2-Chloro-5-fluoropyrimidine
- CAS No.
- 62802-42-0
- Chemical Name:
- 2-Chloro-5-fluoropyrimidine
- Synonyms
- 2-Chloro-5-fluoropyr;Fampridine Impurity 213;2-CHLORO-5-FLUOROPYRIMIDINE;2-Chloro-5-fluoropyriMidi...;Pyrimidine,2-chloro-5-fluoro-;2-Chloro-5-fluoro-1,3-diazine;2-Chloro-5-fluoropyrimidine >2-Chloro-5-fluoropyrimidine ,98%;Pyrimidine, 2-chloro-5-fluoro- (9CI);2-Chloro-5-fluoropyrimidine ISO 9001：2015 REACH
- CBNumber:
- CB5343151
- Molecular Formula:
- C4H2ClFN2
- Molecular Weight:
- 132.52
- MDL Number:
- MFCD03788197
- MOL File:
- 62802-42-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Chloro-5-fluoropyrimidine 97% | 651753 | 1g | $183 |
| 2-Chloro-5-fluoropyrimidine 97% | 651753 | 250mg | $86.8 |
| 2-Chloro-5-fluoropyrimidine >98.0%(GC) | C2546 | 1g | $48 |
| 2-Chloro-5-fluoropyrimidine >98.0%(GC) | C2546 | 5g | $142 |
| 2-Chloro-5-fluoropyrimidine | C366450 | 25g | $1050 |
| More product size | |||
| Boiling point | 149.0-162.0°C |
|---|---|
| Density | 1.439 g/mL at 20 °C (lit.) |
| refractive index |
n |
| Flash point | 150 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -2.54±0.22(Predicted) |
| form | Liquid |
| color | Clear colorless to yellow |
| InChI | InChI=1S/C4H2ClFN2/c5-4-7-1-3(6)2-8-4/h1-2H |
| InChIKey | AGYUQBNABXVWMS-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(F)C=N1 |
| CAS DataBase Reference | 62802-42-0(CAS DataBase Reference) |
| FDA UNII | KK43K2RZ9W |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H314 | |||||||||
| Precautionary statements | P270-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-34-41-37/38 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2735 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | IRRITANT | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29335990 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-Chloro-5-fluoropyrimidine price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 651753 | 2-Chloro-5-fluoropyrimidine 97% | 62802-42-0 | 1g | $183 | 2023-06-20 | Buy |
| Sigma-Aldrich | 651753 | 2-Chloro-5-fluoropyrimidine 97% | 62802-42-0 | 250mg | $86.8 | 2023-01-07 | Buy |
| TCI Chemical | C2546 | 2-Chloro-5-fluoropyrimidine >98.0%(GC) | 62802-42-0 | 1g | $48 | 2025-07-31 | Buy |
| TCI Chemical | C2546 | 2-Chloro-5-fluoropyrimidine >98.0%(GC) | 62802-42-0 | 5g | $142 | 2025-07-31 | Buy |
| TRC | C366450 | 2-Chloro-5-fluoropyrimidine | 62802-42-0 | 25g | $1050 | 2021-12-16 | Buy |
2-Chloro-5-fluoropyrimidine Chemical Properties,Uses,Production
Chemical Properties
Colorless to light yellow liquid
Uses
2-Chloro-5-fluoropyrimidine is used to prepare 2,4-disubstituted-5-fluoropyrimidine , which is a biologically active molecule seen in anticancer agents like 5-fluorouracil.
Uses
2-Chloro-5-fluoropyrimidine can be used as a starting material for the preparation of:
5-fluoro-2-amino pyrimidines by reacting with various amines in the presence of K2CO3, via C-N bond forming reaction.
2-chloro-5-(5-fluoropyrimidin-2-yl)benzoic acid, an intermediate, which is used in the synthesis of benzamide scaffolds as potent antagonists against P2X7 receptors.
5-fluoro-2-cyano pyrimidine, a key intermediate used for the synthesis of 5-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine, as a potent inhibitor of the JAK2 kinase.
Preparation
Synthesis of 2-chloro-5-fluoropyrimidine: add 2,4-Dichloro-5-fluoropyrimidine and reducing metal powder to the solvent, stir to raise the temperature to the reaction temperature, slowly add acid dropwise, and keep the temperature until the reaction is completed Finish. Filtration, phase separation or direct evaporation of the solvent, and distillation under reduced pressure to remove the solvent to obtain 2-chloro-5-fluoropyrimidine.
Synthesis
2927-71-1
62802-42-0
Step A: Synthesis of 2-chloro-5-fluoropyrimidine To 2,4-dichloro-5-fluoropyrimidine (15.0 g, 89.8 mmol) was added tetrahydrofuran (100 mL) and zinc powder (17.6 g, 269 mmol). The reaction mixture was heated to 70 °C with vigorous stirring, followed by the slow dropwise addition of acetic acid (5.14 mL, 89.8 mmol) over a period of 1 hour. After completion of the dropwise addition, the reaction mixture was heated to reflux for 5 hours. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and filtered through a diatomaceous earth pad to remove solid impurities. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography to afford the target product 2-chloro-5-fluoropyrimidine (6.00 g, 50% yield).
References
[1] A. Dunaiskis. “LARGE SCALE SYNTHESIS OF 2-CHLORO-5-FLUOROPYRIMIDINE.” Organic Preparations and Procedures International 27 1 (1995): 600–602.
[2] A. DUNAISKIS. “ChemInform Abstract: Large Scale Synthesis of 2-Chloro-5-fluoropyrimidine.” ChemInform 26 52 (1995).
2-Chloro-5-fluoropyrimidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14359 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20171 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21615 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2161 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
View Lastest Price from 2-Chloro-5-fluoropyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-14 | 2-Chloro-5-fluoropyrimidine
62802-42-0
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-09-25 | 2-Chloro-5-fluoropyrimidine
62802-42-0
|
US $35.00-1.20 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-07-25 | 2-Chloro-5-fluoropyrimidine
62802-42-0
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2-Chloro-5-fluoropyrimidine
62802-42-0
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2-Chloro-5-fluoropyrimidine
62802-42-0
- US $35.00-1.20 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Chloro-5-fluoropyrimidine
62802-42-0
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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