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Trichlormethiazide

Trichlormethiazide Structure
Trichlormethiazide structure
CAS No.
133-67-5
Chemical Name:
Trichlormethiazide
Synonyms
TRICLORMETIAZIDA;TRICHLOROMETHIAZIDE;Naqua;Flurese;Naquival;Metahydrin;Navis;Nydor;Nakva;Natril
CBNumber:
CB5407444
Molecular Formula:
C8H8Cl3N3O4S2
Molecular Weight:
380.66
MDL Number:
MFCD00057315
MOL File:
133-67-5.mol
Last updated:2024-04-01 18:08:31
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Trichlormethiazide Properties

Melting point 248-250℃
Boiling point 631.3±65.0 °C(Predicted)
Density 1.748
refractive index 1.6000 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka pKa 6.9(acetone/H2O) (Uncertain)
color White to Off-White
Merck 14,9624
CAS DataBase Reference 133-67-5(CAS DataBase Reference)
FDA UNII Q58C92TUN0
ATC code C03AA06
EPA Substance Registry System Trichlormethiazide (133-67-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P272-P280-P284-P302+P352-P304+P340+P312
Hazard Codes  Xn
Risk Statements  42/43
Safety Statements  36
WGK Germany  2
RTECS  DK8925000
HS Code  2935904000
Toxicity LD50 orally in rats: >20000 mg/kg (Goldenthal)
NFPA 704
0
1 0

Trichlormethiazide price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1681000 Trichlormethiazide United States Pharmacopeia (USP) Reference Standard 133-67-5 200mg $358 2024-03-01 Buy
TCI Chemical T1318 Trichloromethiazide >99.0%(T) 133-67-5 10g $204 2024-03-01 Buy
Cayman Chemical 29331 Trichlormethiazide 133-67-5 1g $32 2024-03-01 Buy
Cayman Chemical 29331 Trichlormethiazide 133-67-5 5g $109 2024-03-01 Buy
Cayman Chemical 29331 Trichlormethiazide 133-67-5 10g $169 2024-03-01 Buy
Product number Packaging Price Buy
1681000 200mg $358 Buy
T1318 10g $204 Buy
29331 1g $32 Buy
29331 5g $109 Buy
29331 10g $169 Buy

Trichlormethiazide Chemical Properties,Uses,Production

Chemical Properties

Trichlormethiazide occurs as a white or practically white, crystalline powder and may have a slight characteristic odor.

Originator

Naqua,Schering,US,1960

Uses

diuretic, antihypertensive

Uses

Trichlormethiazide, is a diuretic, having similar properties as Hydrochlorothiazide (H714560). It is used for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.

Uses

Trichlormethiazide is a diuretic and anti-hypertensive agent from the benzothiadiazide class which is used in veterinary medicine in cattle, sheep, goats, pigs and horses, at the following therapeutic regimen: a single intramuscular dose of 0.4 mg/kg bw followed by two oral doses of 0.8 mg/kg bw given 12 and 36 hours after the first administration.
Trichlormethiazide is also used in humans in the United States as a diuretic and anti-hypertensive substance but not in the European Union. The usual dose is 2 to 4 mg twice a day (i.e. approximately 0.033 to 0.066 mg/kg bw/day).

Definition

ChEBI: Trichlormethiazide is a benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a sulfonamide antibiotic.

Manufacturing Process

A mixture of 5.7 grams (0.02 mol) of 5-chloro-2,4-disulfamylaniline and 4.9 grams (0.04 mol) of dichloroacetaldehyde in 25 ml of dimethyl formamide was heated at the boiling temperature and under reflux for 30 minutes. The reaction mixture was thereafter poured into a mixture of ice and water to precipitate the desired 6-chloro-7-sulfamyl-3-dichloromethyl-3,4-dihydro- 1,2,4-benzothiadiazine-1,1-dioxide as a crystalline solid melting at 250° to 270°C with decomposition.

Therapeutic Function

Diuretic

Trichlormethiazide Preparation Products And Raw materials

Raw materials

Isothiazolinones DICHLOROACETALDEHYDE 4-Amino-6-chlorobenzene-1,3-disulfonamide

Preparation Products

Trichlormethiazide Suppliers

Global( 178)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
Suzhou Sanyi Polymer Chemical Technology Co., Ltd. 		+8615571922873 15571922873@163.com China 106 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 994 58
Shaanxi Franta Biotechnology Co., Ltd 		+86-13082019107 +86-13082019107 admin@flanderff.com China 229 58
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9352 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Wuhan Boyuan Import & Export Co., LTD 		+8615175982296 Mike@whby-chem.com China 974 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Supplier Advantage
Hebei Yanxi Chemical Co., Ltd. 		58
Suzhou Sanyi Polymer Chemical Technology Co., Ltd. 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Anhui Ruihan Technology Co., Ltd 		58
Shaanxi Franta Biotechnology Co., Ltd 		58
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Wuhan Boyuan Import & Export Co., LTD 		58
Hubei Jusheng Technology Co.,Ltd. 		58

View Lastest Price from Trichlormethiazide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Trichlormethiazide pictures 2024-04-15 Trichlormethiazide
133-67-5
 US $20.00 / kg 1kg 99 20 ton Suzhou Sanyi Polymer Chemical Technology Co., Ltd.
Trichlormethiazide pictures 2024-04-02 Trichlormethiazide
133-67-5
 US $20.00 / kg 1kg 99 1000kg Shaanxi Franta Biotechnology Co., Ltd
Trichlormethiazide pictures 2024-03-29 Trichlormethiazide
133-67-5
 US $20.00 / kg 1kg 99 1000kg Shaanxi Franta Biotechnology Co., Ltd
  • Trichlormethiazide pictures
  • Trichlormethiazide
    133-67-5
  • US $20.00 / kg
  • 99
  • Suzhou Sanyi Polymer Chemical Technology Co., Ltd.

Trichlormethiazide Spectrum

Trichlormethiazide(133-67-5)MSTrichlormethiazide(133-67-5)1HNMRTrichlormethiazide(133-67-5)13CNMRTrichlormethiazide(133-67-5)IR1Trichlormethiazide(133-67-5)IR2

133-67-5(Trichlormethiazide)Related Search:

Sucralose Methotrexate SPERMINE TETRAHYDROCHLORIDE 1-(5-Amino-4-bromo-2-chloro-phenyl)-ethanone Zinc stearate
4-Amino-6-chlorobenzene-1,3-disulfonamide CLOFENAMIDE Chlorothiazide Tetracycline hydrochloride 2-Aminobenzenesulfonamide
4-Chlorobenzenesulfonamide 2-AMINO-4-CHLOROTHIOPHENOL 2-AMINO-N-METHYLBENZENESULFONAMIDE 5-CHLORO-2-MERCAPTOANILINE HYDROCHLORIDE o-Chlorobenzenesulfonamide
Hydrochlorothiazide Trichlormethiazide 4-Chloro-N-methylbenzenesulphonamide

1of4

6-CHLORO-3-DICHLOROMETHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE 6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamid 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-thiadiazine-7-sulfonamide1,1-dioxide 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide 6-chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide 6-chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio Achletin Anistadin Aponorin Carvacron Chlopolidine Ciba 7057-Su ciba7057-su component of Metatensin component of Naquival Cretonin Diu-Hydrin Diurazida Diurese Diuroral Trichlormethiazid Trichloromethiadiazide Triclordiuride Triclormetiazide Triflumen 3-Dichlormethylhydrochlorothiazide TRICHLORMETHIAZIDE,USP 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide (6CI, 8CI, 9CI) 6-Chloro-3-dichloromethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide NSC 61560 Salirom 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide, (-)- (9CI) Natril Navis Nydor Pluvex 6-chloro-3-(dichloromethyl)-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide Trichlormethiazide (200 mg) TRICHLORMETHIAZIDE 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(dichloromethyl)-3,4-dihydr 3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide 3-dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide 3-dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-d 3-dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio 3-dichloromethylhydrochlorothiazide 6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonam e1,1-dioxide Esmarin Eurinol Fluitran Flutra Gangesol Hydrotrichlorothiazide ide1,1-dioxide