ANISOMYCIN
- CAS No.
- 22862-76-6
- Chemical Name:
- ANISOMYCIN
- Synonyms
- Nsc76712;Nsc147340;Aids031977;ANISOMYCIN;FLAGECIDIN;Aids-031977;Wuningmeisu C;4-beta))-alph;Anisomycin>(-)-anisomycin
- CBNumber:
- CB5363672
- Molecular Formula:
- C14H19NO4
- Molecular Weight:
- 265.3
- MDL Number:
- MFCD00077650
- MOL File:
- 22862-76-6.mol
- MSDS File:
- SDS
| Melting point | 140-141 C |
|---|---|
| Boiling point | 408.52°C (rough estimate) |
| alpha | D23 -30° (methanol) |
| Density | 1.1356 (rough estimate) |
| refractive index | 1.5230 (estimate) |
| Flash point | 87℃ |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | methanol: 20 mg/mL, clear, colorless to faintly yellow |
| pka | 7.9(at 25℃) |
| form | solid |
| color | white |
| Water Solubility | Soluble in water at 2 mg/ml, in DMSO at 20mg/ml, and in methanol at 20mg/ml |
| λmax | 283nm(EtOH)(lit.) |
| Merck | 14,670 |
| BRN | 20705 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | YKJYKKNCCRKFSL-RDBSUJKOSA-N |
| EWG's Food Scores | 1 |
| FDA UNII | 6C74YM2NGI |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 25-36/37/38-20/21/22 | |||||||||
| Safety Statements | 45-36-26 | |||||||||
| RIDADR | UN 3462 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BZ9800000 | |||||||||
| F | 3-10 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29419090 | |||||||||
| Toxicity | LD50 orl-rat: 72 mg/kg ANTCAO 5,490,55 | |||||||||
| NFPA 704 |
|
ANISOMYCIN price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A9789 | Anisomycin from Streptomyces griseolus ≥98% (HPLC), solid | 22862-76-6 | 5mg | $56.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | A5862 | Anisomycin, Ready Made Solution from Streptomyces griseolus | 22862-76-6 | 0.5ml | $85.9 | 2024-03-01 | Buy |
| TCI Chemical | A2613 | Anisomycin >97.0%(GC) | 22862-76-6 | 25mg | $149 | 2024-03-01 | Buy |
| TCI Chemical | A2613 | Anisomycin >97.0%(GC) | 22862-76-6 | 100mg | $437 | 2024-03-01 | Buy |
| Alfa Aesar | J67498 | Anisomycin, 10 mg/ml in DMSO, sterile-filtered | 22862-76-6 | 1ml | $204.65 | 2024-03-01 | Buy |
ANISOMYCIN Chemical Properties,Uses,Production
Description
Anisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable.
Chemical Properties
Crystalline
Uses
It is applied as an antiparasitic agent and antineoplastic agent. It acts as a protein synthesis inhibitor (blocks translation), potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. It also scts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD). Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK).
Uses
Anisomycin is a phenylmethylenepyrrolidine first isolated from Streptomyces griseolus in 1954 as an antiprotozoan with antifungal activity. Anisomycin is an inhibitor of protein synthesis by binding to the 60S ribosomal subunit. Interestingly, anisomycin has found use for the induction of amnesia in animal models. More recently, anisomycin has been demonstrated to induce apoptosis, to be a selective signalling agonist, to activate mitogen-activated protein (MAP) kinases and to be immunomodulatory via its action on T cells.
Definition
ChEBI: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Biological Activity
Protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).
Biochem/physiol Actions
Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.
Safety Profile
Poison by ingestion,intraperitoneal, subcutaneous, and intravenous routes.When heated to decomposition it emits toxic fumes ofNOx.
storage
+4°C
References
1) Hazzalin?et al. (1998),?Anisomycin Selectively Desensitizes Signalling Components Involved in Stress Kinase Activation and fos and jun Induction; Mol. Cell. Bio.,?8?1844 2) Mawji?et al. (2007),?A Chemical Screen Identifies Anisomycin as an Anoikis Sensitizer That Functions by Decreasing FLIP Protein Synthesis; Cancer Res.,?67?8307
ANISOMYCIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3783 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 | wendy@huidabiotech.com | CHINA | 87 | 58 |
View Lastest Price from ANISOMYCIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-11-27 | ANISOMYCIN
22862-76-6
|
US $8000.00 / KG | 100g | 99.99% | 5ton/Month | Qiuxian Baitai New Material Co., LTD | |
 |
2021-06-24 | ANISOMYCIN USP/EP/BP
22862-76-6
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-05-10 | Anisomycin
22862-76-6
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- ANISOMYCIN
22862-76-6
- US $8000.00 / KG
- 99.99%
- Qiuxian Baitai New Material Co., LTD
-
- ANISOMYCIN USP/EP/BP
22862-76-6
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Anisomycin
22862-76-6
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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