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Testosterone

Chemical Properties Indications and Uses Pharmacokinetics Application in Particular Diseases
Testosterone
Testosterone structure
CAS No.
58-22-0
Chemical Name:
Testosterone
Synonyms
Testim;testex;oreton;Dofsol;Teslen;AA 2500;CP 601B;Relibra;Tostrex;Viatrel
CBNumber:
CB5380541
Molecular Formula:
C19H28O2
Formula Weight:
288.42
MOL File:
58-22-0.mol

Testosterone Properties

Melting point:
152-156 °C
alpha 
101 º (c=1, dioxane 25 ºC)
Boiling point:
370.65°C (rough estimate)
Density 
1.0484 (rough estimate)
refractive index 
1.4709 (estimate)
Flash point:
5 °C
storage temp. 
2-8°C
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble18.2 mg/ml
pka
15.06±0.60(Predicted)
form 
powder
Water Solubility 
22.79mg/L(20 ºC)
Merck 
13,9255
BRN 
1915399
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
MUMGGOZAMZWBJJ-DYKIIFRCSA-N
CAS DataBase Reference
58-22-0(CAS DataBase Reference)
FDA 21 CFR
556.710
EWG's Food Scores
2-5
NCI Dictionary of Cancer Terms
testosterone
FDA UNII
3XMK78S47O
NIST Chemistry Reference
Testosterone(58-22-0)
EPA Substance Registry System
Testosterone (58-22-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08,GHS09,GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H302+H312+H332-H319-H302-H351-H360FD-H400
Precautionary statements  P210-P261-P280-P305+P351+P338-P370+P378-P403+P235-P201-P301+P312+P330-P308+P313
Hazard Codes  T,Xn,F
Risk Statements  60-61-11-19-20-40-63-45-36-20/21/22-38
Safety Statements  53-45-24/25-36/37-26-16
RIDADR  UN 2252 3/PG 2
WGK Germany  3
RTECS  XA3030000
HS Code  29372900
Toxicity LD50 oral in mammal (species unspecified): > 5gm/kg

Testosterone price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T-037 Testosterone solution 1.0mg/mL in acetonitrile, ampule of 1mL, certified reference material 58-22-0 037-1ml $37.9 2019-12-02 Buy
Sigma-Aldrich 46923 Testosterone VETRANAL 58-22-0 250mg-r $434 2019-12-02 Buy
Cayman Chemical 15645 Testosterone ≥98% 58-22-0 1g $39 2020-06-24 Buy
Sigma-Aldrich T1500 Testosterone ≥98% 58-22-0 1g $54.1 2019-12-02 Buy
Sigma-Aldrich T5411 Testosterone solution 1.0mg/mL in 1,2-dimethoxyethane, drug standard 1ml $72 2019-12-02 Buy

Testosterone Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder with no aroma. Its melting point is 155℃, specific rotary power is [α]24D+109° (4%, ethanol), and its ethanol solution has the greatest absorbance at a wavelength of 240nm. It is easily soluble in ethanol (1:5), soluble in ether (1:100), and insoluble in water. LD50 (Large mice, venal transfusion) 326mg/kg. Studies show that it has latent carcinogenic effects on test animals.

Indications and Uses

Testosterone is the main natural male sex hormone in mammals and is a steroid hormone with 19 carbon atoms. It is the main male sex hormone secreted by the testes, and it is also the most active male sex hormone. It promotes humans’ and animals’ sex organ and secondary sex characteristic development, sperm maturation, and protein metabolism for muscle strengthening. Testosterone controls the growth and development of male sex organs and male secondary sex characteristics. It is mainly used in replacement therapy for eunuchism, treatment for male menopause syndrome, and treatment for impotence, and it is also used in biochemical research.

Pharmacokinetics

Testosterone can bind non-specifically with plasma albumins in blood, and it can also bind with plasma sex hormone binding globulins. It can be converted into estradiol and estrone in peripheral tissue. Testosterone is mostly degraded in the liver, where its A-ring is restored, and it is converted into 17- ketosteroid under the effects of 17β-Hydroxysteroid dehydrogenase. Along with androsterone, epiandrosterone, and etiocholanlone, it is combined with glucuronic acid or sulfate and excreted in urine. Most metabolites in urine that are excreted by binding to glucuronic acid belong to 17-ketosteroids.

Application in Particular Diseases

In Osteoporosis:

Chemical Properties

white crystalline odourless solid

Uses

Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty.

Uses

androgen, antineoplastic

Uses

Testosterone, Principal hormone of the testes, produced by the interstitial cells. Major circulating androgen; converted by 5α-reductase in androgen-dependent target tissues to 5α-dehydrotestosterone which is required for normal male sexual differentiation. Also converted by aromatization to Estradiol. Testerone is a controlled substance (anabolic steroid). Androgen.

Uses

Rivastigmine metabolite

Uses

Secreted by the testis and is converted to dihydrotestosterone in the target tissue where is appears to mediate many of the biological actions of testosterone. CONTROLLED SUBSTANC

Definition

ChEBI: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-41C-5..

General Description

Testosterone, 17β-hydroxyandrost-4-en-3-one, is a naturally occurring androgen in men. Inwomen, it mainly serves as a biosynthetic precursor to estradiolbut also has other hormonal effects. It is rapidly metabolizedto relatively inactive 17-ones, however,preventing significant oral activity. Testosterone is availablein a transdermal delivery system (patch), a gel formulation, abuccal system, and as implantable pellets.

Hazard

A confirmed carcinogen.

Health Hazard

Controls secondary male sex characteristics Maintains functional competence of male reproductive ducts and glands
Increases protein anabolism; maintains spermatogenesis; inhibits follotropin
Increases male sex behavior; increases closure of epiphyseal plates

Biological Activity

Endogenous androgen receptor agonist.

Safety Profile

Confirmed carcinogen with experimental neoplastigenic and teratogenic data. Poison by intraperitoneal route. Human teratogenic effects by unspecified route: developmental abnormalities of the urogenital system. Experimental reproductive effects. Human mutation data reported. Workers engaged in manufacture and packagmg have shown effects from this hormone, e.g., enlargement of the breasts in male workers. A promoter. When heated to decomposition it emits acrid smoke and irritating fumes. Used as a drug for the treatment of hypogonadism and metastatic breast cancer.

Purification Methods

Crystallise testosterone from aqueous acetone, hexane or isoPrOH. The long needles that separated from EtOH/AcOH were used for X-ray crystallography [Roberts et al. J Chem Soc Perkin Trans II 1978 1973.] The acetate [1045-69-8] crystallises from MeOH or aqueous Me2CO, with m 140-141o and [] D 20 +87.8o (c 1, EtOH). [Ruzicka et al. Helv Chim Acta 18 1478 1935 and 19 99, 842 1936, Beilstein 8 IV 974.]

Testosterone Preparation Products And Raw materials

Raw materials

Preparation Products


Testosterone Suppliers

Global( 306)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Hebei Minshang Biotechnology Co., Ltd
+86-13582176207
2227185311@qq.com CHINA 302 58
Hebei Jimi Trading Co., Ltd.
+86 319 5273535
bestoneforyou@sina.com CHINA 293 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
info@longyupharma.com CHINA 890 58
Taizhou Xinen Biotechnology Co., Ltd.
+8615068633455
singsteroid@163.com CHINA 34 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 229 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3014 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2404 55

View Lastest Price from Testosterone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-05 Testosterone
58-22-0
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2019-11-15 Testosterone
58-22-0
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
2019-10-30 Testosterone
58-22-0
US $0.00 / KG 1g 99.9% 1 ton Hebei shuoxi biotechnology co. LTD

Testosterone Spectrum


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