018-11-22 Buy
TCI Chemical D0504 Diethylenetriaminepentaacetic Acid >98.0%(T) 67-43-6 500g $57 2018-11-22 Buy
Alfa Aesar A10926 Diethylenetriaminepentaacetic acid, 98+% 67-43-6 250g $35.3 2018-11-13 Buy

Diethylenetriaminepentaacetic acid Chemical Properties,Uses,Production

Chemical Properties

solid

Chemical Properties

Pentetic acid occurs as a white crystalline solid and is almost odorless.

Uses

chelating agent, diagnostic aid

Uses

Diethylenetriaminepentaacetic Acid is a component of manganese and zinc fertilizers.

Production Methods

Pentetic acid is a pentaacetic acid triamine formed during the preparation of the amino carboxylic acid and its salt.

Pharmaceutical Applications

Pentetic acid is mainly used as a chelating agent in the preparation of imaging and contrast agents for radionuclide and magnetic resonance imaging.It is also used as a carrier excipient for neutron-capture isotopes in, for example, radiotherapy.Pentetic acid–isotope complexes have also been considered as model active substances in scintigraphic imaging studies.Pentetic acid has been used to chelate metal ions to reduce formation of reactive oxygen species during lyophilization.

Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.

Safety

Pentetic acid is used in intrathecal and intravenous injection preparations. The pure form of pentetic acid is moderately toxic by the intraperitoneal route.
LD50 (mouse, IP): 0.54 g/kg
LD50 (mouse, oral): 4.84 g/kg

storage

The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.

Purification Methods

Crystallise DTPA from water. Dry under vacuum or at 110o. [Bielski & Thomas J Am Chem Soc 109 7761 1987, NMR: Wenzel et al. Anal Chem 54 615 1982, Beilstein 4 IV 2454.]

Incompatibilities

The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.

Regulatory Status

Included in the FDA Inactive Ingredients Database (intrathecal and intravenous injections). Included in intravenous and intra-articular injections licensed in the UK.

Diethylenetriaminepentaacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products


Diethylenetriaminepentaacetic acid Suppliers

Global( 238)Suppliers
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Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21967 58
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0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
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career henan chemical co
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View Lastest Price from Diethylenetriaminepentaacetic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-23 Diethylenetriaminepentaacetic acid
67-43-6
US $2.00 / kg 1kg 9% 100kg career henan chemical co
2018-11-06 best price white powder Diethylenetriaminepentaacetic acid
67-43-6
US $1.00 / KG 1KG 99% 20ton Hebei Chisure Biotechnology Co., Ltd.
2019-04-24 Diethylenetriaminepentaacetic acid
67-43-6
US $10.00 / kg 1kg 99% 10 MT Hebei Guanlang Biotechnology Co., Ltd.

Diethylenetriaminepentaacetic acid Spectrum


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