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Butylparaben

Chemical properties Production method Uses Toxicity Content analysis Usage limit Hazards & Safety Information
Butylparaben
Butylparaben structure
CAS No.
94-26-8
Chemical Name:
Butylparaben
Synonyms
SPF;butoben;solbrolb;Lexgard B;Nipabutyl;Solbrol B;tegoseptb;FEMA 2203;butylbutex;preservalb
CBNumber:
CB5466788
Molecular Formula:
C11H14O3
Formula Weight:
194.23
MOL File:
94-26-8.mol

Butylparaben Properties

Melting point:
67-70 °C(lit.)
Boiling point:
156-157 °C3.5 mm Hg(lit.)
Density 
1.28
refractive index 
1.5115 (estimate)
FEMA 
2203 | BUTYL P-HYDROXY BENZOATE
Flash point:
181℃
storage temp. 
0-6°C
solubility 
Soluble in DMSO, ethyl acetate, methanol.
pka
pKa 8.5 (Uncertain)
form 
Crystalline Powder
color 
White to almost white
Water Solubility 
<0.1 g/100 mL at 17 ºC
Merck 
14,1584
JECFA Number
870
BRN 
1103741
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong alkalies.
InChIKey
QFOHBWFCKVYLES-UHFFFAOYSA-N
CAS DataBase Reference
94-26-8(CAS DataBase Reference)
NIST Chemistry Reference
P-hydroxybenzoic acid, n-butyl ester(94-26-8)
EPA Substance Registry System
Benzoic acid, 4-hydroxy-, butyl ester(94-26-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Risk Statements  36/37/38
Safety Statements  22-24/25-37/39-26
WGK Germany  2
RTECS  DH1980000
TSCA  Yes
Hazardous Substances Data 94-26-8(Hazardous Substances Data)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P501 Dispose of contents/container to..…

Butylparaben price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 54680 Butyl 4-hydroxybenzoate ≥99.0% (GC) 94-26-8 1kg-f $142 2018-11-13 Buy
Sigma-Aldrich 1084000 Butylparaben United States Pharmacopeia (USP) Reference Standard 94-26-8 200mg $399.35 2018-11-13 Buy
TCI Chemical B3771 Butyl 4-Hydroxybenzoate [for Biochemical Research] >99.0%(GC)(T) 94-26-8 5g $22 2018-11-22 Buy
TCI Chemical B3771 Butyl 4-Hydroxybenzoate [for Biochemical Research] >99.0%(GC)(T) 94-26-8 25g $48 2018-11-22 Buy
Alfa Aesar A14043 n-Butyl 4-hydroxybenzoate, 99+% 94-26-8 250g $52 2018-11-13 Buy

Butylparaben Chemical Properties,Uses,Production

Chemical properties

It appears as white crystal powder, having slightly special odor. It is slightly soluble in water, being soluble in alcohol, ether and chloroform.

Production method

It is derived from the esterification between p-hydroxybenzoic acid and butanol. Butanol and p-hydroxybenzoic acid are heated together for being dissolved, slowly added dropwise of sulfuric acid, continue the refluxing for 8h. After cooling, add 4% sodium carbonate solution, separate the water layer, steam out the butanol, let it cool, filter to obtain the crude product, and then carry out ethanol recrystallization (solubility in ethanol: 200g/100ml).
Take sulfuric acid as a catalyst; derive it from the reaction between p-hydroxybenzoic acid and butanol.

Uses

1. Butylparaben can be used for the antibacterial and anticorrosion of drugs, cosmetics and food.
2. As a kind of preservative; Because of the low solubility in water, Butylparaben is usually prepared into ethanol solution, acetic acid solution or sodium hydroxide solution. To improve the solubility, several different esters are often used. For example, three parts of isobutyl, four parts of isopropyl and three parts of butyl are formulated as a co-soluble mixture and the mixture is used as an oil-in-water emulsifier. This preparation is easy to use in soy sauce and other foods, the solubility of butyl ester alone can be increased by 2 to 3 times. For soy sauce, 5% sodium hydroxide solution can be added to the goods of 20% to 25%, and then slowly added to the sauce having been heated to about 80 ℃. Acetic acid solution or ester type emulsifier can also be used. The usage amount of anti-mold soy sauce is 0.05~0.10g/L. Vinegar can be used in acetic acid or sodium hydroxide solution. Soft drinks can be used in the solution of sodium hydroxide, but usually used in combination with benzoic acid and dehydroacetic acid.
3. Used as organic synthesis intermediates; the anti-corrosion additives of medicine, food, cosmetics, film and high-grade products; reagents. Being used as germicide preservative of food is Butylparaben's major application. In the p-hydroxybenzoic acid esters, it can give the strongest anti-corrosion bactericidal effect. Because of its poor water solubility, it is often used with other esters in combination.
4. For preservatives and disinfectants

Toxicity

ADI is subject to postponed decision (FAO/WHO, 2001).
LD50: 16.0 g/kg (mouse, subcutaneous injection).
Mice subjecting to short-term toxicity test have gotten inhibited weight increase. There have been reports regarding to the acute dermatitis for human beings. In the p-hydroxybenzoic acid esters, this product gives the best anti-corrosion effect, but also the largest toxicity.

Content analysis

2g (accurate to 0.1mg) was taken and dried in silica gel for 5h before being transferred to the flask. Add 40 mL of 1mol/L of sodium hydroxide, flush flasks with water. Cover the surface of the dish and apply a small fire to boil 1h before cooling. Add 5 drops of bromothymol blue solution (TS-56), titrate the excess sodium hydroxide with 1 mol/L sulfuric acid, and make the color of the solution consistent with the buffer containing the same indicator (pH 6.5). Carry out a blank test at the same time and make the necessary calibration. 1ml/L sodium hydroxide per milliliter corresponds to the 194.2 mg of this product (C11H14O3).

Usage limit

Japan (1998, calculated on p-hydroxybenzoic acid; the data in parentheses is the amount converted into equivalent amount of this product, g/ kg), soy sauce 0.25 g/L (0.35 g/L), vinegar 0.1 g/L (0.14 g/L); Soft drinks and syrup: 0.1 (0.14); fruit sauce: 0.2 (0.28); fruits and vegetables 0.012 (0.016).

Hazards & Safety Information

Category :Toxic substances
Toxic classification: poisoning
Acute toxicity:  Oral-mouse LD50: 13200 mg/kg; celiac-mouse LD50: 230 mg/kg
Stimulation Data:  Skin-Guinea Pig 5%/48 hours Mild
Flammability and Hazardous characteristics:  Thermal decomposition; pungent irritation Smoke
Storage and transportation characteristics:  Treasury: ventilated, low temperature and dry
Fire extinguishing agent:  water, dry powder, foam, carbon dioxide

Chemical Properties

White or almost white, crystalline powder or colourless crystals.

Chemical Properties

Butylparaben occurs as colorless crystals or a white, crystalline, odorless or almost odorless, tasteless powder.

Uses

An antimicrobial

Uses

antifungal, preservative

Production Methods

Butylparaben is prepared by esterification of p-hydroxybenzoic acid with n-butanol.

General Description

Odorless white crystals or crystalline powder. Tasteless, but numbs the tongue. Aqueous solutions slightly acidic to litmus.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Butylparaben is incompatible with strong oxidizing agents and strong caustics.

Fire Hazard

Flash point data for Butylparaben are not available; however, Butylparaben is probably combustible.

Pharmaceutical Applications

Butylparaben is widely used as an antimicrobial preservative in cosmetics and pharmaceutical formulations.
It may be used either alone or in combination with other paraben esters or with other antimicrobial agents. In cosmetics, it is the fourth most frequently used preservative.
As a group, the parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds.
Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used in formulations. However, this may raise the pH of poorly buffered formulations. See Methylparaben for further information.

Contact allergens

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

Safety

Butylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics and oral and topical pharmaceutical formulations.
Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions generally appearing as contact dematitis. Immediate reactions with urticaria and bronchospasm have occurred rarely. See Methylparaben for further information.
LD50 (mouse, IP): 0.23 g/kg
LD50 (mouse, oral): 13.2 g/kg

storage

Aqueous butylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition. At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature).

Incompatibilities

The antimicrobial activity of butylparaben is considerably reduced in the presence of nonionic surfactants as a result of micellization. Absorption of butylparaben by plastics has not been reported but appears probable given the behavior of other parabens. Some pigments, e.g. ultramarine blue and yellow iron oxide, absorb butylparaben and thus reduce its preservative properties.
Butylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

Regulatory Status

Included in the FDA Inactive Ingredients Database (injections; oral capsules, solutions, suspensions, syrups and tablets; rectal, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Butylparaben Preparation Products And Raw materials

Raw materials

Preparation Products


Butylparaben Suppliers

Global( 309)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 748 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21954 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1730 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2236 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20095 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 4669 58

View Lastest Price from Butylparaben manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Butylparaben
94-26-8
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-08-14 Butylparaben
94-26-8
US $1.00 / KG 1KG 98% 1ton career henan chemical co

Butylparaben Spectrum


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