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Trichlormethiazide

Trichlormethiazide
Trichlormethiazide structure
CAS No.
133-67-5
Chemical Name:
Trichlormethiazide
Synonyms
Navis;Nydor;Nakva;Naqua;Natril;Pluvex;Flutra;Diurese;Salirom;Esmarin
CBNumber:
CB5407444
Molecular Formula:
C8H8Cl3N3O4S2
Formula Weight:
380.66
MOL File:
133-67-5.mol

Trichlormethiazide Properties

Melting point:
248-250℃
Boiling point:
631.3±65.0 °C(Predicted)
Density 
1.748
refractive index 
1.6000 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
pKa 6.9(acetone/H2O) (Uncertain)
Merck 
14,9624
CAS DataBase Reference
133-67-5(CAS DataBase Reference)
FDA UNII
Q58C92TUN0
EPA Substance Registry System
Trichlormethiazide (133-67-5)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P280-P284-P304+P340-P342+P311
Hazard Codes  Xn
Risk Statements  42/43
Safety Statements  36
WGK Germany  2
RTECS  DK8925000
HS Code  2935904000
Toxicity LD50 orally in rats: >20000 mg/kg (Goldenthal)

Trichlormethiazide price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T1016 Trichlormethiazide ≥98% 133-67-5 1g $48.5 2021-03-22 Buy
Sigma-Aldrich 1681000 Trichlormethiazide United States Pharmacopeia (USP) Reference Standard 133-67-5 200mg $350 2021-03-22 Buy
TCI Chemical T1318 Trichloromethiazide >99.0%(T) 133-67-5 10g $157 2021-03-22 Buy
Cayman Chemical 29331 Trichlormethiazide 133-67-5 1g $25 2021-03-22 Buy
Cayman Chemical 29331 Trichlormethiazide 133-67-5 5g $88 2021-03-22 Buy

Trichlormethiazide Chemical Properties,Uses,Production

Chemical Properties

Trichlormethiazide occurs as a white or practically white, crystalline powder and may have a slight characteristic odor.

Originator

Naqua,Schering,US,1960

Uses

diuretic, antihypertensive

Uses

Trichlormethiazide is a diuretic and anti-hypertensive agent from the benzothiadiazide class which is used in veterinary medicine in cattle, sheep, goats, pigs and horses, at the following therapeutic regimen: a single intramuscular dose of 0.4 mg/kg bw followed by two oral doses of 0.8 mg/kg bw given 12 and 36 hours after the first administration.
Trichlormethiazide is also used in humans in the United States as a diuretic and anti-hypertensive substance but not in the European Union. The usual dose is 2 to 4 mg twice a day (i.e. approximately 0.033 to 0.066 mg/kg bw/day).

Manufacturing Process

A mixture of 5.7 grams (0.02 mol) of 5-chloro-2,4-disulfamylaniline and 4.9 grams (0.04 mol) of dichloroacetaldehyde in 25 ml of dimethyl formamide was heated at the boiling temperature and under reflux for 30 minutes. The reaction mixture was thereafter poured into a mixture of ice and water to precipitate the desired 6-chloro-7-sulfamyl-3-dichloromethyl-3,4-dihydro- 1,2,4-benzothiadiazine-1,1-dioxide as a crystalline solid melting at 250° to 270°C with decomposition.

Therapeutic Function

Diuretic

Trichlormethiazide Preparation Products And Raw materials

Raw materials

Preparation Products


Trichlormethiazide Suppliers

Global( 141)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Wuhan Monad Medicine Tech Co.,LTD
18771942761 02768782018
sales01@whmonad.com CHINA 1000 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26734 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29959 58
HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
+8619933070948
claire@hbyingong.com China 408 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58

View Lastest Price from Trichlormethiazide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-28 Trichlormethiazide
133-67-5
US $30.00 / KG 1KG 99.9% 1000kg/month Shanxi Lianxu New Material Co., LTD
2021-08-31 Trichlormethiazide
133-67-5
US $10.00 / KG 1KG 99.99% 20 tons/month Wuhan Monad Medicine Tech Co.,LTD
2021-08-23 Trichlormethiazide
133-67-5
US $8.00 / KG 1KG 99% 20TONS Wuhan Shuokang Biological Technology Co.,Ltd

Trichlormethiazide Spectrum


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