Cyclizine | 82-92-8

Cyclizine Properties

Melting point	105.5-107.5°
Boiling point	399.58°C (rough estimate)
Density	0.9934 (rough estimate)
refractive index	1.5840 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Slightly soluble in water and in ethanol (96 per cent).
EWG's Food Scores	1
FDA UNII	QRW9FCR9P2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H319-H301-H335-H315
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P310-P321-P330-P405-P501

Cyclizine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S361267	1-(DIPHENYLMETHYL)-4-METHYLPIPERAZINE AldrichCPR	82-92-8	250MG	$179	2024-03-01	Buy
Matrix Scientific	058068	1-Benzhydryl-4-methylpiperazine 95%	82-92-8	25g	$140	2021-12-16	Buy
Biosynth Carbosynth	FC31349	Cyclizine Base	82-92-8	100g	$140	2021-12-16	Buy
Biosynth Carbosynth	FC31349	Cyclizine Base	82-92-8	50g	$87.5	2021-12-16	Buy
Biosynth Carbosynth	FC31349	Cyclizine Base	82-92-8	250g	$275	2021-12-16	Buy

Product number	Packaging	Price	Buy
S361267	250MG	$179	Buy
058068	25g	$140	Buy
FC31349	100g	$140	Buy
FC31349	50g	$87.5	Buy
FC31349	250g	$275	Buy

Cyclizine Chemical Properties,Uses,Production

Chemical Properties

White or almost white, crystalline powder.

Originator

Marezine,BurroughsWellcome,US,1953

Uses

Cyclizine is an antihistamine with a sedative effect used in the treatment of nausea and vomiting associated with motion sickness.

Uses

Cyclizine exhibits antihistamine and anticholinergic action and is used for vomiting and diarrhea. The exact mechanism of action is not known. Synonyms of this drug are marezine and migril.

Uses

H1 antihistamine

Preparation

Cyclizine is prepared through the alkylation of N-methylpiperazine with benzhydryl chloride.

Definition

ChEBI: An N-alkylpiperazine in which one nitrogen of the piperazine ring is substituted by a methyl group, while the other is substituted by a diphenylmethyl group.

Manufacturing Process

One-tenth mol (20 g) of benzhydryl chloride was mixed with 0.19 mol (19 g) of N-methylpiperazine and about 10 cc of benzene and the whole was heated on the steam bath four hours. The contents of the flask was partitioned between ether and water, and the ethereal layer was washed with water until the washings were neutral. The base was then extracted from the ethereal layer by N hydrochloric acid and the extract, made acid to Congo red paper, was evaporated under vacuum. 29.5 g of the pure dihydrochloride of Nmethyl-N'-benzhydryl piperazine was recovered from the residue by recrystallization from 95% alcohol melting above 250°C with decomposition. The addition of alkali to an aqueous solution of the dihydrochloride liberated the base which was recovered by recrystallization from petroleum ether melting at 105.5° to 107.5°C.

brand name

Marezine (GlaxoSmithKline).

Therapeutic Function

Antinauseant

General Description

Cyclizine hydrochloride,1-(diphenylmethyl)-4-methylpiperazine monohydrochloride(Marezine), occurs as a light-sensitive, white crystallinepowder with a bitter taste. It is slightly soluble in water(1:115), in alcohol (1:115), and in chloroform (1:75). It isused primarily in the prophylaxis and treatment of motionsickness. The lactate salt (Cyclizine Lactate Injection,United States Pharmacopoeia [USP]) is used for intramuscular(IM) injection because of the limited water solubilityof the hydrochloride. The injection should be stored in acold place, because if it is stored at room temperature forseveral months, a slight yellow tint may develop. This doesnot indicate a loss in biologic potency.

Clinical Use

It can be used not only in the treatment of allergic diseases, but also in the management of postoperative, irradiation or druginduced vomiting. Cyclizine dependence has been suggested to occur when it is used in combination with analgesics in long-term therapy. For this reason, several countries have removed cyclicine from analgesic combination preparations.

Synthesis

Cyclizine, 1-(diphenylmethyl)-4-methylpiperazine (16.1.15), is synthesized by alkylating 1-methylpiperazine with benzhydrylbromide.

Synthesis_82-92-8

Cyclizine Preparation Products And Raw materials

Raw materials

Chlorodiphenylmethane 1-Methylpiperazine

Preparation Products

Cyclizine Suppliers

Global( 66)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9409	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29322	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9427	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Healthchem co.,ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
Alfa Chemistry	58

View Lastest Price from Cyclizine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-04-13	CYCLIZINE HCL 82-92-8	US $30.00 / kg	1kg	99%	20 tons	Hebei Duling International Trade Co. LTD
	2021-06-18	Cyclizine USP/EP/BP	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited

CYCLIZINE HCL
82-92-8
US $30.00 / kg
99%
Hebei Duling International Trade Co. LTD

Cyclizine USP/EP/BP
US $1.10 / g
99.9%
Dideu Industries Group Limited

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(n-benzhydryl)(n’-methyl)diethylenediamine (N-Benzhydryl)(N'-methyl)diethylenediamine 1-(diphenylmethyl)-4-methyl-piperazin 1-Benzhydryl-4-methylpiperazine 1-Diphenylmethyl-4-methylpiperazine Bw 47-83 bw47-83 Ciclizina Compound 47-83 compound47-83 Emoquil Marazine Marezine Marzine Nautazine n-benzhydryl-n’-methylpiperazine N-Benzhydryl-N-methyl piperazine N-Benzhydryl-N'-methylpiperazine 1-DIPHENYLMETHYL-4-METHYL-PIPERAZINE HYDROCHLORIDE n-benzhydryl-n-methylpiperazine Ne-devomit Neo-devomit n-methyl-n’-benzhydrylpiperazine n-methyl-n’-benzyhydrylpiperazine N-Methyl-N'-benzhydrylpiperazine N-Methyl-N'-benzyhydrylpiperazine Piperazine, 1-(diphenylmethyl)-4-methyl- Valoid Wellcome Wellcome preparation 47-83 Wellcome prepn. 47-83 wellcomepreparation47-83 N-BENZHYDRYL-N'-METHYLPIPERAZINE HYDROCHLORIDE CYCLIZINE HCL Cyclizine (base and/or unspecified salts) CYCLYZINE Cyclizine Base Cyclizine USP/EP/BP cyclizineis1-benzhydryl-4-methylpiperazine.itcontainsnotlessthan98.5%andnotmorethan101.0%ofc18h22N2,calculatedwithreferencetothedriedsubstance Cyclizine Secreizine in methanol 82-92-8 305-25-3 Miscellaneous