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17β-hydroxy Wortmannin

17β-hydroxy Wortmannin Structure
17β-hydroxy Wortmannin structure
CAS No.
58053-83-1
Chemical Name:
17β-hydroxy Wortmannin
Synonyms
17β-hydroxy Wortmannin;17.beta.-hydroxy Wortmannin;XLJORQYAOTYVQS-OGCOKEDGSA-N;17β-hydroxy Wortmannin Exclusive;17β-hydroxy Wortmannin Exclusive;PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem;3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6(1H)-dione, 11-(acetyloxy)-6b,7,8,9,9a,10,11,11b-octahydro-9-hydroxy-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9S,9aS,11R,11bR)-
CBNumber:
CB53152437
Molecular Formula:
C23H26O8
Molecular Weight:
430.45
MDL Number:
MFCD00939536
MOL File:
58053-83-1.mol
Last updated:2023-06-08 09:03:09
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17β-hydroxy Wortmannin Properties

Boiling point 615.4±55.0 °C(Predicted)
Density 1.39±0.1 g/cm3(Predicted)
storage temp. +2C to +8C
solubility DMF: 3 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 0.15 mg/ml
form Off-white solid
pka 14.49±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300+H310+H330
Precautionary statements  P260-P262-P264-P270-P271-P280-P284-P301+P310-P330-P302+P352-P304+P340-P320-P361+P364-P403+P233-P405-P501
NFPA 704
0
4 0

17β-hydroxy Wortmannin price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 528119 PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem 58053-83-1 5mg $294 2023-01-07 Buy
Cayman Chemical 13812 17β-hydroxy Wortmannin ≥98% 58053-83-1 500μg $59 2024-03-01 Buy
Cayman Chemical 13812 17β-hydroxy Wortmannin ≥98% 58053-83-1 1mg $108 2024-03-01 Buy
Cayman Chemical 13812 17β-hydroxy Wortmannin ≥98% 58053-83-1 5mg $448 2024-03-01 Buy
Cayman Chemical 13812 17β-hydroxy Wortmannin ≥98% 58053-83-1 10mg $783 2024-03-01 Buy
Product number Packaging Price Buy
528119 5mg $294 Buy
13812 500μg $59 Buy
13812 1mg $108 Buy
13812 5mg $448 Buy
13812 10mg $783 Buy

17β-hydroxy Wortmannin Chemical Properties,Uses,Production

Description

17β-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM). 17β-hydroxy Wortmannin inhibits recombinant PI3K and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC50 = 1.46 μM). The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin.

17β-hydroxy Wortmannin Preparation Products And Raw materials

Raw materials

Preparation Products

WORTMANNIN

17β-hydroxy Wortmannin Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
BOC Sciences 65
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
17β-hydroxy Wortmannin Exclusive XLJORQYAOTYVQS-OGCOKEDGSA-N 17.beta.-hydroxy Wortmannin PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem 3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6(1H)-dione, 11-(acetyloxy)-6b,7,8,9,9a,10,11,11b-octahydro-9-hydroxy-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9S,9aS,11R,11bR)- 17β-hydroxy Wortmannin 17β-hydroxy Wortmannin Exclusive 58053-83-1