ChemicalBook >> CAS DataBase List >>LY3214996
LY3214996
- CAS No.
- 1951483-29-6
- Chemical Name:
- LY3214996
- Synonyms
- CS-2495;LY3214996;Temuterkib;Temuterkib (LY3214996);LY-3214996 (LY3214996);LY-3214996,LY 3214996,inhibit,Extracellular signal regulated kinases,Temuterkib,Inhibitor,ERK;6,6-dimethyl-2-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one;4H-Thieno[2,3-c]pyrrol-4-one, 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-
- CBNumber:
- CB53168760
- Molecular Formula:
- C22H27N7O2S
- Molecular Weight:
- 453.56
- MDL Number:
- MFCD31544324
- MOL File:
- 1951483-29-6.mol
Last updated:2023-09-20 16:43:00
| Boiling point | 711.5±70.0 °C(Predicted) |
|---|---|
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:23.5(Max Conc. mg/mL);51.81(Max Conc. mM) Ethanol:16.0(Max Conc. mg/mL);35.28(Max Conc. mM) |
| form | A crystalline solid |
| pka | 6.58±0.10(Predicted) |
| FDA UNII | V0Q46LFE6F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H335-H302+H312+H332-H315 | |||||||||
| Precautionary statements | P301+P312-P302+P352-P305+P351+P338 | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
LY3214996 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27936 | LY3214996 | 1951483-29-6 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 27936 | LY3214996 | 1951483-29-6 | 25mg | $1026 | 2024-03-01 | Buy |
| Cayman Chemical | 27936 | LY3214996 | 1951483-29-6 | 5mg | $233 | 2024-03-01 | Buy |
| Cayman Chemical | 27936 | LY3214996 | 1951483-29-6 | 10mg | $437 | 2024-03-01 | Buy |
| ChemScene | CS-6974 | LY3214996 99.54% | 1951483-29-6 | 1mg | $80 | 2021-12-16 | Buy |
LY3214996 Chemical Properties,Uses,Production
Description
LY3214996 is an inhibitor of ERK1 and ERK2 (IC50 = 5 nM for both). It inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations. LY3214996 inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer mouse xenograft models, as well as patient-derived xenograft (PDX) mouse models.
LY3214996 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 72)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Chemtour Biotech Co., Ltd | +8617327281506 | market@chemtour.com | China | 1472 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
1951483-29-6(LY3214996)Related Search:
LY3214996
6,6-dimethyl-2-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one
CS-2495
4H-Thieno[2,3-c]pyrrol-4-one, 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-
Temuterkib
Temuterkib (LY3214996)
LY-3214996,LY 3214996,inhibit,Extracellular signal regulated kinases,Temuterkib,Inhibitor,ERK
LY-3214996 (LY3214996)
1951483-29-6