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Methylene-bis(4-cyclohexylisocyanate)

Methylene-bis(4-cyclohexylisocyanate)
Methylene-bis(4-cyclohexylisocyanate) structure
CAS No.
5124-30-1
Chemical Name:
Methylene-bis(4-cyclohexylisocyanate)
Synonyms
smdi;picm;rmdi;dmdi;cp99173;hylenew;4,4'-HMDI;reducedmdi;Dicyclohex;HMDI 99.5%
CBNumber:
CB5412149
Molecular Formula:
C15H22N2O2
Formula Weight:
262.35
MOL File:
5124-30-1.mol

Methylene-bis(4-cyclohexylisocyanate) Properties

Melting point:
25°C
Boiling point:
168 °C / 1.5mmHg
Density 
1.066 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.497(lit.)
Flash point:
>230 °F
form 
Liquid
color 
Clear colorless
Water Solubility 
Insoluble/Reactive
BRN 
2217800
Exposure limits
TLV-TWA 0.0535 mg/m3 (0.005 ppm) (ACGIH).
CAS DataBase Reference
5124-30-1(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances
4,4'-METHYLENEBIS(CYCLOHEXYL ISOCYANATE)
FDA 21 CFR
177.1680
EWG's Food Scores
3
FDA UNII
4CT385M7K2
NIST Chemistry Reference
Cyclohexane, 1,1'-methylenebis[4-isocyanato-(5124-30-1)
EPA Substance Registry System
1,1-Methylene bis(4-isocyanatocyclohexane) (5124-30-1)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS08,GHS07,GHS09
Signal word  Danger
Hazard statements  H330-H370-H410-H315-H317-H319-H331-H334-H335
Precautionary statements  P280a-P305+P351+P338-P501a-P260-P264-P270-P271-P272-P273-P302+P352+P333+P313+P363-P304+P340+P310-P305+P351+P338+P337+P313-P307+P311-P391-P405-P501-P261-P280-P284-P304+P340+P312-P342+P311-P403+P233
Hazard Codes  T
Risk Statements  23-36/37/38-42/43
Safety Statements  26-28-38-45-1/2
RIDADR  UN 2206 6.1/PG 2
WGK Germany  1
RTECS  NQ9250000
TSCA  Yes
HazardClass  6.1
PackingGroup  III

Methylene-bis(4-cyclohexylisocyanate) price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 33490 HMDI analyticalstandard 5124-30-1 2 mL $61.4 2021-12-16 Buy
Sigma-Aldrich 388386 4,4′-Methylenebis(cyclohexyl isocyanate), mixture of isomers 90% 5124-30-1 100ml $48.3 2021-12-16 Buy
Sigma-Aldrich 33490 HMDI analytical standard 5124-30-1 2ml-r $59.5 2021-12-16 Buy
TCI Chemical D2380 Dicyclohexylmethane 4,4'-Diisocyanate (mixture of isomers) >90.0%(GC) 5124-30-1 25g $19 2021-12-16 Buy
TCI Chemical D2380 Dicyclohexylmethane 4,4'-Diisocyanate (mixture of isomers) >90.0%(GC) 5124-30-1 100g $27 2021-12-16 Buy

Methylene-bis(4-cyclohexylisocyanate) Chemical Properties,Uses,Production

Description

Methylene bis (4-cyclohexylisocyanate) (HMDI) (CAS No. 5124-30-1) is a clear to pale yellow liquid, which is soluble in acetone water and is incompatible with alcohols, amines, bases, acids, and may slowly polymerize if heated above 50 ℃. HMDI reacts with water and alcohol.

Chemical Properties

Liquid.Soluble in acetone;reacts with water or ethanol.

Chemical Properties

DMDI is a clear, colorless to light-yellow liquid.

Uses

Methylene bis(4-cyclohexylisocyanate) isused to produce urethane foam with colorstability.

Uses

In the manufacture of polymers

Uses

HMDI has excellent light stability and the stability of the six membered ring structure, has excellent weather resistance and excellent mechanical properties of polyurethane material, and is especially suitable for the production of high performance elastic body, a water polyurethane resin and UV resin.

Definition

ChEBI: A diisocyanate consisting of dicyclohexylmethane with two isocyanate groups at the 4- and 4'-positions.

General Description

Clear colorless to light-yellow liquid.

Air & Water Reactions

Reacts with water to form CO2

Reactivity Profile

Isocyanates and thioisocyanates, such as Methylene-bis(4-cyclohexylisocyanate), are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].

Hazard

Strong skin and eye irritant. Respiratorysensitization and lower respiratory tract irritant.

Health Hazard

Studies on test animals indicate that methy-lene bis(4-cyclohexylisocyanate) is highlytoxic by an inhalation route and can causesevere skin reaction. Exposure to 20 ppmfor 5 hours produced irritation of the respiratory tract, tremor, convulsion, congestion oflungs, and edema in rats. The symptoms atlower levels were decreased as to respirationrate and pulmonary irritation.
Contact with the skin can produce severeirritation, erythema, and edema. The oraltoxicity of this compound is very low.
LD50 value, oral (rats): 9900 mg/kg
There is no report of the compound’smutagenicity or carcinogenicity.

Fire Hazard

Flash point data for Methylene-bis(4-cyclohexylisocyanate) are not available. Methylene-bis(4-cyclohexylisocyanate) is probably combustible.

Safety Profile

Poison by inhalation. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx and CN-.

Potential Exposure

A potential danger to those involved in the manufacture of this compound or its use in the production of light-stable, nonyellowing polyurethane resins.

Environmental Fate

HMDI is a synthetic organic chemical which does not occur naturally in the environment. At room temperature, it is a liquid. HMDI hydrolyzes rapidly in water, producing methylene bis(4-cyclohexylamine). The half-life for HMDI is approximately 2 h. Due to its rapid hydrolysis, transport between environmental compartments is unlikely to occur. Because of the rapid hydrolysis, the assessment of the substance is based on the hydrolysis product methylenebis(cyclohexylamine) and not on HMDI. The hydrolysis product was not classified as a PBT (persistent, bioaccumulative, toxic) substance. These data indicate that HMDI is not readily biodegradable. However, due to its rapid hydrolysis, HMDI is neither persistent in the water compartment nor bioaccumulative. The calculated Koc-value indicates that HMDI may strongly adsorb to soil; however, any emission to the terrestrial compartment would be affected by humidity and, therefore, terrestrial accumulation is not expected to occur.

Shipping

UN2206 Isocyanates, toxic, n.o.s. or Isocyanate solutions, toxic, n.o.s., flash point .61C and boiling point ,300C, Hazard Class: 6.1; Labels: 6.1-Poisonous materials., Technical Name Required.

Toxicity evaluation

The toxicological properties of isocyanates are attributed to the –N=C=O group. Skin sensitization with HMDI is thought to be associated with the activation and proliferation of lymphocytes in lymph nodes draining the site of exposure. Analysis of the nature and kinetics of the cytokine production (which regulates lymphocyte production) postexposure to HMDI revealed that both interleukin-1 (IL-1) and IL-6 were induced in a biphasic manner. The ordered and transient pattern of cytokine production that occurs during the afferent phase of contact sensitization suggests that sequential cytokine signals may be involved in regulating the characteristics of the response generated within the draining lymph node.

Incompatibilities

May form explosive mixture with air. Isocyanates are highly flammable and reactive with many compounds, even with themselves. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Reaction with moist air, water or alcohols may form amines and insoluble polyureas and react exothermically, releasing toxic, corrosive or flammable gases, including carbon dioxide; and, at the same time, may generate a violent release of heat increasing the concentration of fumes in the air. Incompatible with amines, aldehydes, alkali metals, ammonia, carboxylic acids, caprolactum, alkaline materials, glycols, ketones, mercaptans, hydrides, organotin catalysts, phenols, strong acids, strong bases, strong reducing agents such as hydrides, urethanes, ureas. Elevated temperatures or contact with acids, bases, tertiary amines, and acylchlorides may cause explosive polymerization. Attacks some plastics, rubber and coatings. Contact with metals may evolve flammable hydrogen gas. May accumulate static electrical charges, and may cause ignition of its vapors. May slowly polymerize if heated above 122F/50C. Contact with metals may evolve flammable hydrogen gas.

Waste Disposal

Methylene bis(4-cyclohexylisocyanate) isdissolved in acetone or any other combustible solvent and burned in a chemicalincinerator equipped with an afterburner andscrubber.

Methylene-bis(4-cyclohexylisocyanate) Preparation Products And Raw materials

Raw materials

Preparation Products


Methylene-bis(4-cyclohexylisocyanate) Suppliers

Global( 116)Suppliers
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View Lastest Price from Methylene-bis(4-cyclohexylisocyanate) manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-10 Methylene-bis(4-cyclohexylisocyanate)
5124-30-1
US $1.00 / KG 1KG 99% 100kg Career Henan Chemical Co

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