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Tosylmethyl isocyanide

Chemical Name:
Tosylmethyl isocyanide
Molecular Formula:
Molecular Weight:
MOL File:
MSDS File:

Tosylmethyl isocyanide Properties

Melting point 109-113 °C(lit.)
Density 1.2721 (rough estimate)
refractive index 1.5270 (estimate)
storage temp. 2-8°C
solubility water: slightly soluble
form Liquid
color Clear
Water Solubility insoluble
Sensitive Moisture Sensitive
Merck 14,9556
BRN 3592382
CAS DataBase Reference 36635-61-7(CAS DataBase Reference)


Risk and Safety Statements

Signal word  Danger
Hazard statements  H300-H311-H331-H301+H311+H331
Precautionary statements  P280h-P309-P310-P261-P280-P301+P310-P311
Hazard Codes  T,Xi
Risk Statements  23/24/25
Safety Statements  36/37-45-38-36/37/39-28A
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
Hazard Note  Irritant
HazardClass  6.1(b)
PackingGroup  III
HS Code  29299000

Tosylmethyl isocyanide price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 188204 p-Toluenesulfonylmethyl isocyanide 98% 36635-61-7 5g $35.3 2022-05-15 Buy
Sigma-Aldrich 188204 p-Toluenesulfonylmethyl isocyanide 98% 36635-61-7 25g $145 2022-05-15 Buy
TCI Chemical T1046 p-Toluenesulfonylmethyl Isocyanide >98.0%(HPLC)(N) 36635-61-7 5g $33 2022-04-27 Buy
TCI Chemical T1046 p-Toluenesulfonylmethyl Isocyanide >98.0%(HPLC)(N) 36635-61-7 25g $105 2022-04-27 Buy
Alfa Aesar A14312 p-Toluenesulfonylmethyl isocyanide, 97% 36635-61-7 25g $123 2021-12-16 Buy
Product number Packaging Price Buy
188204 5g $35.3 Buy
188204 25g $145 Buy
T1046 5g $33 Buy
T1046 25g $105 Buy
A14312 25g $123 Buy

Tosylmethyl isocyanide Chemical Properties,Uses,Production

Chemical Properties

Pale yellow to light brown crystalline powder


Tosylmethyl Isocyanide is used as a synthetic reagent in the preparation of variety or biologically active heterocycles such as pyrroles and imidazoles. Tosylmethyl Isocyanide is reported to inhibit [ Fe]-hydrogenase with very high affinity.


Versatile synthon in organic chemistry, especially in the synthesis of heterocyclic Compounds.


Reagent for use in the preparation of biologically active pyrroles and imidazoles.1,2


N-(p-Tolylsulfonylmethyl)formamide 1609:

A 3-L, three-necked, round-bottomed flask, equipped with a mechanical stirrer, a condenser, and a thermometer, was charged with sodium p-toluenesulfinate 1606 (267 g, 1.5 mol). After the addition of water (750 mL), a 34–37% solution of formaldehyde 1607 (350 mL, 378 g, ca. 4.4 mol), formamide 1608 (600 mL, 680 g, 15 mol), and formic acid (200 mL, 244 g, 5.3 mol), the stirred reaction mixture was heated at 90 C°. The sodium p-toluenesulfinate dissolved during the heating, and the clear solution was kept at 90–95 C° for 2 h. It was then cooled in an ice/salt bath with continued stirring and further cooled overnight in a freezer at 20 C°. The white solid produced was collected by suction filtration. It was washed thoroughly in a beaker by stirring with three 250 mL portions of iced water. The product was dried under reduced pressure over phosphorus pentoxide at 70 C° to provide 134–150 g (42–47%) of crude N-(p-tolylsulfonylmethyl)formamide 1609; mp 106–110 C°. This product was sufficiently pure to be used directly in the following reaction.

Purification Methods

Use an efficient fume cupboard. Purify TOSMIC by dissolving (50g) in CH2Cl2 (150mL) and passing it through a column (40x3cm) containing neutral alumina (100g) in CH2Cl2 and eluting with CH2Cl2. A nearly colourless solution (700mL) is collected, evaporated in vacuo and the residue (42-47g) of TOSMIC (m 113-114o dec) is recrystallised once from MeOH (m 116-117o dec). [Hoogenboom et al. Org Synth 57 102 1977, Lensen Tetrahedron Lett 2367 1972.] It also crystallises from EtOH (charcoal) [Saito & Itano, J Chem Soc, Perkin Trans 1 1 1986].

Tosylmethyl isocyanide Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 412)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 China 19994 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 16666 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 China 22021 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 China 9382 55
career henan chemical co
+86-0371-86658258 China 29959 58
Jinan Carbotang Biotech Co.,Ltd.
+8615866703830 China 3639 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 +86-19930503282 China 5953 58
Hubei xin bonus chemical co. LTD
86-13657291602 CHINA 23035 58
Shandong chuangyingchemical Co., Ltd.
18853181302 CHINA 5917 58
Chengdu Feibo Pharm Technology Co., Ltd
15982321820 CHINA 3281 58

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View Lastest Price from Tosylmethyl isocyanide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-14 Tosmic Tosylmethyl Isocyanide
US $100000.00 / Kg/Bag 25KG 99.99% 200ton Hebei Mojin Biotechnology Co., Ltd
2021-10-09 Tosylmethyl isocyanide
US $0.00 / Kg/Bag 1Kg/Bag 99% 20ton Hebei Mojin Biotechnology Co., Ltd
2021-07-13 Tosylmethyl isocyanide
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
1-[(isocyanomethyl)sulfonyl]-4-methyl-benzen Tosylmethyl isocyani Isocyanomethyl 4-methylphenyl sulphone 4-[(Isocyanomethyl)sulphonyl]toluene, (Toluene-4-sulphonyl)methyl isocyanide (p-Toluensulfonyl)methylisocyanide (p-Tolylsulfonyl)methyl isocyanide, TosMIC, Tosylmethyl isocyanide (4-Methylphenylsulfonylmethyl) isocyanide 4-Methylphenylsulfonylmethyl isocyanide Tosylmethyl isocyanide,98% p-Toluenesulfonyl Isocyanide P-tolysulfonylmethylisocyanide TosylMethyl isocyanide, 98% 25GR TosylMethyl isocyanide, 98% 5GR 4-TolylsulfonylMethyl Isocyanide IsocyanoMethyl p-Tolyl Sulfone TosMIC Tosylmethyl Isocyanide p-ToluenesulonylMethy isocyanide 4-[(Isocyanomethyl)sulphonyl]toluene, (Toluene-4-sulphonyl)methyl isocyanide, TosMIC TosylMethyl Isocyanide, TOSMIC 4-TOLUENESULFONYLMETHYL ISOCYANIDE FOR S METHYLIDYNE[[(4-METHYLPHENYL)SULFONYL]METHYL]AMMONIUM LABOTEST-BB LT00159629 BENZENE, 1-[(ISOCYANOMETHYL)SULFONYL]-4-METHYL- 1-[(ISOCYANOMETHYL)SULFONYL]-4-METHYLBENZENE 4-TOLUENSULFONYLMETHYL ISOCYANIDE 4-TOLUENESULPHONYLMETHYL ISOCYANIDE (P-TOLYLSULFONYL)METHYL ISOCYANIDE TOSYLMETHYL ISOCYANIDE TOLUENE-4-SULFONYLMETHYL ISOCYANIDE 4-Toluenesulfonylmethyl isocyanate p-Toluenesulfonylmethyl isocyanide, 98+% p-Toluenesulfonylmethylisocyanide,97+% 1-ISOCYANOMETHANESULFONYL-4-METHYL-BENZENE p-toluenesulfonylmethyl isocyande p-Toluenesulfonylmethyl isocyanate P-TOLUENESULFONYLMETHYL ISOCYANIDE 98% p-ToluenesulfonylMethyl isocyanide, 98.5% p-Toluenesulfonylmethyl Isocyanide 4-Toluenesulfonylmethyl isocyanide for synthesis Tosylmethyleisocyanide 1-[(ISOCYANOMETHYL)SULFONYL]- Tosylmethyl isocyanide, 98%, for synthesis Tosylmethyl isocyanide fandachem Tosylmethyl isocyanide ISO 9001:2015 REACH p-Toluenesulfonyl methylisocyanide (Tosmic, Tosyl methylisocyanide) Tosylmethy isocyanide ,98% Toluenesulfonyl Methyl isocyanide 4-TOLUENESULFONYLMETHYL ISOCYANIDE P-TOLUENESULFONYLMETHYL ISOCYANIDE P-TOLUENESULPHONYLMETHYL ISOCYANIDE TOSMIC isocyanide 36635-61-7 CH3C6H4SO2CH2NC Organic Building Blocks Isocyanides Nitrogen Compounds Sulfur Compounds (for Synthesis)