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AUY954

AUY954 Structure
AUY954 structure
CAS No.
820240-77-5
Chemical Name:
AUY954
Synonyms
AUY954;AUY-954 free base;AUY 954 free base,AUY954 free base;N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-β-alanine;β-Alanine, N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-
CBNumber:
CB54666241
Molecular Formula:
C25H20F3NO2S
Molecular Weight:
455.5
MDL Number:
MOL File:
820240-77-5.mol
Last updated:2023-05-21 10:59:17
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AUY954 Properties

Boiling point 646.3±55.0 °C(Predicted)
Density 1.314±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form A crystalline solid
pka 3.62±0.12(Predicted)

AUY954 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 9000548 AUY954 ≥98% 820240-77-5 500μg $68 2024-03-01 Buy
Cayman Chemical 9000548 AUY954 ≥98% 820240-77-5 1mg $121 2024-03-01 Buy
Cayman Chemical 9000548 AUY954 ≥98% 820240-77-5 5mg $370 2024-03-01 Buy
AK Scientific 6228CS 3-[[2-[4-Phenyl-3-(trifluoromethyl)phenyl]-1-benzothiophen-5-yl]methylamino]propanoicacid 820240-77-5 5mg $509 2021-12-16 Buy
Product number Packaging Price Buy
9000548 500μg $68 Buy
9000548 1mg $121 Buy
9000548 5mg $370 Buy
6228CS 5mg $509 Buy

AUY954 Chemical Properties,Uses,Production

Description

AUY954 is an orally bioavailable and selective agonist of the sphingosine-1-phosphate receptor 1 (S1P1; EC50 = 1.2 nM for stimulating GTPγS binding to S1P1 in CHO cells). It is highly selective for the S1P1 receptor with EC50 values of >10,000, 1,210, >1,000, and 340 nM for S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 reduces circulating lymphocytes and prevents rejection of rat heart allografts. In a rat model of experimental autoimmune neuritis, chronic treatment with AUY954 (10 mg/kg), starting on the day of immunization, almost completely prevents peripheral paralysis. In the same model, it also decreases T cell, B cell, and macrophage infiltration and perivascular demyelination in sciatic nerves.

AUY954 Preparation Products And Raw materials

Raw materials

Preparation Products

AUY954 Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7979 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 5586 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
AUY954 β-Alanine, N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]- AUY-954 free base AUY 954 free base,AUY954 free base N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-β-alanine 820240-77-5 C25H20F3NO2S