Allopregnanolone
- CAS No.
- 516-54-1
- Chemical Name:
- Allopregnanolone
- Synonyms
- Brexanolone;ALLOPREGNANOLONE;Anlotinib Dihydrochloride;(3a)-Allopregnanolone;allotetrahydroprogesterone;3α-hydroxy-5α-pregnan-20-one;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one;5α-P;3α-OH-DHP;3α,5α-THP
- CBNumber:
- CB5418550
- Molecular Formula:
- C21H34O2
- Molecular Weight:
- 318.49
- MDL Number:
- MFCD00003677
- MOL File:
- 516-54-1.mol
| Melting point | 176-178° |
|---|---|
| alpha | D +87.7° (abs alc) |
| Boiling point | 431.2±18.0 °C(Predicted) |
| Density | 1.053±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | chloroform: 20 mg/mL, clear, colorless |
| pka | 15.12±0.70(Predicted) |
| form | White solid |
| color | white |
| Merck | 13,272 |
| BRN | 3211363 |
| Stability | Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChIKey | AURFZBICLPNKBZ-SYBPFIFISA-N |
| CAS DataBase Reference | 516-54-1(CAS DataBase Reference) |
| FDA UNII | S39XZ5QV8Y |
Allopregnanolone price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P8887 | 5α-Pregnan-3α-ol-20-one solid | 516-54-1 | 5mg | $211 | 2024-03-01 | Buy |
| Cayman Chemical | 16930 | Allopregnanolone ≥98% | 516-54-1 | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 16930 | Allopregnanolone ≥98% | 516-54-1 | 5mg | $160 | 2024-03-01 | Buy |
| Sigma-Aldrich | P8887 | 5α-Pregnan-3α-ol-20-one solid | 516-54-1 | 10mg | $254 | 2024-03-01 | Buy |
| Cayman Chemical | 16930 | Allopregnanolone ≥98% | 516-54-1 | 10mg | $239 | 2024-03-01 | Buy |
Allopregnanolone Chemical Properties,Uses,Production
Description
Allopregnanolone is an endogenous inhibitory pregnane neurosteroid that is synthesized from progesterone . It acts as a positive allosteric modulator of GABAA receptors at nM concentrations (exhibiting the greatest potentiation at isoforms containing δ subunits) and of GABAC receptors at μM concentrations. Allopregnanolone displays effects similar to other GABAA receptor potentiators such as benzodiazepines, including potent anticonvulsant, anxiolytic, and sedative activity.
Uses
(3α)-Allopregnanolone acts as a GABAA receptor positive allosteric modulator. (3α)-Allopregnanolone is a metabolite of Progesterone (P755900). (3α)-Allopregnanolone is a neuroactive steroid present in the blood and also the brain.
Definition
ChEBI: Brexanolone is a 3-hydroxy-5alpha-pregnan-20-one in which the hydroxy group at position 3 has alpha-configuration. It is a metabolite of the sex hormone progesterone and used for the treatment of postpartum depression in women. It has a role as a human metabolite, an antidepressant, a GABA modulator, an intravenous anaesthetic and a sedative.
Biological Activity
GABA A receptor positive allosteric modulator. Neuroactive steroid.
storage
Room temperature
References
1) Belelli and Lambert (2005),?Neurosteroids: endogenous regulators of the GABA(A) receptor; Nat. Rev. Neurosci,,?6?565 2) Reddy?et al. (2010),?Neurosteroids: endogenous role in the human brain and therapeutic potentials; Prog. Brain Res.,?186?113 3) Frieder?et al. (2019),?Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development; CNS Drugs,?33?265 4) Balan?et al.?(2019),?Endogenous Neurosteroid (3α,5α)3-Hydroxypregnan-20-one Inhibits Toll-like-4 Receptor Activation and Proinflammatory Signaling in Macrophages and Brain; Sci. Rep.,?9?1220 5) Chang?et al.?(2019),?Neurosteroid allopregnanolone inhibits glutamate release from rat cerebrocortical nerve terminals; Synapse,?73?e22076 6) Cho?et al.?(2018),?Increased Superoxide Dismutase 2 by Allopregnanolone Ameliorates ROS-Mediated Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus; Neurochem. Res.,?43?1464
Allopregnanolone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | sales@sdperfect.com | China | 294 | 58 |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1100 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Jinan Chenghui-Shuangda Chemical Co.,Ltd | +86-531-58897082 | ericqiao@jnchsd.com | CHINA | 158 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
Related articles
- How to synthesize Brexanolone？
- Developed by Sage Therapeutics, brexanolone was approved by the USFDA as a first-in-class treatment for PPD in adult women.
- Jan 8，2024
View Lastest Price from Allopregnanolone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-28 | Brexanolone
516-54-1
|
US $0.00 / kg | 25kg | 98% | Inquiry | PNP Biotech Co. Ltd | |
 |
2024-03-12 | 5alpha-Pregnan-3alpha-ol-20-one
516-54-1
|
US $0.00 / g | 1g | 98% HPLC | 1kg | shandong perfect biotechnology co.ltd | |
 |
2023-10-16 | ALLOPREGNAN-3ALPHA-OL-20-ONE
516-54-1
|
US $35.00-25.00 / kg | 1kg | 99% | 20 Ton | Hebei Xinsheng New Material Technology Co., LTD. |
-
- Brexanolone
516-54-1
- US $0.00 / kg
- 98%
- PNP Biotech Co. Ltd
-
- 5alpha-Pregnan-3alpha-ol-20-one
516-54-1
- US $0.00 / g
- 98% HPLC
- shandong perfect biotechnology co.ltd
-
- ALLOPREGNAN-3ALPHA-OL-20-ONE
516-54-1
- US $35.00-25.00 / kg
- 99%
- Hebei Xinsheng New Material Technology Co., LTD.
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