FENOVERINE
- CAS No.
- 37561-27-6
- Chemical Name:
- FENOVERINE
- Synonyms
- FENOVERINE;Spasmopriv;Fenoverine D8;3-chloro-3-oxopropanoic acid ethyl ester;10-[(4-Piperonyl-1-piperazinyl)acetyl]-10H-phenothiazine;Ethanone, 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-1-(10H-phenothiazin-10-yl)-
- CBNumber:
- CB5362347
- Molecular Formula:
- C26H25N3O3S
- Molecular Weight:
- 459.56
- MDL Number:
- MFCD00865242
- MOL File:
- 37561-27-6.mol
- MSDS File:
- SDS
| Melting point | 141-142° |
|---|---|
| Boiling point | 671.8±55.0 °C(Predicted) |
| Density | 1.343±0.06 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 6.47±0.10(Predicted) |
| form | Solid |
| color | Pale Beige to Beige |
| Stability | Hygroscopic |
| FDA UNII | N274ZQ6PZJ |
| ATC code | A03AX05 |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in mice (g/kg): ~1.50 orally, ~2.50 i.p. (Buzas, Pierre) |
|---|
FENOVERINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | F248898 | Fenoverine | 37561-27-6 | 50mg | $95 | 2021-12-16 | Buy |
| TRC | F248898 | Fenoverine | 37561-27-6 | 250mg | $380 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0011437 | FENOVERINE 95.00% | 37561-27-6 | 5MG | $500.9 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 18631 | Fenoverine | 37561-27-6 | 5mg | $950 | 2021-12-16 | Buy |
FENOVERINE Chemical Properties,Uses,Production
Originator
Spasmopriv,Paillusseau
Uses
Fenoverine is a colon-specific multi particulate drug. Also, it is an antispasmodic drug which inhibits contraction of smooth muscle. It is derived from Phenothiazine (P318040), which is a key component of antipsychotic and antihistaminic drugs.
Definition
ChEBI: Fenoverine is a member of phenothiazines.
Manufacturing Process
To a hot solution 199.3 g (0.1 mol) of phenothiazine in 2 L of dry benzene
was added a little quantity of bromine and then were added dropwise 136 g
(0.1 mol) of chloroacetyle chloride. Then a mixture was refluxed for 5 hours.
After cooling the mixture was concentrated in vacuo. Product was dissolved at
reflux in ethanol absolute and filtered. At room temperature was crystallized
chloracetyl-10-phenothiazine with 123°C; yield 242 g.
A mixture of 13.8 g (0.05 mol) of chloracetyl-10-phenothiazine, 11.8 g (0.05
mol) of piperonyl-1-piperazine and 3.9 g (0.05 mol) of pyridine in 200 ml of
dry toluene was refluxed for 3 hours. Then the solution was cooled and
filtered. The filtrate was concentrated. The crystals of 10-((4-piperonyl-1-
piperazinyl)acetyl)phenothiazine was recrystallized from isopropylic ether; M.P.
141-142°C; yield 67%.
Therapeutic Function
Spasmolytic
FENOVERINE Preparation Products And Raw materials
FENOVERINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Cdreamlab (Hubei) Technology Co., LTD | 0717-6300888 18062399888 | service@cdreamlab.com | China | 315 | 58 |
| Cdreamlab (Hubei) Technology Co., LTD | 0717-6300888 18062399888 | service@cdreamlab.com | China | 265 | 58 |
| Supplier | Advantage |
|---|---|
| PT CHEM GROUP LIMITED | 58 |
| Amadis Chemical Company Limited | 58 |
| LGM Pharma | 70 |
| TargetMol Chemicals Inc. | 58 |
| Cdreamlab (Hubei) Technology Co., LTD | 58 |
| Cdreamlab (Hubei) Technology Co., LTD | 58 |