ChemicalBook
Chinese Japanese Germany

Cemandil sodium salt

Cemandil sodium salt
Cemandil sodium salt structure
CAS No.
42540-40-9
Chemical Name:
Cemandil sodium salt
Synonyms
Fado;CefaM;Cedol;CeMado;Nafate;mandol;Cefiran;Kefadol;Pavecef;Bergacef
CBNumber:
CB5430833
Molecular Formula:
C19H17N6NaO6S2
Formula Weight:
512.49
MOL File:
42540-40-9.mol

Cemandil sodium salt Properties

Melting point:
190-193°C
storage temp. 
-20?C Freezer, Under Inert Atmosphere
solubility 
Freely soluble in water, sparingly soluble in methanol.
form 
neat
pka
2.6-3.0(at 25℃)
Water Solubility 
Freely soluble in water. Sparingly soluble in methanol
CAS DataBase Reference
42540-40-9(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  36/37/38-42/43
Safety Statements  26-36
WGK Germany  3
RTECS  XI0380000
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P405 Store locked up.

Cemandil sodium salt price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C0682300 Cefamandole nafate European Pharmacopoeia (EP) Reference Standard 42540-40-9 c0682300 $179 2018-11-23 Buy
Sigma-Aldrich 1097400 Cefamandole nafate United States Pharmacopeia (USP) Reference Standard 42540-40-9 250mg $338.1 2018-11-20 Buy
Alfa Aesar J66735 Cefamandole nafate 42540-40-9 5g $154 2018-11-13 Buy
Alfa Aesar J66735 Cefamandole nafate 42540-40-9 10g $270 2018-11-13 Buy
Cayman Chemical 23988 Cefamandole Nafate ≥95% 42540-40-9 500mg $44 2018-11-19 Buy

Cemandil sodium salt Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Cephalosporin antibacterial.

Definition

ChEBI: A cephalosporin prodrug having (R)-O-formylmandelamido and N-methylthiotetrazole side-groups.

brand name

Mandol (Lilly).

Clinical Use

Cefamandole (Mandol) nafate is the formate ester ofcefamandole, a semisynthetic cephalosporin that incorporates D-mandelic acids as the acyl portion and a thiol-containingheterocycle (5-thio-1,2,3,4-tetrazole) in place of the acetoxylfunction on the C-3 methylene carbon atom. Esterification ofthe α-hydroxyl group of the D-mandeloyl function overcomesthe instability of cefamandole in solid-state dosage formsand provides satisfactory concentrations of the parent antibioticin vivo through spontaneous hydrolysis of the ester atneutral to alkaline pH. Cefamandole is the first second-generationcephalosporin to be marketed in the United States.
The D-mandeloyl moiety of cefamandole appears toconfer resistance to a few β-lactamases, since some β-lactamase–producing, Gram-negative bacteria (particularlyEnterobacteriaceae) that show resistance to cefazolin andother first-generation cephalosporins are sensitive tocefamandole. Additionally, it is active against some ampicillin-resistant strains of Neisseria and Haemophilus spp.Although resistance to β-lactamases may be a factor in determiningthe sensitivity of individual bacterial strains tocefamandole, an early study indicated that other factors,such as permeability and intrinsic activity, are frequentlymore important. The L-mandeloyl isomer is significantlyless active than the D-isomer.
Cefamandole nafate is very unstable in solution andhydrolyzes rapidly to release cefamandole and formate.There is no loss of potency, however, when such solutionsare stored for 24 hours at room temperature or up to 96hours when refrigerated. Air oxidation of the released formateto carbon dioxide can cause pressure to build up in theinjection vial.

Cemandil sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products


Cemandil sodium salt Suppliers

Global( 118)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2548 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8430 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 295 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96738 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912
86-027-87531808 sales@chemwish.com China 35926 56
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32492 50

42540-40-9(Cemandil sodium salt)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved