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Dolutegravir Impurity 3
- CAS No.
- 1973402-05-9
- Chemical Name:
- Dolutegravir Impurity 3
- Synonyms
- Dotiravir Impurity 3;Dolutegravir Impurity 3;Dolutegravir impurity A;Dolutegravir Impurity 51;DolutegravirImpurity9SodiumSalt;(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]p;(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide;N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide;2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-;Dolutegravir impurity 2/2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
- CBNumber:
- CB53154305
- Molecular Formula:
- C20H19F2N3O5
- Molecular Weight:
- 419.38
- MDL Number:
- MOL File:
- 1973402-05-9.mol
Last updated:2023-07-14 17:30:25
| Melting point | 95-100°C |
|---|---|
| Boiling point | 662.3±55.0 °C(Predicted) |
| Density | 1.51±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.50±1.00(Predicted) |
| color | Yellow |
| FDA UNII | XM665LD5AD |
Dolutegravir Impurity 3 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D447205 | N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide | 1973402-05-9 | 2.5mg | $215 | 2021-12-16 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| D447205 | 2.5mg | $215 | Buy |
Dolutegravir Impurity 3 Chemical Properties,Uses,Production
Uses
(R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,3,4,8-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide is impurity E of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
Dolutegravir Impurity 3 Preparation Products And Raw materials
Raw materials
Preparation Products
Dolutegravir Impurity 3 Suppliers
Global( 24)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aurisco Pharmaceutical (Tianjin) Inc. | 022-59885855 | liuyujie@aurisco.com | China | 96 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-66853366 13670046396 | sales@chem-strong.com | China | 17982 | 56 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9911 | 50 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 | 3003392093@qq.com | China | 7851 | 55 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
1973402-05-9(Dolutegravir Impurity 3)Related Search:
Dolutegravir Impurity 3
(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide
(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]p
Dolutegravir Impurity 51
N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide
Dolutegravir impurity A
2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
Dolutegravir impurity 2/2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
DolutegravirImpurity9SodiumSalt
Dotiravir Impurity 3
1973402-05-9