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7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin
7-Ethyl-10-hydroxycamptothecin structure
CAS No.
86639-52-3
Chemical Name:
7-Ethyl-10-hydroxycamptothecin
Synonyms
SN38;EHCPT;NK 012;SN-38:SN38;10-dihydroxy-;SN-38(NK-012); SN 38 Lactone;Irinotecan USP RC B;Irinotecan Impurity 15;7-ETHYL-10-HYDROXY-CPT
CBNumber:
CB5320664
Molecular Formula:
C22H20N2O5
Formula Weight:
392.4
MOL File:
86639-52-3.mol

7-Ethyl-10-hydroxycamptothecin Properties

Melting point:
217 °C
Boiling point:
810.3±65.0 °C(Predicted)
Density 
1.51±0.1 g/cm3(Predicted)
refractive index 
21.5 ° (C=0.2, THF)
storage temp. 
2-8°C
solubility 
DMSO: soluble1mg/mL
form 
powder
pka
9.13±0.40(Predicted)
InChIKey
FJHBVJOVLFPMQE-QFIPXVFZSA-N
CAS DataBase Reference
86639-52-3(CAS DataBase Reference)
FDA UNII
0H43101T0J
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H301
Precautionary statements  P301+P310-P261-P264-P270-P271-P280-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P403+P233-P405-P501
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  2811
WGK Germany  3
RTECS  UQ0491000
HazardClass  6.1
PackingGroup 
HS Code  29399990

7-Ethyl-10-hydroxycamptothecin price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H0165 7-Ethyl-10-hydroxycamptothecin ≥98% (HPLC), powder 86639-52-3 10mg $153 2021-03-22 Buy
Sigma-Aldrich PHR2718 Irinotecan Related Compound B Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 20?mg 86639-52-3 20MG $499 2021-03-22 Buy
Sigma-Aldrich 1347631 Irinotecan Related Compound B United States Pharmacopeia (USP) Reference Standard 86639-52-3 10mg $1160 2021-03-22 Buy
TCI Chemical E0748 7-Ethyl-10-hydroxycamptothecin >98.0%(HPLC) 86639-52-3 1g $266 2021-03-22 Buy
TCI Chemical E0748 7-Ethyl-10-hydroxycamptothecin >98.0%(HPLC) 86639-52-3 100mg $45 2021-03-22 Buy

7-Ethyl-10-hydroxycamptothecin Chemical Properties,Uses,Production

Chemical Properties

Light-Yellow Solid

Uses

A metabolite of Irinotecan, a DNA topoisomerase inhibitor

Definition

ChEBI: A member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substitu nts at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself.

Biological Activity

Active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μ M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μ M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).

7-Ethyl-10-hydroxycamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products


7-Ethyl-10-hydroxycamptothecin Suppliers

Global( 471)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Unibest Industrial Co.,Ltd.
+86-0574-27855661
+86 574 2785 6789 info@unibestcn.com China 26 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26734 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58

View Lastest Price from 7-Ethyl-10-hydroxycamptothecin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-26 7-Ethyl-10-hydroxycamptothecin 86639-52-3
86639-52-3
US $32.00 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-08-26 7-Ethyl-10-Hydroxycamptothecin
86639-52-3
US $10.70 / g/Bag 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-07-13 7-Ethyl-10-hydroxycamptothecin
86639-52-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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