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ChemicalBook >> CAS DataBase List >>11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2

11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2

11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 Structure
11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 structure
CAS No.
958759-75-6
Chemical Name:
11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2
Synonyms
SAAKCJFTIGHOEX-WQXLGBCHSA-N;11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2;9ALPHA,HYDROXY-11-METHYLENE-15-OXO-PROSTA-5Z,13E-DIEN-1-OIC ACID;Prosta-5,13-dien-1-oic acid, 9-hydroxy-11-methylene-15-oxo-, (5Z,9α,13E)-
CBNumber:
CB5356524
Molecular Formula:
C21H32O4
Molecular Weight:
348.48
MDL Number:
MFCD05863942
MOL File:
Mol file
Last updated:2023-06-08 09:02:10
Product description Number Pack Size Price
11-deoxy-11-methylene-15-keto Prostaglandin D2 ≥98% 12415 100μg $48
11-deoxy-11-methylene-15-keto Prostaglandin D2 ≥98% 12415 500μg $216
11-deoxy-11-methylene-15-keto Prostaglandin D2 ≥98% 12415 1mg $384
Request For Quotation

11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 Properties

solubility DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): 2 mg/ml

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07,GHS08
Signal word  Danger
NFPA 704
3
2 0

11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 12415 11-deoxy-11-methylene-15-keto Prostaglandin D2 ≥98% 958759-75-6 100μg $48 2021-12-16 Buy
Cayman Chemical 12415 11-deoxy-11-methylene-15-keto Prostaglandin D2 ≥98% 958759-75-6 500μg $216 2021-12-16 Buy
Cayman Chemical 12415 11-deoxy-11-methylene-15-keto Prostaglandin D2 ≥98% 958759-75-6 1mg $384 2021-12-16 Buy
Product number Packaging Price Buy
12415 100μg $48 Buy
12415 500μg $216 Buy
12415 1mg $384 Buy

11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 Chemical Properties,Uses,Production

Description

Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. Many of the biological effects of PGD2 are transduced in vivo by a classical 7-transmembrane GPCR, the DP1 receptor.1 However, a second receptor, the chemokine-related CRTH2 receptor, also binds PGD2.2,3 This new receptor was recently identified on human eosinophils, where it binds selectively the PGD2 metabolite 13,14-dihydro-15-keto PGD2.4 11-deoxy-11-methylene-15-keto PGD2 was prepared as a more chemically stable ligand for this receptor. There are no published studies of the pharmacological properties of 11-deoxy-11-methylene-15-keto PGD2.

Definition

ChEBI: 11-Deoxy-11-methylene-15-keto-PGD2 is a prostanoid.

References

1. Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor J. Biol. Chem. 270(32),18910-18916(1995).
2. Gervais, F.G., Cruz, R., Chateauneuf, A., et al. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP J. Allergy Clin. Immunol. 108(6),982-988(2002).
3. Monneret, G., Gravel, S., Diamond, M., et al. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor Blood 98(6),1942-1948(2001).
4. Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2 J. Exp. Med. 193(2),255-261(2001).

11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 Preparation Products And Raw materials

Raw materials

Preparation Products

11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
Santa Cruz Biotechnology Inc 021-60936350 scbt@scbt.com China 6594 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
Santa Cruz Biotechnology Inc 58
9ALPHA,HYDROXY-11-METHYLENE-15-OXO-PROSTA-5Z,13E-DIEN-1-OIC ACID 11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 SAAKCJFTIGHOEX-WQXLGBCHSA-N Prosta-5,13-dien-1-oic acid, 9-hydroxy-11-methylene-15-oxo-, (5Z,9α,13E)- 958759-75-6