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LACTITOL structure
Chemical Name:
Lactit;Lactnol;Lactite;LACTITOL;Importal;Lactit M;Lactosit;Finlac DC;D-Lactitol;Lactiobiosit
Molecular Formula:
Formula Weight:
MOL File:

LACTITOL Properties

Melting point:
D23 +14° (c = 4 in water)
Boiling point:
788.5±60.0 °C(Predicted)
1.69±0.1 g/cm3(Predicted)
Slightly soluble in ethanol (95%) and ether. Soluble 1 in 1.75 of water at 20°C; 1 in 1.61 at 30°C; 1 in 1.49 at 40°C; 1 in 1.39 at 50°C.
EWG's Food Scores
ATC code

LACTITOL price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1356687 Lactitol United States Pharmacopeia (USP) Reference Standard 585-86-4 500 mg $414 2021-12-16 Buy
TRC L113550 Lactitol 585-86-4 5g $150 2021-12-16 Buy
TRC L113550 Lactitol 585-86-4 1g $110 2021-12-16 Buy
Usbiological 297326 Lactitol anhydrous 585-86-4 1kg $340 2021-12-16 Buy
Biosynth Carbosynth OL09821 Lactitol anhydrous 585-86-4 500 mg $75 2021-12-16 Buy

LACTITOL Chemical Properties,Uses,Production


Lactitol (4-o-(|3-D-Galactopyranosyl)-D-glucitol) is a disaccharide sugar alcohol derived from lactose by reduction of its glucose moiety. Lactitol has not been found in nature. It is about 0.4 times as sweet as sucrose.
In vitro studies with galactosidase-containing enzyme preparations have demonstrated that lactitol is hydrolyzed only very slowly. In incubations with human intestinal biopsies, it has been shown that the human intestinal mucosa does not exhibit any significant dis accharidase activity with lactitol as a substrate. The hydrolytic activities towards lactitol and isomalt were only 1.3% of those towards lactose and isomaltulose, respectively. Corresponding exper iments with intestinal preparations of germ-free pigs and convention ally kept minipigs gave similar results. These observations indicate that lactitol is the most slowly digested disaccharide sugar alcohol. However, in vitro investigations with intestinal enzyme prepara tions provide only relative figures on hydrolysis rates. Experiments with humans and 14C-labeled lactitol during jejunal perfusion indi cate that lactitol is virtually not assimilated by the human small intestine. After passage through the small intestine, ingested lac titol reaches the bacterially colonized segments of the gut where intensive fermentation takes place. Short-chain fatty acids (acetate, propionate, butyrate) are the major fermentation end products which are subsequently further metabolized by the host.
Lactitol is slowly fermented in growing cultures by some strepto cocci, actinomyces and lactobacilli. When fed at 25% of the diet to rats that had been inoculated with Streptococcus mutans, lactitol was about equally as cariogenic as sorbitol and significantly less cariogenic than sucrose. Test candies and chocolates sweetened by lactitol are hypoacidogenic in humans tested by plaque pH telemetry. Boiled sweets made with 100% lactitol are rough in texture owing to crystallization, and caused some gastrointestinal upsets in human volunteers. Since lactitol has only one-third the sweetness of sucrose, sweets need an additional sweetening agent for palatability.

Chemical Properties

Lactitol occurs as white orthorhombic crystals. It is odorless with a sweet taste that imparts a cooling sensation. It is available in powdered form and in a range of crystal sizes. The directly compressible form is a water-granulated product of microcrystalline aggregates.


Lactitol is listed as an excipient in some prescription drugs, such as Adderall. Lactitol is a sugar alcohol used as a replacement bulk sweetener for low calorie foods. It is also used medically as a laxative.

Production Methods

Lactitol is produced by the catalytic hydrogenation of lactose.

Pharmaceutical Applications

Lactitol is used as a noncariogenic replacement for sucrose. It is also used as a diluent in solid dosage forms.(1) A direct-compression form is available,(2,3) as is a direct-compression blend of lactose and lactitol. Lactitol is also used therapeutically in the treatment of hepatic encephalopathy and as a laxative.


Lactitol is regarded as a nontoxic and nonirritant substance. It is not fermented significantly in the mouth, and is not cariogenic.It is not absorbed in the small intestine, but is broken down by microflora in the large intestine, and is metabolized independently of insulin. In large doses it has a laxative effect; therapeutically, 10–20 g daily in a single oral dose is administered for this purpose.
LD50 (mouse, oral): >23 g/kg
LD50 (rat, oral): 30 g/kg


Lactitol as the monohydrate is nonhygroscopic and is stable under humid conditions. It is stable to heat and does not take part in the Maillard reaction. In acidic solution, lactitol slowly hydrolyzes to sorbitol and galactose. Lactitol is very resistant to microbiological breakdown and fermentation. Store in a well-closed container. When the compound is stored in an unopened container at 25°C and 60% relative humidity, a shelf-life in excess of 3 years is appropriate.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

LACTITOL Preparation Products And Raw materials

Raw materials

Preparation Products

LACTITOL Suppliers

Global( 148)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418697 China 3000 55
hdzhl biotechnology co., ltd
86-13032617415 CHINA 1275 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037 CHINA 3000 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58
BOC Sciences
1-631-614-7828 United States 19752 58
0371-55170695 CHINA 26742 58
86-18523575427 China 47498 58
career henan chemical co
15093356674 0371-55982848
0086-371-86658258 CHINA 29864 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu CHINA 13187 58
Jinan Qinmu Fine Chemical Co.,Ltd.
18660799346 18363098612
+86 531 8316 6650 CHINA 1009 58

View Lastest Price from LACTITOL manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-15 Lactitol
US $2.00 / KG 1000KG 99% 5ton/Month Hebei Yirun Sega Biological Technology Co. Ltd
2021-09-29 Lactitol
US $0.00 / KG 1KG 99.0% 10tons/month WUHAN FORTUNA CHEMICAL CO., LTD
2021-07-13 LACTITOL
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd


585-86-4(LACTITOL)Related Search:

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