15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE
- CAS No.
- 2623-22-5
- Chemical Name:
- 15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE
- Synonyms
- 15-mas;NSC-267030;deacetylanguidin;Desacetylanguidine;15-ACETOXYSCIRPENOL;monoacetoxyscirpenol;15-ACETOXYSCIRPENDIOL;15-MONOACETYLSCIRPENOL;15-MONOACETOXYSCIRPENOL;12,13-Epoxytrichothec-9-ene-3α,4β,15-triol 15-acetate
- CBNumber:
- CB5379697
- Molecular Formula:
- C17H24O6
- Molecular Weight:
- 324.37
- MDL Number:
- MFCD32205816
- MOL File:
- 2623-22-5.mol
- MSDS File:
- SDS
Melting point | 170-172 °C |
---|---|
Boiling point | 465.5±45.0 °C(Predicted) |
Density | 1.34±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | ≤10mg/ml in methanol;10mg/ml in dichloromethane |
form | powder |
pka | 13.72±0.70(Predicted) |
color | White to off-white |
FDA UNII | Z9XD0SRM7U |
15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 11431 | 15-acetoxy Scirpenol ≥98% | 2623-22-5 | 1mg | $242 | 2024-03-01 | Buy |
Cayman Chemical | 11431 | 15-acetoxy Scirpenol ≥98% | 2623-22-5 | 5mg | $965 | 2024-03-01 | Buy |
Usbiological | 412029 | 15-Acetoxyscirpenol | 2623-22-5 | 1mg | $885 | 2021-12-16 | Buy |
TRC | A164293 | 15-Acetoxyscirpenol | 2623-22-5 | 10mg | $4070 | 2021-12-16 | Buy |
ApexBio Technology | C4698 | 15-acetoxyScirpenol | 2623-22-5 | 5mg | $1104 | 2021-12-16 | Buy |
15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Chemical Properties,Uses,Production
Chemical Properties
Solid
Uses
15-Acetoxyscirpenol is a trichothecene mycotoxin and an apoptosis inducer.
Hazard
A poison by ingestion. A mild skin irritant.
Biological Activity
15-acetoxy scirpenol is a trichothecene mycotoxin which is produced predominantly by members of the fusarium genus [1]. 15-acetoxy scirpenol could induce apoptotic cell death in human jurkat t cells. mycotoxins of scirpenol belong to the trichothecene family which is mainly produced by the fungal species of the genus fusarium. acetoxylated scirpenol has very high toxicities in animals and humans. 15-acetoxy scirpenol exhibited cytotoxicity at a lower concentration (25 ng/ml). the 50% inhibitory concentration (ic50) values of 15-acetoxy scirpenol was 16.1 ng/ml [2]. in the jurkat t cells treated with 50 ng/ml of 15-acetoxyscirpenol (15-mas), the populations of externalized ps-positive and pi-negative cells were 32.0% [2].
References
[1] peraica m, radic b, lucic a, et al. toxic effects of mycotoxins in humans[j]. bulletin of the world health organization, 1999, 77(9): 754-766.
[2] lee d h, park t, kim h w. induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving parp in jurkat t cells through treatment with acetoxyscirpenol mycotoxins[j]. biological and pharmaceutical bulletin, 2006, 29(4): 648-654.
15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Preparation Products And Raw materials
15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21666 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10991 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | market@aladdin-e.com | China | 25009 | 65 |
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