S49076
- CAS No.
- 1265965-22-7
- Chemical Name:
- S49076
- Synonyms
- S49076;CS-2684;S4 9076;S4-9076;FGFR,S49076,Fibroblast growth factor receptor,inhibit,c-Met/HGFR,S 49076,Inhibitor,S-49076;3-((3-((4-(Morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione;(Z)-3-((3-((4-(morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 3-[[2,3-dihydro-3-[[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene]-2-oxo-1H-indol-5-yl]methyl]-
- CBNumber:
- CB53159461
- Molecular Formula:
- C22H22N4O4S
- Molecular Weight:
- 438.5
- MDL Number:
- MFCD28963943
- MOL File:
- 1265965-22-7.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO : ≥ 31 mg/mL (70.70 mM) |
| FDA UNII | 65ZUU7MATU |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
S49076 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-6191 | S49076 98.62% | 1265965-22-7 | 2mg | $72 | 2021-12-16 | Buy |
| ChemScene | CS-6191 | S49076 98.62% | 1265965-22-7 | 5mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-6191 | S49076 98.62% | 1265965-22-7 | 10mg | $156 | 2021-12-16 | Buy |
| ChemScene | CS-6191 | S49076 98.62% | 1265965-22-7 | 50mg | $540 | 2021-12-16 | Buy |
| ChemScene | CS-6191 | S49076 98.62% | 1265965-22-7 | 100mg | $972 | 2021-12-16 | Buy |
S49076 Chemical Properties,Uses,Production
Biological Activity
S49076 is a novel and potent inhibitor of Met (c-Met), AXL/MER and FGFR1/2/3 with IC50 below 20 nM.
in vivo
S49076 effectively inhibits the phosphorylation of MET, AXL and FGFRs in cells, and inhibits their downstream signaling pathways in vitro and in vivo. In cellular models, it inhibits MET and FGFR2-dependent gastric cancer cells, prevents MET-driven migration of lung cancer cells, and inhibits colony formation of liver cancer cells expressing FGFR1/2 and AXL. S49076 inhibits cell viability, motile, three-dimensional colony formation of cancer cells expressing MET, AXL or FGFRs.
in vivo
S49076 has significant antitumor activity in MET- and FGFR-dependent tumor grafts. It is highly distributed in tumors, with a half-life of approximately 7 hours in tumors and less than 2 hours in blood at a dose of 3.125 mg/kg. At doses above 6.25 mg/kg, more than 50% of MET phosphorylation was inhibited for 16 hours. S49076 was also active in a bevacizumab-resistant model, and in combination with bevacizumab, completely inhibited the growth of colon cancer xenografts.
target
| Target | Value |
| Met (Cell-free assay) | 1 nM |
| Mer (Cell-free assay) | 2 nM |
| 7 nM | |
| FGFR3 (Cell-free assay) | 15 nM |
| FGFR2 (Cell-free assay) | 17 nM |
S49076 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| ChemShuttle, Inc. | 0510-83588313-802 18800520310; | sales@chemshuttle.com | China | 3062 | 62 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4647 | 58 |
