BETA-POMPILIDOTOXIN
- CAS No.
- 216064-36-7
- Chemical Name:
- BETA-POMPILIDOTOXIN
- Synonyms
- β-PMTX;BETA-PMTX;β-Pompilidotoxin;β-Pompilidotoxin;b-Pompilidotoxin;RIKIGLFDQLSRL-NH2;BETA-POMPILIDOTOXIN;L-Leucinamide, L-arginyl-L-isoleucyl-L-lysyl-L-isoleucylglycyl-L-leucyl-L-phenylalanyl-L-α-aspartyl-L-glutaminyl-L-leucyl-L-seryl-L-arginyl-
- CBNumber:
- CB5324309
- Molecular Formula:
- C71H124N22O17
- Molecular Weight:
- 1557.88
- MDL Number:
- MFCD03788007
- MOL File:
- 216064-36-7.mol
BETA-POMPILIDOTOXIN price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1539 | beta-Pompilidotoxin | 216064-36-7 | 1 | $228 | 2021-12-16 | Buy |
| ApexBio Technology | A1132 | β-Pompilidotoxin | 216064-36-7 | 25mg | $280 | 2021-12-16 | Buy |
| ApexBio Technology | A1132 | β-Pompilidotoxin | 216064-36-7 | 1mg | $40 | 2021-12-16 | Buy |
| ApexBio Technology | A1132 | β-Pompilidotoxin | 216064-36-7 | 5mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A1132 | β-Pompilidotoxin | 216064-36-7 | 10mg | $200 | 2021-12-16 | Buy |
BETA-POMPILIDOTOXIN Chemical Properties,Uses,Production
Biological Activity
β-pompilidotoxin, (c71h124n22o17), a peptide with the sequence h2n-arg-ile-lys-ile-gly-leu-phe-asp-gln-leu-ser-arg-leu-amide, mw= 1557.88. pompilidotoxin is a toxin from the venom of spider wasps that slows the inactivation of na+channels. α-pompilidotoxin (α-pmtx) can be extracted from the venom of a solitary wasp, anopolis samariensis. β-pompilidotoxin (β-pmtx) originates from the venom of another wasp, batozonellus maculifrons(1). homology α-pmtx has no structural homology with other toxins. it lacks disulfide bonds which are known to be present in other toxins acting on sodium channels, such as sea anemone toxins or scorpion toxins(2). both α- and β-pmtx slow the inactivation of neuronal sodium channels (but not heart sodium channels), possibly by binding to the neurotoxin receptor site 3 on the extracellular surface of the sodium channel(3). β-pmtx has higher potency than α-pmtx. by slowing down the inactivation of sodium channels, pmtxs can potentiate synaptic transmission in the lobster neuromuscular endplate.figure1 formula of β-pompilidotoxin
References
1. Konno K, Hisada M, Itagaki Y, Naoki H, Kawai N, Miwa A, Yasuhara T, Takayama H (1998). "Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms". Biochem Biophys Res Commun. 250 (3): 612–6.2. Sahara Y, Gotoh M, Konno K, Miwa A, Tsubokawa H, Robinson HP, Kawai N (2000). "A new class of neurotoxin from wasp venom slows inactivation of sodium current". Eur J Neurosci. 12 (6): 1961–70.3. Kawai N, Konno K (2004). "Molecular determinants of two neurotoxins that regulate sodium current inactivation in rat hippocampal neurons". Neurosci Lett. 361 (1-3): 44–6.
BETA-POMPILIDOTOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
BETA-POMPILIDOTOXIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| ApexBio Technology LLC | +1-832-696-8203 | info@apexbt.com | United States | 477 | 60 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | eric@peptidego.com | China | 6119 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19105 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |