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Triethylamine

Outline Uses Production Reaction Health Effects Category Toxicity grading Acute toxicity Stimulus data Explosive hazardous characteristics Flammability hazard characteristics Storage Characteristics Extinguishing agent Occupational standards
Triethylamine
Triethylamine
CAS No.
121-44-8
Chemical Name:
Triethylamine
Synonyms
TEN;TETN;(C2H5)3N;ai3-15425;Triethylamin;Trietilamina;Trethylamine;TRIEHYLAMINE;Triethylaine;Triaethylamin
CBNumber:
CB5355941
Molecular Formula:
C6H15N
Formula Weight:
101.19
MOL File:
121-44-8.mol

Triethylamine Properties

Melting point:
-115 °C
Boiling point:
90 °C
Density 
0.728
vapor density 
3.5 (vs air)
vapor pressure 
51.75 mm Hg ( 20 °C)
refractive index 
n20/D 1.401(lit.)
FEMA 
4246 | TRIETHYLAMINE
Flash point:
20 °F
storage temp. 
2-8°C
solubility 
water: soluble112g/L at 20°C
pka
10.75(at 25℃)
form 
Liquid
color 
Clear
PH
12.7 (100g/l, H2O, 15℃)(IUCLID)
explosive limit
1.2-9.3%(V)
Water Solubility 
133 g/L (20 ºC)
Merck 
14,9666
BRN 
1843166
Stability:
Stable. Extremely flammable. Readily forms explosive mixtures with air. Note low flash point. Incompatible with strong oxidizing agents, strong acids, ketones, aldehydes, halogenated hydrocarbons.
CAS DataBase Reference
121-44-8(CAS DataBase Reference)
NIST Chemistry Reference
Triethylamine(121-44-8)
EPA Substance Registry System
Ethanamine, N,N-diethyl-(121-44-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,C
Risk Statements  11-20/21/22-35
Safety Statements  3-16-26-29-36/37/39-45-61
RIDADR  UN 1296 3/PG 2
WGK Germany  1
RTECS  YE0175000
34
Hazard Note  Highly Flammable/Corrosive
TSCA  Yes
HazardClass  3
PackingGroup  II
HS Code  29211910
Hazardous Substances Data 121-44-8(Hazardous Substances Data)
Toxicity LD50 orally in rats: 0.46 g/kg (Smyth)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.

Triethylamine price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 471283 Triethylamine ≥99.5% 121-44-8 2l $152.5 2017-11-08 Buy
Sigma-Aldrich 1683559 Triethylamine United States Pharmacopeia (USP) Reference Standard 121-44-8 4x2ml $347.4 2017-11-08 Buy
TCI Chemical T0424 Triethylamine >99.0%(GC)(T) 121-44-8 25mL $14 2017-12-01 Buy
TCI Chemical T0424 Triethylamine >99.0%(GC)(T) 121-44-8 100mL $17 2017-12-01 Buy
Sigma-Aldrich 900632 Triethylamine ZerO 121-44-8 2x2ml $18.5 2017-11-08 Buy

Triethylamine Chemical Properties,Uses,Production

Outline

Triethylamine (formula: C6H15N), also known as N, N-diethylethanamine, is the most simple tri-substituted uniformly tertiary amine, having typical properties of tertiary amines, including salifying, oxidation, Hing Myers test (Hisberg reaction) for triethylamine does not respond. It is colorless to pale yellow transparent liquid, with a strong smell of ammonia, slightly fuming in the air. Boiling point: 89.5 ℃, relative density (water = 1): 0.70, the relative density (Air = 1): 3.48, slightly soluble in water, soluble in alcohol, ether. Aqueous solution is alkaline, flammable. Vapor and air can form explosive mixtures, the explosion limit is 1.2% to 8.0%. It is toxic, with a strong irritant.

Uses

Triethylamine is a clear, colorless liquid with an Ammonia or fish-like odor. It is used in making waterproofing agents, and as a catalyst, corrosion inhibitor and propellant.
It is mainly used as base, catalyst, solvent and raw material in organic synthesis and is generally abbreviated as Et3N, NEt3 or TEA. It can be used to prepare phosgene polycarbonate catalyst, polymerization inhibitor of tetrafluoroethylene, rubber vulcanization accelerator, special solvent in paint remover, enamel anti-hardener, surfactant, antiseptic, wetting agent, bactericides, ion exchange resins, dyes, fragrances, pharmaceuticals, high-energy fuels, and liquid rocket propellants, as a curing and hardening agent for polymers and for the desalination of seawater.
Consumption Quota of in medical industry:
Medicine Consumption Quota(Unit: t/t)
Ampicillin sodium 0.465
Amoxicillin 0.391
Cefazolin sodium 2.442
Cefazolin organism 1.093
Oxygen piperazine penicillin 0.584
Ketoconazole 8.00
Vitamin B6 0.502
Fluorine organism acid 10.00
Praziquantel 0.667
Thiotepa 1.970
Penicillamine 1.290
Berberine hydrochloride 0.030
Verapamil 0.540
Alprazolam 3.950
Adjacent benzene acetic acid 0.010

Production

It is produced by ethanol and ammonia in the presence of hydrogen, in containing Cu-Ni-clay catalyst reactor under heating conditions (190 ± 2 ℃ and 165 ± 2 ℃) reaction. The reaction also produces ethylamine and diethylamine, products were condensed and then absorption by ethanol spray to obtain crude triethylamine, through the final separation, dehydration and fractionation, pure triethylamine is obtained.

Reaction


Health Effects

Triethylamine can affect you when inhaled and by passing through the skin.
  1. Contact can severely irritate and bum the skin and eyes with possible eye damage.
  2. Exposure can irritate the eyes, nose and throat.
  3. Inhaling Triethylamine can irritate the lungs. Higher exposures may cause a build-up of fluid in the lungs (pulmonary edema), a medical mergency.
  4. Triethylamine may cause a skin allergy.
  5. Triethylamine may affect the liver and kidneys.
  6. Triethylamine is a flammable liquid and a dangerous fire hazard.

Category

Flammable liquids

Toxicity grading

Toxic

Acute toxicity

Oral-rat LD50: 460 mg/kg; Oral-Mouse LD50: 546 mg/kg

Stimulus data

Eyes-rabbit 250 mg severe

Explosive hazardous characteristics

Mixed with air can be explosive

Flammability hazard characteristics

In case of fire, high temperature, oxidant, it is flammable, combustion produces toxic fumes of nitrogen oxides

Uses

Catalytic solvent in chemical synthesis; accelerator activators for rubber; wetting, penetrating, and waterproofing agents of quaternary ammonium types; curing and hardening of polymers (e.g., corebinding resins); corrosion inhibitor; propellant.

Definition

ChEBI: A tertiary amine that is ammonia in which each hydrogen atom is substituted by an ethyl group.

Storage Characteristics

Treasury ventilation low-temperature drying, stored separately from oxidants, acids

Extinguishing agent

Dry, dry sand, carbon dioxide, foam

Occupational standards

TWA 40 mg/cubic meter

General Description

A clear colorless liquid with a strong ammonia to fish-like odor. Flash point 20°F. Vapors irritate the eyes and mucous membranes. Less dense (6.1 lb / gal) than water. Vapors heavier than air. Produces toxic oxides of nitrogen when burned.

Reactivity Profile

Triethylamine reacts violently with oxidizing agents. Reacts with Al and Zn. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

Vapors irritate nose, throat, and lungs, causing coughing, choking, and difficult breathing. Contact with eyes causes severe burns. Clothing wet with chemical causes skin burns.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Purification Methods

Dry triethylamine with CaSO4, LiAlH4, Linde type 4A molecular sieves, CaH2, KOH, or K2CO3, then distil it, either alone or from BaO, sodium, P2O5 or CaH2. It has also been distilled from zinc dust, under nitrogen. To remove traces of primary and secondary amines, triethylamine has been refluxed with acetic anhydride, benzoic anhydride, phthalic anhydride, then distilled, refluxed with CaH2 (ammonia-free) or KOH (or dried with activated alumina), and again distilled. Another purification method involved refluxing for 2hours with p-toluenesulfonyl chloride, then distilling. Grovenstein and Williams [J Am Chem Soc 83 412 1961] treated triethylamine (500mL) with benzoyl chloride (30mL), filtered off the precipitate, and refluxed the liquid for 1hour with a further 30mL of benzoyl chloride. After cooling, the liquid was filtered, distilled, and allowed to stand for several hours with KOH pellets. It was then refluxed with, and distilled from, stirred molten potassium. Triethylamine has been converted to its hydrochloride (see brlow), crystallised from EtOH (to m 254o), then liberated with aqueous NaOH, dried with solid KOH and distilled from sodium under N2. [Beilstein 4 H 99, 4 I 348, 4 II 593, 4 III 194, 4 IV 322.]

Triethylamine Preparation Products And Raw materials

Raw materials

Preparation Products


Triethylamine Suppliers

Global( 375)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
inquiry@dakenchem.com CHINA 22128 58
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0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
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86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1428 55
Secco work (Beijing) chemical technology co., LTD 010-69755668;
010-69755668 1139670422@qq.com China 3545 54
Shanghai Macklin Biochemical Co.,Ltd. 15221275939
021-51821727 shenlinxing@macklin.cn China 15834 55
Ring Specialty Chemicals Inc. +1 416 493 6870
+1 416 499 9759 info@ringchemicals.com Canada 52 58
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44192 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 25126 65

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