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GPRP (acetate)

GPRP (acetate) structure

CAS No.: 157009-81-9

Chemical Name:: GPRP (acetate)

Synonyms: Pefa 6003;Pefabloc FG);GPRP (acetate);GPRP ACETATE, >98%;H-Gly-Pro-Arg-Pro-OH (acetate);GLY-PRO-ARG-PRO ACETATE;PEFABLOC FG;GPRP acetate (67869-62-9 free base);GPRP acetate (Gly-Pro-Arg-Pro acetate;L-Proline, glycyl-L-prolyl-L-arginyl-, acetate (1:1);GPRP acetate,Gly-Pro-Arg-Pro acetate,Glycyl-L-prolyl-L-arginyl-L-proline acetate,Pefa 6003,Pefabloc FG, >98%

CBNumber:: CB53121103

Molecular Formula:: C20H35N7O7

Molecular Weight:: 485.54

MDL Number:: MFCD00133378

MOL File:: 157009-81-9.mol

Last updated:2025-07-23 21:37:54

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GPRP (acetate) Properties

solubility	PBS (pH 7.2): 10 mg/ml
form	A crystalline solid
color	White to off-white
Sequence	H-Gly-Pro-Arg-Pro-OH

GPRP (acetate) price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21163	H-Gly-Pro-Arg-Pro-OH (acetate) ≥95%	157009-81-9	1mg	$28	2024-03-01	Buy
Cayman Chemical	21163	H-Gly-Pro-Arg-Pro-OH (acetate) ≥95%	157009-81-9	5mg	$85	2024-03-01	Buy
Cayman Chemical	21163	H-Gly-Pro-Arg-Pro-OH (acetate) ≥95%	157009-81-9	10mg	$117	2024-03-01	Buy
Cayman Chemical	21163	H-Gly-Pro-Arg-Pro-OH (acetate) ≥95%	157009-81-9	25mg	$161	2024-03-01	Buy
Biorbyt Ltd	orb611349	GPRP acetate	157009-81-9	5mg	$615.4	2021-12-16	Buy

Product number	Packaging	Price	Buy
21163	1mg	$28	Buy
21163	5mg	$85	Buy
21163	10mg	$117	Buy
21163	25mg	$161	Buy
orb611349	5mg	$615.4	Buy

GPRP (acetate) Chemical Properties,Uses,Production

Uses

GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa)[1][2][3].

in vivo

GPRP acetate (100 mg/kg; i.p., once daily for 10 days) significantly alleviates DSS-induced colitis through the improvement of body weight loss and mortality^[3].

Animal Model:	C57BL/6 mice with dextran sulphate sodium (DSS)-induced colitis^[3]
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; 100 mg/kg, once daily, for 10 days
Result:	Significantly inhibited body weight loss and reduced DSS-induced mortality and shortening of colon length, and decreased tissue damage and infiltration of inflammatory cells in colitis mice. Decreased levels of inflammatory cytokines in colitis mice.

References

[1] Gallistl S, et al. Gly-pro-arg-pro (GPRP) enhances free thrombin. Thromb Res. 1995 Jun 15;78(6):547-50. DOI:10.1016/0049-3848(95)e0088-8
[2] Hsieh KH, et, al. Fibrin Polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization. J Med Chem. 1981 Mar; 24(3): 322-7. DOI:10.1021/jm00135a016
[3] Zhang C, et al. Fibrinogen/AKT/Microfilament Axis Promotes Colitis by Enhancing Vascular Permeability. Cell Mol Gastroenterol Hepatol. 2021;11(3):683-696. DOI:10.1016/j.jcmgh.2020.10.007

GPRP (acetate) Preparation Products And Raw materials

Raw materials

Preparation Products

GPRP (acetate) Suppliers

Global( 63)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30230	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10473	58
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	sales@dogechemical.com	China	4128	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38838	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Changsha MOL Changes Biotechnology Co., Ltd.	+8619375158599	info@molchanges.com	China	5220	58
DONBOO AMINO ACID COMPANY	+8618051385538	donboo@donboo.com	China	9363	58

Supplier	Advantage
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
Career Henan Chemica Co	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nanjing Doge Biomedical Technology Co., Ltd	58
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Changsha MOL Changes Biotechnology Co., Ltd.	58
DONBOO AMINO ACID COMPANY	58

View Lastest Price from GPRP (acetate) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-07-23	GPRP acetate (67869-62-9 free base) 157009-81-9	US $43.00-137.00 / mg		100.00%	10g	TargetMol Chemicals Inc.

GPRP acetate (67869-62-9 free base)
157009-81-9
US $43.00-137.00 / mg
100.00%
TargetMol Chemicals Inc.

157009-81-9(GPRP (acetate))Related Search:

FIBRINOGEN GAMMA-CHAIN (117-133) FIBRINOGEN GAMMA-CHAIN (397-411) FIBRONECTIN CS-1 FRAGMENT (1978-1985) HIS-HIS-LEU-GLY-GLY-ALA-LYS-GLN-ALA-GLY-ASP-VAL FIBRINOPEPTIDE B

GPRP (acetate) H-Gly-Pro-Arg-Pro-OH (acetate) Pefa 6003 GLY-PRO-ARG-PRO ACETATE;PEFABLOC FG GPRP acetate,Gly-Pro-Arg-Pro acetate,Glycyl-L-prolyl-L-arginyl-L-proline acetate,Pefa 6003,Pefabloc FG, >98% GPRP ACETATE, >98% Pefabloc FG) GPRP acetate (Gly-Pro-Arg-Pro acetate GPRP acetate (67869-62-9 free base) L-Proline, glycyl-L-prolyl-L-arginyl-, acetate (1:1) fibrinogen,GPRP acetate (67869 62 9 free base),Fibrin,inhibit,polymerization,GPRP,Pefa6003,IIb/IIIa,Pefa-6003,GPIIb/IIIa,glycoprotein,Inhibitor,platelet,GPRP acetate (67869629 free base) (S)-1-((S)-2-((S)-1-(2-aminoacetyl)pyrrolidine-2-carboxamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxylic acid compound with acetic acid (1:1) (S)-1-((S)-2-((S)-1-(2-Aminoacetyl)pyrrolidine-2-carboxamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxylic acid acetate 157009-81-9