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Glycidol structure
Chemical Name:
ycidoL;lycidol;EpiolOH;Glycide;GLYCIDOL;NCI-C55549;dl-Glycidol;Glycidol96%;Glycidol 96%;(RS)-Glycidol
Molecular Formula:
Formula Weight:
MOL File:

Glycidol Properties

Melting point:
-54 °C
Boiling point:
61-62 °C/15 mmHg (lit.)
1.117 g/mL at 25 °C (lit.)
vapor density 
2.15 (vs air)
vapor pressure 
0.9 mm Hg ( 25 °C)
refractive index 
n20/D 1.433(lit.)
Flash point:
178 °F
storage temp. 
Soluble in acetone, alcohol, benzene, chloroform, and ether (Weast, 1986)
Powder, Crystals or Chunks
White to light yellow-beige
Water Solubility 
Exposure limits
TLV-TWA 75 mg/m3 (25 ppm) (ACGIH); 150 mg/m3 (50 ppm) (OSHA); IDLH 500 ppm (NIOSH).
Stability Stable, but may explode on contact with strong acids, strong bases, heavy metals, heavy metal salts. May decompose on exposure to water or moist air.
CAS DataBase Reference
556-52-5(CAS DataBase Reference)
EWG's Food Scores
Proposition 65 List
2A (Vol. 77) 2000
NIST Chemistry Reference
EPA Substance Registry System
Glycidol (556-52-5)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H242-H302+H312-H315-H319-H331-H335-H341-H350-H360F
Precautionary statements  P201-P261-P280-P304+P340+P312-P308+P313-P403+P233
Hazard Codes  T
Risk Statements  45-60-21/22-23-36/37/38-68
Safety Statements  53-45-36/37-26
RIDADR  UN 2810 6.1/PG 3
WGK Germany  3
RTECS  UB4375000
Autoignition Temperature 780 °F
Hazard Note  Toxic
HazardClass  6.1(b)
PackingGroup  III
HS Code  29109000
Toxicity Acute oral LD50 for mice 431 mg/kg, rats 420 mg/kg (quoted, RTECS, 1985).

Glycidol price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 74595 (±)-Glycidol analytical standard 556-52-5 100mg $54.5 2020-08-18 Buy
Sigma-Aldrich G5809 Glycidol 96% 556-52-5 2.5kg $657 2021-03-22 Buy
Sigma-Aldrich G5809 Glycidol 96% 556-52-5 500g $180 2021-03-22 Buy
Sigma-Aldrich Y0001048 Levodropropizine impurity C European Pharmacopoeia (EP) Reference Standard 556-52-5 y0001048 $190 2020-08-18 Buy
Sigma-Aldrich G5809 Glycidol 96% 556-52-5 5g $37.6 2021-03-22 Buy

Glycidol Chemical Properties,Uses,Production


Glycidol is a chiral molecule with epoxide and primary alcohol functional groups. It is racemic mixture and exists in the dextrorotatory and the levorotatory enantiomeric forms. Several synthetic methods are available for preparation of glycidol. However, it is commercially prepared from the epoxidation of allyl alcohol with hydrogen peroxide and a catalyst (tungsten or vanadium), or from the reaction of epichlorohydrin with caustic. Glycidol has been used in the industrial synthesis of pharmaceutical products since the 1970s. However, its use for research purposes has been reported since 1956. Available information indicates that glycidol is manufactured by several companies in Japan, Germany, and the United States.

Chemical Properties

colourless liquid

Chemical Properties

Glycidol is a colorless liquid.


Glycidol is used as a stabilizer for natural oilsand vinyl polymers, as a demulsifier, and asa leveling agent for dyes.


Stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.


Glycidol is a Stabilizer in the manufacture of vinyl polymers; chemical intermediate in preparation of glycerol, glycidyl ethers, esters, and amines; in pharmaceuticals; in sanitary chemicals.


an epoxide

General Description

Odorless clear colorless liquid.

Air & Water Reactions

Sensitive to moisture.

Reactivity Profile

Glycidol is sensitive to moisture. Glycidol is also sensitive to light. Glycidol may polymerize if heated above room temperature. Glycidol may darken on storage. Stability studies of Glycidol stored for two week protected from light indicated definite decomposition at 140° F, and strongly indicated instability at 77° F. A solution of Glycidol in water was found to be unstable when stored at room temperature, even after one day in the dark. Glycidol is incompatible with strong oxidizers. Glycidol will undergo explosive decomposition in the presence of strong acids or bases, salts (such as aluminum chloride, iron(III)chloride or tin(IV) chloride) or metals (such as copper and zinc). Glycidol is also incompatible with nitrates. Glycidol will attack some forms of plastics, rubber and coatings.


Toxic material. Probable carcinogen.

Health Hazard

Glycidol is an eye, lung, and skin irri-tant. The pure compound caused severebut reversible corneal injury in rabbit eyes(ACGIH 1986). Exposure to its vapor causedirritation of lung in mice, resulting in pneu-monitis. There is no evidence of any cumula-tive toxicity. From the limited toxicity data,it appears that the health hazard to humansfrom its exposure is, primarily, respiratoryirritation, stimulation of the central nervoussystem, and depression.
Glycidol is mutagenic, testing positive inthe histidine reversion–Ames test. There isno report of its carcinogenic action. Oraland intraperitoneal administration of gly-cidol in rats showed harmful effects onfertility.

Fire Hazard

Glycidol is combustible.

Safety Profile

Confirmed carcinogen with carcinogenic data reported. Poison by intraperitoneal route. Moderately toxic by ingestion, inhalation, and sh contact. Experimental teratogenic and reproductive effects. A skin irritant. Human mutation data reported. Animal experiments suggest somewhat lower toxicity than for related epoxy compounds. Readdy absorbed through the skin. Causes nervous excitation followed by depression. Explodes when heated or in the presence of strong acids,bases, metals (e.g., copper, zinc), and metal salts (e.g., aluminum chloride, iron(II1) chloride, tin(Iy chloride). When heated to decomposition it emits acrid smoke and fumes. See also DIGLYCIDYL ETHER.

Potential Exposure

Glycidol is used as an intermediate in the synthesis of glycerol, glycidyl ethers, esters, and amines.


Glycidol is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

Chemical/Physical. May hydrolyze in water forming glycerin (Lyman et al., 1982).


UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

[S(-)-isomer, § also available on polymer support, has b 49-50o/7mm, 66-67o/19mm, [ ] D -1 5o(neat)], [R(+)-isomer has b 56 -5 6 . 5o/11mm, d 4 1.117, n D 1.429, [ ] D +15o (neat)]. Purify glycidol by fractional distillation.

Toxicity evaluation

Glycidol is a small molecule possessing a chemically reactive epoxide group. Therefore, it acts as a direct alkylating agent. Nucleophilic bioactive compounds such as glutathione react readily with glycidol. Glycidol decreases glutathione content in rat liver by direct binding to the glutathione. In vitro experiments revealed that glycidol reacts with purified DNA to form the DNA adducts. This is likely to be responsible for the genotoxic activity of the compound without a requirement for metabolic activation.


May form explosive mixture with air. Violent reaction with strong oxidizers, nitrates. Decomposes on contact (especially in the presence of heat) with strong acids, strong bases, water, metal salts, e.g., alu minum chloride, ferric chloride, and tin chloride), or metals (copper and zinc), causing fire and explosion hazard. Contact with barium, lithium, sodium, magnesium, and tita nium may cause polymerization. Attacks some plastics, rubber, and coatings.

Waste Disposal

Concentrated waste contain ing no peroxides: discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxides: perforation of a container of the waste from a safe distance followed by open burning.

Glycidol Preparation Products And Raw materials

Raw materials

Preparation Products

Glycidol Suppliers

Global( 227)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 20914 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070 CHINA 3013 60
career henan chemical co
+86-371-86658258 CHINA 29955 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58
Standardpharm Co. Ltd.
86-714-3992388 United States 14344 58
Changzhou Carman Chemical Co., Ltd.
15061933924; CHINA 514 58
Shanghai Longyu Biotechnology Co., Ltd.
+86 15821988213 China 2473 58
Chongqing Chemdad Co., Ltd
+86-13650506873 CHINA 37282 58

View Lastest Price from Glycidol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-06 Glycidol
US $1.00 / KG 1KG 99% Customized career henan chemical co

Glycidol Spectrum

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