ChemicalBook >> CAS DataBase List >>methyl 3-(4-methylphenylsulfonamido)benzoate
methyl 3-(4-methylphenylsulfonamido)benzoate
- CAS No.
- 173436-66-3
- Chemical Name:
- methyl 3-(4-methylphenylsulfonamido)benzoate
- Synonyms
- MSAB;GSK549;MSAB >=95% (HPLC);methyl 3-(4-methylphenylsulfonamido)benzoate;Methyl 3-(4-Methylbenzenesulfonamido)benzoate;Benzoic acid, 3-[[(4-methylphenyl)sulfonyl]amino]-, methyl ester;anti-tumor,Wnt,inhibit,MSAB,degradation,β-catenin,Inhibitor,Beta catenin,cancer
- CBNumber:
- CB54050666
- Molecular Formula:
- C15H15NO4S
- Molecular Weight:
- 305.35
- MDL Number:
- MFCD00994918
- MOL File:
- 173436-66-3.mol
- MSDS File:
- SDS
Last updated:2023-04-23 13:52:06
methyl 3-(4-methylphenylsulfonamido)benzoate price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1726 | MSAB ≥95% (HPLC) | 173436-66-3 | 5mg | $114 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1726 | MSAB ≥95% (HPLC) | 173436-66-3 | 25mg | $464 | 2024-03-01 | Buy |
| ChemScene | CS-0078728 | MSAB 99.77% | 173436-66-3 | 100mg | $680 | 2021-12-16 | Buy |
| ChemScene | CS-0078728 | MSAB 99.77% | 173436-66-3 | 5mg | $85 | 2021-12-16 | Buy |
| ChemScene | CS-0078728 | MSAB 99.77% | 173436-66-3 | 50mg | $450 | 2021-12-16 | Buy |
methyl 3-(4-methylphenylsulfonamido)benzoate Chemical Properties,Uses,Production
Biochem/physiol Actions
A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth.
methyl 3-(4-methylphenylsulfonamido)benzoate Preparation Products And Raw materials
Raw materials
Preparation Products
methyl 3-(4-methylphenylsulfonamido)benzoate Suppliers
Global( 43)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Alinda Chemical Ltd. | +7 (495) 672-17-08 | sale@alinda.ru | Russia | 68136 | 55 |
| Adamas Reagent, Ltd. | 400-6009262 16621234537 | zhangsn@titansci.com | China | 14113 | 59 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| Career Henan Chemica Co | 58 |
| InvivoChem | 58 |
| TargetMol Chemicals Inc. | 58 |
| LEAPCHEM CO., LTD. | 58 |
| Aladdin Scientific | 58 |
| Alinda Chemical Ltd. | 55 |
| Adamas Reagent, Ltd. | 59 |
| Sigma-Aldrich | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 55 |
methyl 3-(4-methylphenylsulfonamido)benzoate
MSAB
Methyl 3-(4-Methylbenzenesulfonamido)benzoate
GSK549
Benzoic acid, 3-[[(4-methylphenyl)sulfonyl]amino]-, methyl ester
MSAB >=95% (HPLC)
anti-tumor,Wnt,inhibit,MSAB,degradation,β-catenin,Inhibitor,Beta catenin,cancer
173436-66-3