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AZD 3759

Selective EGFR inhibitor
AZD 3759
AZD 3759 structure
CAS No.
1626387-80-1
Chemical Name:
AZD 3759
Synonyms
azd3579;AZD3759;CS-1596;AZD-3759;AZD 3759;HY-18750;AZD37591;zorifertinib.;zorifertinibum;AZD3759 Powder
CBNumber:
CB53041786
Molecular Formula:
C22H23ClFN5O3
Formula Weight:
459.9
MOL File:
1626387-80-1.mol

AZD 3759 Properties

Boiling point:
571.4±50.0 °C(Predicted)
Density 
1.358±0.06 g/cm3(Predicted)
pka
6.71±0.40(Predicted)

AZD 3759 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19931 AZD 3759 ≥98% 1626387-80-1 1mg $25 2021-03-22 Buy
Cayman Chemical 19931 AZD 3759 ≥98% 1626387-80-1 5mg $81 2021-03-22 Buy
Cayman Chemical 19931 AZD 3759 ≥98% 1626387-80-1 10mg $150 2021-03-22 Buy
Cayman Chemical 19931 AZD 3759 ≥98% 1626387-80-1 25mg $281 2021-03-22 Buy

AZD 3759 Chemical Properties,Uses,Production

Selective EGFR inhibitor

AZD3759 is a selective EGFR inhibitor that can fully penetrate the blood-brain barrier (BBB), with equal free concentrations in the blood, cerebrospinal fluid, and brain tissue. Treatment with AZD3759 causes tumor regression in subcutaneous xenograft, leptomeningeal metastasis (LM), and brain metastasis (BM) lung cancer models and prevents the development of BM in nude mice.

Description

AZD3759 is an EGFP inhibitor (Epidermal growth factor receptor tyrosine kinase inhibitor) with blood brain barrier (BBB) penetration. It has the potential for the treatment of non-small cell lung cancer (NSCLC), with brain metastases (BM) and leptomengingeal metastases (LM) since this type of cancer often contain a lot of activating mutations of the epidermal growth factor receptor (EGFR). It has excellent capability of penetrating the blood brain barrier to reach the central nervous system. 

References

Zeng, Qingbei, et al. "Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI)." Journal of Medicinal Chemistry 58.20(2015):8200.
Yang, Zhenfan, et al. "Abstract LB-217: Antitumor activities of AZD3759, a novel EGFR inhibitor with excellent penetration across central nervous system (CNS), in preclinical animal models." Cancer Research 76.14 Supplement(2016):LB-217-LB-217.
Xiong, S., et al. "Determination of AZD3759 in rat plasma and brain tissue by LC-MS/MS and its application in pharmacokinetic and brain distribution studies." Journal of Pharmaceutical & Biomedical Analysis140(2017):362-366.

AZD 3759 Preparation Products And Raw materials

Raw materials

Preparation Products


AZD 3759 Suppliers

Global( 215)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951
025-84209270 wgp@nanjing-pharmaceutical.com CHINA 115 55
Jurong Coupling Biotechnology Co., Ltd.
13656108824
coupling278191416@hotmail.com CHINA 184 58
Shanghai Payne Pharmaceutical Technology Co.Ltd
18678586262 021-58123769
info@paynepharm.com China 1355 58
Handan Tongyi New Material Technology Co., Ltd
+8617330042575
ty003@handantongyi.com CHINA 339 58
Hebei Yirun Sega Biological Technology Co. Ltd
19932103556 +8619932103556
+8619932103556 linda@yrsjbiotech.com CHINA 1426 58
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58
Shijiazhuang Tongyang Import and Export Co., LTD

admin@sjztongyang.com CHINA 995 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20911 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55

Related articles


View Lastest Price from AZD 3759 manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-03 AZD 3759
1626387-80-1
US $100.00 / ASSAYS 1ASSAYS 99.9% 800kgs/month Handan Tongyi New Material Technology Co., Ltd
2021-11-15 AZD3759
1626387-80-1
US $0.00 / KG 1KG 99% 200000pcs Hebei Yirun Sega Biological Technology Co. Ltd
2021-11-15 Anti Cancer Azd3759, High Purity
1626387-80-1
US $0.00-0.00 / g 1KG 96% 1000/Ton/Month Hebei Yirun Sega Biological Technology Co. Ltd

1626387-80-1(AZD 3759)Related Search:


  • AZD 3759
  • AZD3759
  • AZD-3759
  • (2R)-2,4-Dimethyl-1-piperazinecarboxylic acid 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester
  • HY-18750
  • azd3579
  • 1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-
  • 1-PIPERAZINECARBOXYLIC ACID, 2,4-DIMETHYL-, 4-[(3-CHLORO-2-FLUOROPHENYL)AMINO]-7-METHOXY-6-QUINAZOLINYL ESTER
  • 4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (2R)-2,4-dimethylpiperazine-1-carb
  • (R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate
  • zorifertinibum
  • AZD3759; AZD-3759; AZD 3759; ZORIFERTINIBUM; ZORIFERTINIB.
  • zorifertinib.
  • 4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl 1-piperazinecarboxylic acid 2,4-dimethyl ester
  • 4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (2R)-2,4-dimethylpiperazine-1-carboxylate
  • CS-1596
  • AZD-3759;AZD 3759;;AZD3759
  • AZD37591
  • 4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (R)-2,4-dimethylpiperazine-1-carboxylate
  • High Purity Azd 3759 CAS:
  • High Purity Azd3759/Azd-3759 CAS 1626387-80-1 with Steady Supply
  • Anti Cancer Azd3759, High Purity
  • AZD3759 Powder
  • 1626387-80-1
  • 626387-80-1
  • C22H23ClFN5O3
  • API
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