Cyclophosphamide monohydrate

Cyclophosphamide monohydrate Properties

Melting point	49-51 °C (lit.)
Flash point	>230 °F
storage temp.	2-8°C
solubility	H₂O: 0.1 g/mL, clear, colorless
form	Crystals or Crystalline Powder
color	White to almost white
Water Solubility	40 g/L
Merck	14,2747
BRN	8167897
Stability	Hygroscopic
InChIKey	PWOQRKCAHTVFLB-UHFFFAOYSA-N
CAS DataBase Reference	6055-19-2(CAS DataBase Reference)
EWG's Food Scores	6
FDA UNII	8N3DW7272P
IARC	1 (Vol. 26, Sup 7, 100A) 2012
EPA Substance Registry System	Cyclophosphamide monohydrate (6055-19-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301-H340-H350-H360FD

Precautionary statements

P202-P264-P270-P280-P301+P310-P405

Hazard Codes

T

Risk Statements

45-25-61-46-36/37/38-23/24/25

Safety Statements

53-45-37/39-26

RIDADR

UN 3464 6.1/PG 3

WGK Germany

3

RTECS

RP6157750

F

10

HazardClass

6.1

PackingGroup

II

HS Code

29349990

NFPA 704

	1
2		0

Cyclophosphamide monohydrate price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	93813	Cyclophosphamide monohydrate analytical standard	6055-19-2	100mg	$69.5	2024-03-01	Buy
Sigma-Aldrich	239785	CyclophosphamideMonohydrate-CAS6055-19-2-Calbiochem Awidelyusedanti-neoplasticagentthatalsodisplaysimmunosuppressantpropert	6055-19-2	1g	$111	2024-03-01	Buy
TCI Chemical	C2236	Cyclophosphamide Monohydrate >98.0%(N)	6055-19-2	5g	$114	2024-03-01	Buy
TCI Chemical	C2236	Cyclophosphamide Monohydrate >98.0%(N)	6055-19-2	25g	$385	2024-03-01	Buy
Cayman Chemical	13849	Cyclophosphamide (hydrate) ≥98%	6055-19-2	1g	$32	2024-03-01	Buy

Product number	Packaging	Price	Buy
93813	100mg	$69.5	Buy
239785	1g	$111	Buy
C2236	5g	$114	Buy
C2236	25g	$385	Buy
13849	1g	$32	Buy

Cyclophosphamide monohydrate Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

alkylating agent in cancer therapy

Uses

An immunosuppressive, cytotoxic apoptosis inducer.

Uses

It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.

Uses

antineoplastic, alkylating agent

Uses

Cyclophosphamide monohydrate is used to treat cancers, autoimmune disorders and AL amyloidosis. It is a nitrogen mustard alkylating agent and reacts with deoxyribonucleic acid (DNA) to get its alkylated derivative. It is also involved in cancer research as a tool that induces apoptosis in tumor cells.

Definition

ChEBI: The monohydrate of cyclophosphamide.

brand name

Cytoxan (Bristol-Myers Squibb); Neosar (Sicor).

General Description

Fine white crystalline powder with a slightly bitter taste. Little or no odor.

Air & Water Reactions

Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions.

Reactivity Profile

Polymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis.

Fire Hazard

Cyclophosphamide monohydrate is probably combustible.

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Safety Profile

Confirmed human carcinogen. Poison by ingestion and intravenous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-, PO,, and NOx.

Cyclophosphamide monohydrate Preparation Products And Raw materials

Raw materials

Diethanolamine

Preparation Products

Cyclophosphamide monohydrate Suppliers

Global( 432)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Jingbo New Material Technology Co., Ltd	+8619931165850	hbjbtech@163.com	China	1000	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7613	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58

Supplier	Advantage
Hebei Jingbo New Material Technology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
Jinan Shengqi pharmaceutical Co,Ltd	58

View Lastest Price from Cyclophosphamide monohydrate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-19	Cyclophosphamide monohydrate 6055-19-2	US $35.00-1.10 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-12-29	Cyclophosphamide monohydrate 6055-19-2	US $8.00 / kg	1kg	99%	20000	Hebei Jingbo New Material Technology Co., Ltd
2023-09-06	Cyclophosphamide monohydrate 6055-19-2	US $30.00-10.00 / KG	50KG	99%	500000kg	Hebei Guanlang Biotechnology Co., Ltd.

Cyclophosphamide monohydrate
6055-19-2
US $35.00-1.10 / kg
99%
Henan Fengda Chemical Co., Ltd

Cyclophosphamide monohydrate
6055-19-2
US $8.00 / kg
99%
Hebei Jingbo New Material Technology Co., Ltd

Cyclophosphamide monohydrate
6055-19-2
US $30.00-10.00 / KG
99%
Hebei Guanlang Biotechnology Co., Ltd.

Cyclophosphamide monohydrate Spectrum

Cyclophosphamide monohydrate(6055-19-2)MS Cyclophosphamide monohydrate(6055-19-2)¹HNMR Cyclophosphamide monohydrate(6055-19-2)Raman Cyclophosphamide monohydrate(6055-19-2)IR

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2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE HYDRATE 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE MONOHYDRATE ENDOXON CYCLOPHOSPHAMIDE HYDRATE CYCLOPHOSPHAMIDE MONOHYDRATE CYCLOPHOSPHAMID MONOHYDRATE bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate N,N-BIS(2-CHLOROETHYL)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORIN-2-AMINE-2-OXIDE MONOHYDRATE n,n-bis(beta-chloroethyl)-n',o-propylenephosphoric acid ester amide monohydrate TIMTEC-BB SBB003026 > 100 Kgyclophosphamide monohydrate Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester~Cyclophosphane cyclophosphamide isopac Cyclophos phamide USP CYCLOPHOSPHAMIDE MONOHYDRATE, 98+% CyclophosphamideSterile,Usp28 Cyclophosphamidemonohaydrate CYCLOPHOSPHAMIDE 1-HYDRATE 2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, monohydrate CyclophosphaMide,awater 2-(Bis(2-chloroethyl)aMino)-1,3,2-oxazaphosphinane 2-oxide hydrate 2-oxide-N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine, hydrate (1:1) Bis(2-chloroethyl)phosphoramide cyclic propanolamide este Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester m (bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-oxide 1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridinemonohydrate 2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane2-oxidemonohydr 2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane-2-oxidemonohydra 2h-1,3,2-oxazaphosphorine,tetrahydro-2-(bis(2-chloroethyl)amino)-,2-oxide,mo -2monohydrate cyclicn’,o-propyleneesterofn,n-bis(2-chloroethyl)phosphorodiamidicacidm endoxanmonohydrate n,n-bis(2-chloroethyl)tetrahydro-2h-1,3,2-oxaphosphorin-2-amine,2-oxidemono N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphos-phorin-2-amine2-oxide n,n-bis(beta-chloroethyl)-n’,o-propylenephosphoricacidesteramidemonohydra n,n-bis(beta-chloroethyl)-n’,o-trimethylenephosphoricacidesterdiamidemono Procy-tox n,n-bis(beta-cloraethyl)n’-o-propylenphosphorildiamidmonohydratum N,N-Bis-2-chloroethyl-N’,O-propylenephosphoricesterdiamidemonohydrate n,n-di(2-chloroethyl)amino-n,o-propylenephosphoricacidesterdiamidemonohy CYCLOPHOPHAMIDEMONOHYDRATE CYCLOPHOSPHAMIDE,MONOHYDRATE,USP CYCLOPHOSPHAMIDE(HYDRATED) cyclophosphamide，CTX 2h-1,3,2-oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide, mo (bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-o xide 1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridine monohydrate 2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane 2-oxide monohydr 2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydra cyclophosphamide hydrate cyclophosphamide monohydrate endoxan monohydrate Cycloblastin Cyclophosphamide monohydrate, 97+% Cytoxan, 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide 2H-1,3,2-Oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide, monohydrate N,N-Bis(2-chloroethyl)-2-oxo-1-oxa-3-aza-2$l^{5}-phosphacyclohexan-2-amine hydrate CyclophosphamideUsp27 Cyclophosphamide monohydrate,2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan Cyclophosphamide (500 mg) (FOR U.S. SALE ONLY) Cyclophosphamide mon Cyclophosphamide (500 mg) (International Restricted Sales Item) (2S)-2-[bis(2-chloroethyl)aMino]-1,3,2$l^{5}-oxazaphosphinan-2-one CyclophosphaMide Monohydrate, 97% 1GR