ChemicalBook >> CAS DataBase List >>PF-6260933
PF-6260933
- CAS No.
- 1811510-56-1
- Chemical Name:
- PF-6260933
- Synonyms
- PF-6260933;PF06260933;[3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)-;PF 06260933;PF06260933;PF6260933;PF 6260933;PF-6260933;inhibit,MAP4K,MAPK Kinase Kinase Kinase,PF 06260933,PF06260933,Inhibitor,PF-06260933
- CBNumber:
- CB53344890
- Molecular Formula:
- C16H13ClN4
- Molecular Weight:
- 296.75
- MDL Number:
- MFCD30532622
- MOL File:
- 1811510-56-1.mol
Last updated:2023-05-21 10:59:17
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933998090 |
PF-6260933 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-8001 | PF-06260933 98.41% | 1811510-56-1 | 5mg | $144 | 2021-12-16 | Buy |
| ChemScene | CS-8001 | PF-06260933 98.41% | 1811510-56-1 | 10mg | $228 | 2021-12-16 | Buy |
| ChemScene | CS-8001 | PF-06260933 98.41% | 1811510-56-1 | 25mg | $468 | 2021-12-16 | Buy |
| ChemScene | CS-8001 | PF-06260933 98.41% | 1811510-56-1 | 50mg | $660 | 2021-12-16 | Buy |
| ChemScene | CS-8001 | PF-06260933 98.41% | 1811510-56-1 | 100mg | $1020 | 2021-12-16 | Buy |
PF-6260933 Chemical Properties,Uses,Production
Biological Activity
PF-6260933 is a MAP4K4 inhibitor with IC50 of 3.7 nM and good kinome selectivity.
in vitro
PF-06260933 treatment of human aortic endothelial cell (EC) robustly prevents TNF-α-mediated endothelial permeability in vitro , similar to MAP4K4 knockdown.
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in vivo
In the mice model, PF-06260933 treatment does not alter plasma lipid content, although reductions in glucose levels are observed, which is consistent with whole-body-inducible Map4k4 knockout animals. PF-06260933 administration ameliorates further plaque development and/or promotes plaque regression in this animal model (46.0% versus 25.5%), and a reduction in plasma glucose as well as lipid content is also observed.
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target
| Target | Value |
| MAP4K4 () | 3.7 nM |
PF-6260933 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 43)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8017 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2987 | 58 |
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PF-6260933
[3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)-
PF06260933
PF 06260933;PF06260933;PF6260933;PF 6260933;PF-6260933
inhibit,MAP4K,MAPK Kinase Kinase Kinase,PF 06260933,PF06260933,Inhibitor,PF-06260933
1811510-56-1