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Testosterone

Chemical Properties Indications and Uses Pharmacokinetics Application in Particular Diseases
Testosterone
Testosterone structure
CAS No.
58-22-0
Chemical Name:
Testosterone
Synonyms
Testim;Dofsol;Teslen;testex;oreton;AA 2500;CP 601B;Relibra;Tostrex;Viatrel
CBNumber:
CB5380541
Molecular Formula:
C19H28O2
Formula Weight:
288.42
MOL File:
58-22-0.mol

Testosterone Properties

Melting point:
152-156 °C
alpha 
101 º (c=1, dioxane 25 ºC)
Boiling point:
370.65°C (rough estimate)
Density 
1.0484 (rough estimate)
refractive index 
1.4709 (estimate)
Flash point:
5 °C
storage temp. 
2-8°C
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble18.2 mg/ml
form 
powder
Merck 
13,9255
BRN 
1915399
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
MUMGGOZAMZWBJJ-DYKIIFRCSA-N
CAS DataBase Reference
58-22-0(CAS DataBase Reference)
NIST Chemistry Reference
Testosterone(58-22-0)
EPA Substance Registry System
Androst-4-en-3-one, 17-hydroxy-, (17.beta.)-(58-22-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,Xn,F
Risk Statements  60-61-11-19-20-40-63-45-36-20/21/22-38
Safety Statements  53-45-24/25-36/37-26-16
RIDADR  UN 2252 3/PG 2
WGK Germany  3
RTECS  XA3030000
HS Code  29372900
Hazardous Substances Data 58-22-0(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.

Testosterone price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T-037 Testosterone solution 1.0mg/mL in acetonitrile, ampule of 1mL, certified reference material 58-22-0 037-1ml $37.1 2018-11-20 Buy
Sigma-Aldrich 46923 Testosterone VETRANAL 58-22-0 250mg-r $425 2018-11-22 Buy
Cayman Chemical 15645 Testosterone ≥98% 58-22-0 1g $35 2018-11-13 Buy
Cayman Chemical 15645 Testosterone ≥98% 58-22-0 5g $70 2018-11-13 Buy
Sigma-Aldrich T5411 Testosterone solution 1.0mg/mL in 1,2-dimethoxyethane, drug standard 1ml $70.5 2018-11-20 Buy

Testosterone Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder with no aroma. Its melting point is 155℃, specific rotary power is [α]24D+109° (4%, ethanol), and its ethanol solution has the greatest absorbance at a wavelength of 240nm. It is easily soluble in ethanol (1:5), soluble in ether (1:100), and insoluble in water. LD50 (Large mice, venal transfusion) 326mg/kg. Studies show that it has latent carcinogenic effects on test animals.

Indications and Uses

Testosterone is the main natural male sex hormone in mammals and is a steroid hormone with 19 carbon atoms. It is the main male sex hormone secreted by the testes, and it is also the most active male sex hormone. It promotes humans’ and animals’ sex organ and secondary sex characteristic development, sperm maturation, and protein metabolism for muscle strengthening. Testosterone controls the growth and development of male sex organs and male secondary sex characteristics. It is mainly used in replacement therapy for eunuchism, treatment for male menopause syndrome, and treatment for impotence, and it is also used in biochemical research.

Pharmacokinetics

Testosterone can bind non-specifically with plasma albumins in blood, and it can also bind with plasma sex hormone binding globulins. It can be converted into estradiol and estrone in peripheral tissue. Testosterone is mostly degraded in the liver, where its A-ring is restored, and it is converted into 17- ketosteroid under the effects of 17β-Hydroxysteroid dehydrogenase. Along with androsterone, epiandrosterone, and etiocholanlone, it is combined with glucuronic acid or sulfate and excreted in urine. Most metabolites in urine that are excreted by binding to glucuronic acid belong to 17-ketosteroids.

Application in Particular Diseases

In Osteoporosis:

Chemical Properties

white crystalline odourless solid

Uses

Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty.

Uses

androgen, antineoplastic

Uses

Testosterone, Principal hormone of the testes, produced by the interstitial cells. Major circulating androgen; converted by 5α-reductase in androgen-dependent target tissues to 5α-dehydrotestosterone which is required for normal male sexual differentiation. Also converted by aromatization to Estradiol. Testerone is a controlled substance (anabolic steroid). Androgen.

Uses

Rivastigmine metabolite

Uses

Secreted by the testis and is converted to dihydrotestosterone in the target tissue where is appears to mediate many of the biological actions of testosterone. CONTROLLED SUBSTANC

Definition

ChEBI: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-41C-5..

General Description

Testosterone, 17β-hydroxyandrost-4-en-3-one, is a naturally occurring androgen in men. Inwomen, it mainly serves as a biosynthetic precursor to estradiolbut also has other hormonal effects. It is rapidly metabolizedto relatively inactive 17-ones, however,preventing significant oral activity. Testosterone is availablein a transdermal delivery system (patch), a gel formulation, abuccal system, and as implantable pellets.

Hazard

A confirmed carcinogen.

Biological Activity

Endogenous androgen receptor agonist.

Safety Profile

Confirmed carcinogen with experimental neoplastigenic and teratogenic data. Poison by intraperitoneal route. Human teratogenic effects by unspecified route: developmental abnormalities of the urogenital system. Experimental reproductive effects. Human mutation data reported. Workers engaged in manufacture and packagmg have shown effects from this hormone, e.g., enlargement of the breasts in male workers. A promoter. When heated to decomposition it emits acrid smoke and irritating fumes. Used as a drug for the treatment of hypogonadism and metastatic breast cancer.

Purification Methods

Crystallise testosterone from aqueous acetone, hexane or isoPrOH. The long needles that separated from EtOH/AcOH were used for X-ray crystallography [Roberts et al. J Chem Soc Perkin Trans II 1978 1973.] The acetate [1045-69-8] crystallises from MeOH or aqueous Me2CO, with m 140-141o and [] D 20 +87.8o (c 1, EtOH). [Ruzicka et al. Helv Chim Acta 18 1478 1935 and 19 99, 842 1936, Beilstein 8 IV 974.]

Testosterone Preparation Products And Raw materials

Raw materials

Preparation Products


Testosterone Suppliers

Global( 281)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 235 55
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 295 58
Dalian Pinmai Biotechnology Co., Ltd
+86-13230167943
pinmai04@dlpinmai.com CHINA 307 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816
86-0311-83975816 grace@hbhuanhao.com CHINA 680 58
Zhenfei Industrial Co. Ltd.
+86 15318988277
sales@zhenfeichem.com CHINA 76 58
Hebei Jimi Trading Co., Ltd.
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admin@hebeijimi.com CHINA 305 58
Hebei Chisure Biotechnology Co., Ltd.
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+8613292893290 Nancy@SpeedGainpharma.com CHINA 590 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 416 50
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58

View Lastest Price from Testosterone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-02 Testosterone
58-22-0
US $10.00 / KG 100g 99% 10tons Hebei Jimi Trading Co., Ltd.
2018-08-20 Testosterone
58-22-0
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-07-26 Testosterone
58-22-0
US $100.00 / KG 1KG 98% 20kg career henan chemical co

Testosterone Spectrum


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