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TA-01

TA-01 structure

CAS No.: 1784751-18-3

Chemical Name:: TA-01

Synonyms: TA-01;TA-01;TA01;TA 01;TA 01,Inhibitor,Casein Kinase,Autophagy,p38 MAPK,inhibit,TA01,TA-01;4-(2-(2,6-Difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyridine;Pyridine, 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-

CBNumber:: CB53122933

Molecular Formula:: C20H12F3N3

Molecular Weight:: 351.32

MDL Number:: MFCD30182287

MOL File:: 1784751-18-3.mol

Last updated:2023-09-04 15:51:00

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TA-01 Properties

Boiling point	511.1±50.0 °C(Predicted)
Density	1.337±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml; DMSO: 3 mg/ml
form	A crystalline solid
pka	9.26±0.24(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

TA-01 price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	24667	TA-01 ≥98%	1784751-18-3	1mg	$32	2024-03-01	Buy
Cayman Chemical	24667	TA-01 ≥98%	1784751-18-3	5mg	$145	2024-03-01	Buy
Cayman Chemical	24667	TA-01 ≥98%	1784751-18-3	10mg	$275	2024-03-01	Buy
Cayman Chemical	24667	TA-01 ≥98%	1784751-18-3	25mg	$571	2024-03-01	Buy
TRC	T779005	TA01	1784751-18-3	50mg	$875	2021-12-16	Buy

Product number	Packaging	Price	Buy
24667	1mg	$32	Buy
24667	5mg	$145	Buy
24667	10mg	$275	Buy
24667	25mg	$571	Buy
T779005	50mg	$875	Buy

TA-01 Chemical Properties,Uses,Production

Description

TA-01 is a derivative of the p38 MAPK inhibitor SB 203580 (Item Nos. 13067 | 13344) and an inducer of cardiomyocyte differentiation. It is cardiomyogenic at concentrations less than 5 μM, increasing expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreasing expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5^eGFP/w cells when applied after embryoid body formation. TA-01 inhibits casein kinase 1ε (CK1ε) and CK1Δ and reduces expression of Wnt/β-catenin signaling pathway members, activities that positively correlate with its cardiomyogenic activity.

Uses

TA 01 induces cardiomyocyte differentiation of pluripotent stem cells.

TA-01 Preparation Products And Raw materials

Raw materials

Preparation Products

TA-01 Suppliers

Global( 54)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
Shanghaizehan biopharma technology co., Ltd.	021-61350663 13052117465	sales@zehanbiopharma.com	China	990	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Boyle Chemical Co., Ltd.	55
Shanghaizehan biopharma technology co., Ltd.	55

TA-01 Spectrum

TA-01(1784751-18-3)¹HNMR

1784751-18-3(TA-01)Related Search:

TA-02

TA-01 TA-01;TA01;TA 01 Pyridine, 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]- 4-(2-(2,6-Difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyridine TA 01,Inhibitor,Casein Kinase,Autophagy,p38 MAPK,inhibit,TA01,TA-01 1784751-18-3 C20H12F3N3