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Triethylamine

Outline Uses Production Reaction Health Effects Category Toxicity grading Acute toxicity Stimulus data Explosive hazardous characteristics Flammability hazard characteristics Storage Characteristics Extinguishing agent Occupational standards
Triethylamine
Triethylamine structure
CAS No.
121-44-8
Chemical Name:
Triethylamine
Synonyms
TEN;TETN;Et3N;(C2H5)3N;ai3-15425;Trietilamina;Triethylamin;Trethylamine;Triethylaine;TRIEHYLAMINE
CBNumber:
CB5355941
Molecular Formula:
C6H15N
Formula Weight:
101.19
MOL File:
121-44-8.mol

Triethylamine Properties

Melting point:
-115 °C
Boiling point:
90 °C
Density 
0.728
vapor density 
3.5 (vs air)
vapor pressure 
51.75 mm Hg ( 20 °C)
refractive index 
n20/D 1.401(lit.)
FEMA 
4246 | TRIETHYLAMINE
Flash point:
20 °F
storage temp. 
2-8°C
solubility 
water: soluble112g/L at 20°C
pka
10.75(at 25℃)
form 
Liquid
color 
Clear
Specific Gravity
0.725 (20/4℃)
Relative polarity
1.8
PH
12.7 (100g/l, H2O, 15℃)(IUCLID)
Odor
Strong ammonia-like odor
Odor Threshold
0.0054ppm
Evaporation Rate
5.6
explosive limit
1.2-9.3%(V)
Water Solubility 
133 g/L (20 ºC)
JECFA Number
1611
Merck 
14,9666
BRN 
1843166
Henry's Law Constant
1.79 at 25 °C (Christie and Crisp, 1967)
Exposure limits
NIOSH REL: IDLH 200 ppm; OSHA PEL: TWA 25 ppm (100 mg/m3); ACGIH TLV: TWA 1 ppm, STEL 3 ppm (adopted).
Stability:
Stable. Extremely flammable. Readily forms explosive mixtures with air. Note low flash point. Incompatible with strong oxidizing agents, strong acids, ketones, aldehydes, halogenated hydrocarbons.
InChIKey
ZMANZCXQSJIPKH-UHFFFAOYSA-N
CAS DataBase Reference
121-44-8(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
TRIETHYLAMINE
EWG's Food Scores
5-6
FDA UNII
VOU728O6AY
NIST Chemistry Reference
Triethylamine(121-44-8)
EPA Substance Registry System
Triethylamine (121-44-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS02,GHS05,GHS06
Signal word  Danger
Hazard statements  H312-H332-H225-H302-H311+H331-H314-H335
Precautionary statements  P210-P261-P280-P303+P361+P353-P305+P351+P338-P370+P378-P304+P340+P310-P403+P235-P310-P403+P233-P260h-P405-P501a
Hazard Codes  F,C
Risk Statements  11-20/21/22-35
Safety Statements  3-16-26-29-36/37/39-45-61
RIDADR  UN 1296 3/PG 2
WGK Germany  1
RTECS  YE0175000
34
Autoignition Temperature 593 °F
Hazard Note  Highly Flammable/Corrosive
TSCA  Yes
HazardClass  3
PackingGroup  II
HS Code  29211910
Toxicity LD50 orally in rats: 0.46 g/kg (Smyth)
NFPA 704
3
3 0

Triethylamine price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 471283 Triethylamine ≥99.5% 121-44-8 2l $150 2019-12-02 Buy
Sigma-Aldrich 1683559 Triethylamine United States Pharmacopeia (USP) Reference Standard 121-44-8 4x2ml $352.8 2019-12-02 Buy
TCI Chemical T0424 Triethylamine >99.0%(GC)(T) 121-44-8 25mL $15 2019-12-02 Buy
TCI Chemical T0424 Triethylamine >99.0%(GC)(T) 121-44-8 100mL $16 2019-12-02 Buy
Alfa Aesar 012391 Triethylamine 99+% 121-44-8 250g $36.4 2019-12-02 Buy

Triethylamine Chemical Properties,Uses,Production

Outline

Triethylamine (formula: C6H15N), also known as N, N-diethylethanamine, is the most simple tri-substituted uniformly tertiary amine, having typical properties of tertiary amines, including salifying, oxidation, Hing Myers test (Hisberg reaction) for triethylamine does not respond. It is colorless to pale yellow transparent liquid, with a strong smell of ammonia, slightly fuming in the air. Boiling point: 89.5 ℃, relative density (water = 1): 0.70, the relative density (Air = 1): 3.48, slightly soluble in water, soluble in alcohol, ether. Aqueous solution is alkaline, flammable. Vapor and air can form explosive mixtures, the explosion limit is 1.2% to 8.0%. It is toxic, with a strong irritant.

Uses

Triethylamine is a clear, colorless liquid with an Ammonia or fish-like odor. It is used in making waterproofing agents, and as a catalyst, corrosion inhibitor and propellant.
It is mainly used as base, catalyst, solvent and raw material in organic synthesis and is generally abbreviated as Et3N, NEt3 or TEA. It can be used to prepare phosgene polycarbonate catalyst, polymerization inhibitor of tetrafluoroethylene, rubber vulcanization accelerator, special solvent in paint remover, enamel anti-hardener, surfactant, antiseptic, wetting agent, bactericides, ion exchange resins, dyes, fragrances, pharmaceuticals, high-energy fuels, and liquid rocket propellants, as a curing and hardening agent for polymers and for the desalination of seawater.
Consumption Quota of in medical industry:
Medicine
Consumption Quota(Unit: t/t)
Ampicillin sodium
0.465
Amoxicillin
0.391
Cefazolin sodium
2.442
Cefazolin organism
1.093
Oxygen piperazine penicillin
0.584
Ketoconazole
8.00
Vitamin B6
0.502
Fluorine organism acid
10.00
Praziquantel
0.667
Thiotepa
1.970
Penicillamine
1.290
Berberine hydrochloride
0.030
Verapamil
0.540
Alprazolam
3.950
Adjacent benzene acetic acid
0.010

Production

It is produced by ethanol and ammonia in the presence of hydrogen, in containing Cu-Ni-clay catalyst reactor under heating conditions (190 ± 2 ℃ and 165 ± 2 ℃) reaction. The reaction also produces ethylamine and diethylamine, products were condensed and then absorption by ethanol spray to obtain crude triethylamine, through the final separation, dehydration and fractionation, pure triethylamine is obtained.

Reaction


Health Effects

Triethylamine can affect you when inhaled and by passing through the skin.
  1. Contact can severely irritate and bum the skin and eyes with possible eye damage.
  2. Exposure can irritate the eyes, nose and throat.
  3. Inhaling Triethylamine can irritate the lungs. Higher exposures may cause a build-up of fluid in the lungs (pulmonary edema), a medical mergency.
  4. Triethylamine may cause a skin allergy.
  5. Triethylamine may affect the liver and kidneys.
  6. Triethylamine is a flammable liquid and a dangerous fire hazard.

Category

Flammable liquids

Toxicity grading

Toxic

Acute toxicity

Oral-rat LD50: 460 mg/kg; Oral-Mouse LD50: 546 mg/kg

Stimulus data

Eyes-rabbit 250 mg severe

Explosive hazardous characteristics

Mixed with air can be explosive

Flammability hazard characteristics

In case of fire, high temperature, oxidant, it is flammable, combustion produces toxic fumes of nitrogen oxides

Storage Characteristics

Treasury ventilation low-temperature drying, stored separately from oxidants, acids

Extinguishing agent

Dry, dry sand, carbon dioxide, foam

Occupational standards

TWA 40 mg/cubic meter

Chemical Properties

Triethylamine is a colorless liquid. Strong ammonia odor.

Chemical Properties

Colorless to yellowish liquid; fishy aroma.

Physical properties

Clear, colorless to light yellow flammable liquid with a strong, penetrating, ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were <400 μg/m3 (<100 ppbv) and 1.1 mg/m3 (270 ppbv), respectively (Hellman and Small, 1974). An odor threshold concentration of 0.032 ppbv was determined by a triangular odor bag method (Nagata and Takeuchi, 1990).

Uses

Catalytic solvent in chemical synthesis; accelerator activators for rubber; wetting, penetrating, and waterproofing agents of quaternary ammonium types; curing and hardening of polymers (e.g., corebinding resins); corrosion inhibitor; propellant.

Definition

ChEBI: A tertiary amine that is ammonia in which each hydrogen atom is substituted by an ethyl group.

Production Methods

Triethylamine is prepared by a vapor phase reaction of ammonia with ethanol or reaction of N,N-diethylacetamide with lithium aluminum hydride (Windholz et al 1983). It may also be produced from ethyl chloride and ammonia under heat and pressure (Hawley 1981) or by vapor phase alkylation of ammonia with ethanol (HSDB 1988). U.S. production is estimated at greater than 22,000 tons in 1972 (HSDB 1988).

Aroma threshold values

High strength odor, fishy type; recommend smelling in a 0.01% solution or less.

General Description

A clear colorless liquid with a strong ammonia to fish-like odor. Flash point 20°F. Vapors irritate the eyes and mucous membranes. Less dense (6.1 lb / gal) than water. Vapors heavier than air. Produces toxic oxides of nitrogen when burned.

Reactivity Profile

Triethylamine reacts violently with oxidizing agents. Reacts with Al and Zn. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

Vapors irritate nose, throat, and lungs, causing coughing, choking, and difficult breathing. Contact with eyes causes severe burns. Clothing wet with chemical causes skin burns.

Health Hazard

Eye irritation and corneal edema have been reported from exposures in industry (Beard and Noe, 1981; Akesson et al 1985). Triethylamine may also be irritating to skin and mucous membranes (Windholz et al 1983).

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Industrial uses

Triethylamine is used as an anti-livering agent for urea- and melamine-based enamels and in the recovery of gelled paint vehicles (HSDB 1988). It is also used as a catalyst for polyurethane foams, a flux for copper soldering, and as a catalytic solvent in chemical synthesis (Hawley 1981). Triethylamine is used in accelerating activators for rubber; as a corrosion inhibitor for polymers; a propellant; wetting, penetrating, and waterproofing agent of quaternary ammonium compounds; in curing and hardening of polymers (i.e. core-binding resins); and as a catalyst for epoxy resins (Hamilton and Hardy, 1974).

Safety Profile

Moderately toxic by ingestion and skin contact. Mildly toxic by inhalation. Human systemic effects: visual field changes. Experimental reproductive effects. Mutation data reported. A skin and severe eye irritant. Can cause kidney and liver damage. A very dangerous fire hazard when exposed to heat, flame, or oxidizers. Explosive in the form of vapor when exposed to heat or flame. Complex with dinitrogen tetraoxide explodes below 0°C when undduted with solvent. Exothermic reaction with maleic anhydride above 150°C. Can react with oxidzing materials. Incompatible with N2O4. To fight fire, use CO2, dry chemical, alcohol foam. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

Triethylamine is and aliphatic amine used as a solvent; corrosion inhibitor; in chemical synthesis; and accelerator activators; paint remover; base in methylene chloride or other chlorinated solvents. TEA is used to solubilize 2,4,5-T in water and serves as a selective extractant in the purification of antibiotics. It is used to manufacture quaternary ammonia compounds and octadecyloxymethyltriethylammonium chloride; an agent used in textile treatment.

Environmental Fate

Photolytic. Low et al. (1991) reported that the photooxidation of aqueous tertiary amine solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium and nitrate ions.
Chemical/Physical. Triethylamine reacted with NOx in the dark to form diethylnitrosamine. In an outdoor chamber, photooxidation by natural sunlight yielded the following products: diethylnitramine, diethylformamide, diethylacetamide, ethylacetamide, diethylhydroxylamine, ozone, acetaldehyde, and peroxyacetyl nitrate (Pitts et al., 1978).

Metabolism

There have been few studies on the metabolism of industrially important aliphatic amines such as triethylamine. It is generally assumed that amines not normally present in the body are metabolized by monoamine oxidase and diamine oxidase (histaminase).
Ultimately ammonia is formed and will be converted to urea. The hydrogen peroxide formed is acted upon by catalase and the aldehyde formed is thought to be converted to the corresponding carboxylic acid by the action of aldehyde oxidase (Beard and Noe 1981).

Shipping

UN1296 Triethylamine, Hazard Class: 3; Labels: 3-Flammable liquid, 8-Corrosive material.

Purification Methods

Dry triethylamine with CaSO4, LiAlH4, Linde type 4A molecular sieves, CaH2, KOH, or K2CO3, then distil it, either alone or from BaO, sodium, P2O5 or CaH2. It has also been distilled from zinc dust, under nitrogen. To remove traces of primary and secondary amines, triethylamine has been refluxed with acetic anhydride, benzoic anhydride, phthalic anhydride, then distilled, refluxed with CaH2 (ammonia-free) or KOH (or dried with activated alumina), and again distilled. Another purification method involved refluxing for 2hours with p-toluenesulfonyl chloride, then distilling. Grovenstein and Williams [J Am Chem Soc 83 412 1961] treated triethylamine (500mL) with benzoyl chloride (30mL), filtered off the precipitate, and refluxed the liquid for 1hour with a further 30mL of benzoyl chloride. After cooling, the liquid was filtered, distilled, and allowed to stand for several hours with KOH pellets. It was then refluxed with, and distilled from, stirred molten potassium. Triethylamine has been converted to its hydrochloride (see brlow), crystallised from EtOH (to m 254o), then liberated with aqueous NaOH, dried with solid KOH and distilled from sodium under N2. [Beilstein 4 H 99, 4 I 348, 4 II 593, 4 III 194, 4 IV 322.]

Incompatibilities

A strong base. Violent reaction with strong acids; halogenated compounds; and strong oxidizers. Attacks some forms of plastics, rubber and coatings. Corrosive to aluminum, zinc, copper, and their alloys in the presence of moisture. Reaction with nitrosating agents (e.g., nitrites, nitrous gases, and nitrous acid) capable of releasing carcinogenic nitrosamines.

Waste Disposal

Controlled incineration (incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions).

Triethylamine Preparation Products And Raw materials

Raw materials

Preparation Products


Triethylamine Suppliers

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View Lastest Price from Triethylamine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-11-20 Triethylamine
121-44-8
US $10.00 / KG 1KG 99.9% 100tons Hebei Guanlang Biotechnology Co., Ltd.
2020-04-21 Triethylamine
121-44-8
US $1.00 / KG 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
2019-11-25 Triethylamine
121-44-8
US $99.00 / KG 1KG 99% 100 Ton/Tons per Month Hebei Xibaijie Biotechnology Co., Ltd.

Triethylamine Spectrum


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