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ChemicalBook >> CAS DataBase List >>7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide Structure
7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide structure
CAS No.
1633350-06-7
Chemical Name:
7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
Synonyms
BGB-3111;EOS-61237;(±)-BGB3111);(±)-BGB 3111;BGB3111; BGB 3111;Zanubrutinib Racemate;(±)-Zanubrutinib ((±)-BGB-3111;(±)-Zanubrutinib, 10 mM in DMSO;(±)Zanubrutinib,(±) Zanubrutinib;7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CBNumber:
CB53142878
Molecular Formula:
C27H29N5O3
Molecular Weight:
471.55
MDL Number:
MFCD30738015
MOL File:
1633350-06-7.mol
Last updated:2025-11-10 14:44:25
Product description Number Pack Size Price
(±)-Zanubrutinib 99.70% CS-6366 5mg $140
(±)-Zanubrutinib 99.70% CS-6366 10mg $220
(±)-Zanubrutinib 99.70% CS-6366 50mg $880
BGB-3111 >98% DC10335 100mg $900
BGB-3111 >98% DC10335 250mg $1800
Request For Quotation

7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide Properties

Boiling point 713.4±60.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 30 mg/mL (63.62 mM);Ethanol : ≥ 10 mg/mL (21.21 mM)
form Solid
pka 15.35±0.40(Predicted)
color White to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501

7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-6366 (±)-Zanubrutinib 99.70% 1633350-06-7 5mg $140 2021-12-16 Buy
ChemScene CS-6366 (±)-Zanubrutinib 99.70% 1633350-06-7 10mg $220 2021-12-16 Buy
ChemScene CS-6366 (±)-Zanubrutinib 99.70% 1633350-06-7 50mg $880 2021-12-16 Buy
DC Chemicals DC10335 BGB-3111 >98% 1633350-06-7 100mg $900 2021-12-16 Buy
DC Chemicals DC10335 BGB-3111 >98% 1633350-06-7 250mg $1800 2021-12-16 Buy
Product number Packaging Price Buy
CS-6366 5mg $140 Buy
CS-6366 10mg $220 Buy
CS-6366 50mg $880 Buy
DC10335 100mg $900 Buy
DC10335 250mg $1800 Buy

7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide Chemical Properties,Uses,Production

Uses

(±)-Zanubrutinib ((±)-BGB-3111) is the racemate of Zanubrutinib (HY-101474A). (±)-Zanubrutinib inhibits Bruton's tyrosine kinase (Btk) with an IC50 of 0.63 nM[1].

in vivo

(±)-Zanubrutinib induces dose-dependent anti-tumor effects against REC-1 MCL xenografts engrafted either subcutaneously or systemically via tail vein injection in mice. In the subcutaneous xenografts. Preliminary 14-day toxicity study in rats shows that (±)-Zanubrutinib is very well tolerated and maximal tolerate dose (MTD) is not reached when it is dosed up to 250mg/kg/day[1].

References

[1] Na L, et al. BGB-3111 is a novel and highly selective Bruton's tyrosine kinase (BTK) inhibitor. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2597. doi:10.1158/1538-7445.AM2015-2597

7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide Suppliers

Global( 45)Suppliers
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Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30229 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39035 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500 nickzhang@hangyubiotech.com China 10997 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39002 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7778 56
Shanghai Changyan Chem & Tech Co., Ltd. 021-20242659 18930833303 Sales@changyanchem.cn China 5009 55
Jinan elephant international trading co., LTD 13006575422@163.com China 6355 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720 psaitong@jm-bio.com China 12306 58
Supplier Advantage
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Shanghai Changyan Chem & Tech Co., Ltd. 55
Jinan elephant international trading co., LTD 58
Beijing Jin Ming Biotechnology Co., Ltd. 58

View Lastest Price from 7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(±)-Zanubrutinib pictures 2025-11-10 (±)-Zanubrutinib
1633350-06-7
 US $42.00-156.00 / mg 99.09% 10g TargetMol Chemicals Inc.

7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide Spectrum

7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide(1633350-06-7)1HNMR

1633350-06-7(7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide)Related Search:

Ceritinib (LDK378) Ibrutinib
7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide BGB-3111 BGB3111; BGB 3111 EOS-61237 Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)- Zanubrutinib Racemate (±)Zanubrutinib,(±) Zanubrutinib (±)-Zanubrutinib, 10 mM in DMSO (±)-BGB 3111 (±)-BGB3111) (±)-Zanubrutinib ((±)-BGB-3111 1633350-06-7