6-Hydroxypurine
- CAS No.
- 68-94-0
- Chemical Name:
- 6-Hydroxypurine
- Synonyms
- HYPOXANTHINE;9H-PURIN-6-OL;Hypoxanthine-d4;Hypoxanthine,99%;Hypoxanthine, 99.5%;3,7-dihydropurin-6-one;1,7-DIHYDRO-6H-PURIN-6-ONE;Azathioprine EP Impurity F;6H-Purin-6-one, 1,7-dihydro-;6H-Purin-6-one, 1,9-dihydro-
- CBNumber:
- CB5378579
- Molecular Formula:
- C5H4N4O
- Molecular Weight:
- 136.11
- MDL Number:
- MFCD00005725
- MOL File:
- 68-94-0.mol
- MSDS File:
- SDS
| Melting point | >300 °C (lit.) |
|---|---|
| Boiling point | 250.36°C (rough estimate) |
| Density | 1.4295 (rough estimate) |
| refractive index | 1.8500 (estimate) |
| storage temp. | 2-8°C |
| solubility | 1 M NaOH: 25 mg/mL |
| form | powder |
| pka | 8.7(at 25℃) |
| color | Colorless to yellow to brown, darken on storage with no loss of purity |
| Odor | Odorless |
| Water Solubility | practically insoluble |
| Merck | 14,4869 |
| BRN | 5811 |
| InChIKey | FDGQSTZJBFJUBT-UHFFFAOYSA-N |
| LogP | -0.910 (est) |
| CAS DataBase Reference | 68-94-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 2TN51YD919 |
| NIST Chemistry Reference | Hypoxanthine(68-94-0) |
| EPA Substance Registry System | Hypoxanthine (68-94-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264b-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362+P364-P403+P233-P501c | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-22-40 | |||||||||
| Safety Statements | 22-24/25-37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UP0791000 | |||||||||
| Hazard Note | Harmful | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29335990 | |||||||||
| Toxicity | LD50 intraperitoneal in mouse: 750mg/kg | |||||||||
| NFPA 704 |
|
6-Hydroxypurine price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0002147 | Mercaptopurine impurity A CRS, European Pharmacopoeia (EP) Reference Standard | 68-94-0 | Y0002147 | $156 | 2024-03-01 | Buy |
| Sigma-Aldrich | 4010CBC | Hypoxanthine - CAS 68-94-0 - Calbiochem Xanthine oxidase substrate. | 68-94-0 | 25g | $97.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1191226 | Didanosine Related Compound A United States Pharmacopeia (USP) Reference Standard | 68-94-0 | 25mg | $1490 | 2024-03-01 | Buy |
| TCI Chemical | H0311 | Hypoxanthine >98.0%(HPLC)(E) | 68-94-0 | 5g | $25 | 2024-03-01 | Buy |
| TCI Chemical | H0311 | Hypoxanthine >98.0%(HPLC)(E) | 68-94-0 | 25g | $70 | 2024-03-01 | Buy |
6-Hydroxypurine Chemical Properties,Uses,Production
Description
Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid. It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia. Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.
Chemical Properties
White to off-white powder
Uses
Hypoxanthine, is used as a marker for energy perturbation in hypoxia/ ischemia. The compound has been used in studies as in indicator, along with uric acid and allantoin , of in vivo free radical reactions. It has been also used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol ? (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus. It is also used as a pharmaceutical intermediate.
Uses
Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.
Uses
A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals
Definition
ChEBI: A purine nucleobase that consists of purine bearing an oxo substituent at position 6.
General Description
Hypoxanthine (6-hydroxypurine), a purine derivative is a naturally occurring compound. It is the deaminated form of adenine and a breakdown product of adenosine monophosphate (AMP).
Biochem/physiol Actions
Hypoxanthine?is capable of stimulating cell death. It can also induce reactive oxygen species (ROS). It results in endothelial dysfunction via apoptosis, stimulated by oxidative stress.
Safety Profile
Moderately toxic by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of Nox
Purification Methods
Crystallise it from hot water and dry it at 105o. [Beilstein 26 II 252, 26 III/IV 2081.]
6-Hydroxypurine Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 994 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 298 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
View Lastest Price from 6-Hydroxypurine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-08 | 6-Hydroxypurine
68-94-0
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 2000tons | airuikechemical co., ltd. | |
 |
2024-03-16 | 6-Hydroxypurine
68-94-0
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | |
 |
2023-09-01 | 6-Hydroxypurine
68-94-0
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- 6-Hydroxypurine
68-94-0
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.
-
- 6-Hydroxypurine
68-94-0
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
-
- 6-Hydroxypurine
68-94-0
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
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