Clidinium bromide | 3485-62-9

Clidinium bromide Properties

Melting point	240-241°C
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
color	White to Off-White
CAS DataBase Reference	3485-62-9(CAS DataBase Reference)
FDA UNII	91ZQW5JF1Z

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

Xn

Risk Statements

22

Safety Statements

36

RIDADR

3249

WGK Germany

3

RTECS

VD6125000

HazardClass

6.1(b)

PackingGroup

III

HS Code

2933399090

NFPA 704

	0
2		0

Clidinium bromide price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C0414	Clidinium bromide analytical standard	3485-62-9	1g	$98.1	2024-03-01	Buy
Sigma-Aldrich	1135000	Clidinium bromide United States Pharmacopeia (USP) Reference Standard	3485-62-9	500mg	$436	2024-03-01	Buy
Cayman Chemical	21428	Clidinium (bromide) ≥98%	3485-62-9	500mg	$44	2024-03-01	Buy
Cayman Chemical	21428	Clidinium (bromide) ≥98%	3485-62-9	1g	$73	2024-03-01	Buy
TRC	C576250	Clidinium bromide	3485-62-9	50g	$1580	2021-12-16	Buy

Product number	Packaging	Price	Buy
C0414	1g	$98.1	Buy
1135000	500mg	$436	Buy
21428	500mg	$44	Buy
21428	1g	$73	Buy
C576250	50g	$1580	Buy

Clidinium bromide Chemical Properties,Uses,Production

Description

Clidinium is a gastrointestinal muscarinic receptor antagonist (K_i = 3 nM against [³H]quinuclidinyl benzilate binding in rat colonic enterocytes). Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice. This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.

Chemical Properties

White Crystalline Solid

Originator

Librax,Roche,US,1961

Uses

An anticholinergic. Used as an antispasmodic.

Uses

Clidinium inhibits muscarinic action of acetylcholine on postganglionic parasympathetic effector regions. It is used for treating stomach ulcers.

Definition

ChEBI: The bromide salt of clinidium. It is used for the symptomatic treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.

Manufacturing Process

5.12 g of 1-azabicyclo[2.2.2]-3-octanol were refluxed with a suspension of 0.92 g of finely divided sodium in 50 cc of toluene, until most of the sodium had reacted (about 4 hours). The thus obtained suspension of the white amorphous alcoholate was cooled with ice, and reacted with 10.16 g of diphenylchloroacetyl chloride, which was added in form of a solution in approximately 40 cc of toluene. The mixture was stirred for 1 hour at room temperature. Small amounts of unreacted sodium were destroyed with isopropanol, and 120 cc of 1 N hydrochloric acid were then added, The mixture was refluxed for 1/2 hour, in order to convert the first formed product, diphenylchloroacetic acid ester of 1-azabicyclo[2.2.2]-3-octanol, into the corresponding benzilic acid ester.
The toluene phase was separated and discarded. The aqueous phase, together with a precipitated water- and toluene-insoluble oil, was made alkaline and extracted repeatedly with chloroform. The chloroform solution was concentrated in vacuo. The residue was recrystallized from a mixture of acetone and ether (alternatively, from chloroform and ether), and formed needles melting at 164° to 165°C. It was identified as 3-benziloyloxy-1- azabicyclo[2.2.2]octane.
3-Benziloyloxy-1-azabicyclo[2.2.2]octane methobromide was prepared by adding 20 cc of a 30% solution of methyl bromide in ether to a solution of 2.5 g of 3-benziloyloxy-1-azabicyclo[2.2.2]octane in 20 cc of chloroform. After standing for 3 hours at room temperature and 15 hours at +5°C, a crystalline precipitate had formed. This was filtered off and recrystallized from a mixture of methanol, acetone, and ether; prisms melting at 240° to 241°C.

brand name

Quarzan (Roche).

Therapeutic Function

Anticholinergic, Antiulcer

General Description

Clidinium bromide, 3-hydroxy-1-methylquinuclidinium bromide benzilate (Quarzan),is a white or nearly white, almost odorless, crystalline powderthat is optically inactive. It is soluble in water and alcohol butonly very slightly soluble in ether and benzene.

Clinical Use

This anticholinergic agent is marketed alone and in combinationwith the minor tranquilizer chlordiazepoxide (Librium)in a product known as Librax. The rationale of the combinationfor the treatment of GI complaints is the use of an anxiety-reducing agent together with an anticholinergic agent,based on the recognized contribution of anxiety to the developmentof the diseased condition. It is suggested for pepticulcer, hyperchlorhydria, ulcerative or spastic colon, anxietystates with GI manifestations, nervous stomach, irritable orspastic colon, and others. Clidinium bromide is contraindicatedin glaucoma and other conditions that may be aggravatedby the parasympatholytic action, such as prostatic hypertrophyin elderly men, which could lead to urinary retention.

Synthesis

Clidinium, 3-benzyloyloxy-1-methylcynuclidinium bromide (14.1.19), is synthesized by reacting 3-hydroxycynuclidine (14.1.17) with the of benzilic acid chloride producing the ester (14.1.18), which if further alkylated at the nitrogen atom by methylbromide, giving clidinium (14.1.19) [16].

Synthesis_3485-62-9

Clidinium bromide Preparation Products And Raw materials

Raw materials

Methyl bromide 2-CHLORO-2,2-DIPHENYLACETYL CHLORIDE Sodium

Preparation Products

Clidinium bromide Suppliers

Global( 120)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9339	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9427	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Bio-Technology Co., Ltd.	58
Baoji Guokang Healthchem co.,ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Nextpeptide Inc	58

View Lastest Price from Clidinium bromide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-06-15	Clidinium bromide 3485-62-9	US $132.00 / g	1g	98%	10-100kg	Baoji Guokang Bio-Technology Co., Ltd.
2021-07-13	Clidinium bromide 3485-62-9	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09	Clidinium bromide 3485-62-9	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Clidinium bromide
3485-62-9
US $132.00 / g
98%
Baoji Guokang Bio-Technology Co., Ltd.

Clidinium bromide
3485-62-9
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Clidinium bromide
3485-62-9
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

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RO-2-3773 quinuclidinolmethylbromide,benzilate 3-[(Hydroxyphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2,2,2]octane Bromide, Ro-2-3773, Quarzan (1-Methyl-1-azoniabicyclo[2.2.2]octan-8-yl) 2-hydroxy-2,2-diphenylacetate bromide 1-Azoniabicyclo[2.2.2]octane, 3-[(hydroxydiphenylacetyl)oxy]-1-methyl-, bromide 3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane bromide Ro-3773 3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane Clidinium Brimide Clidinium Bromide (500 mg) Clidinium Bromide (2 g) 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-Methyl-1-azabicyclo[2.2.2]octan-1-iuM broMide 1-methyl-3-benzil-oxyloxy-quinuclidiniumbromide 3-((hydroxydiphenylacetyl)oxy)-1-methyl-1-azoniabicyclo(2.2.2)octanbromi CLIDINIUM BROMIDE 3-[(HYDROXYPHENYLACETYL)OXY]-1-METHYL-1-AZONIABICYCLO[2,2,2]OCTANE BROMIDE 3-HYDROXY-1-METHYLQUINUCLIDINIUM BROMIDE BENZILATE 3-(2,2-diphenyl-2-hydroxyethanoyloxy)-quinuclidiniumbromide 3-(benziloyloxy)-1-methylquinuclidiniumbromide benzilicacid,esterwith3-hydroxy-1-methylquinuclidinium quarzanbromide quinuclidinium,3-hydroxy-1-methyl-,bromide,benzilate Clidinium iodide D3 2-hydroxy-2,2-diphenylacetic acid (1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl) ester bromide 3-(2-Hydroxy-2,2-diphenylacetoxy)-1-methylquinuclidin-1-ium bromide Clidinium BromideQ: What is Clidinium Bromide Q: What is the CAS Number of Clidinium Bromide Q: What is the storage condition of Clidinium Bromide Q: What are the applications of Clidinium Bromide Clidinium-D5 bromideQ: What is Clidinium-D5 bromide Q: What is the CAS Number of Clidinium-D5 bromide Clidinium Bromide (1135000) AV 54315 AV54315 AV-54315 QUARZAN Clidinium 3485-62-9 C22H26NO3Br C22H26BO3Rn C22H26BrNO3 Alphabetic Analytical Chromatography Product Catalog Analytical Standards CI - CL QUARZAN Intermediates & Fine Chemicals Pharmaceuticals