Ani9
- CAS No.
- 356102-14-2
- Chemical Name:
- Ani9
- Synonyms
- Ani9;2-(4-Chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide;Acetic acid, 2-(4-chloro-2-methylphenoxy)-, 2-[(2-methoxyphenyl)methylene]hydrazide
- CBNumber:
- CB54669000
- Molecular Formula:
- C17H17ClN2O3
- Molecular Weight:
- 332.78
- MDL Number:
- MFCD00635759
- MOL File:
- 356102-14-2.mol
Ani9 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1813 | Ani9 | 356102-14-2 | 5MG | $107 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1813 | Ani9 | 356102-14-2 | 25MG | $434 | 2023-06-20 | Buy |
| Cayman Chemical | 29733 | Ani 9 | 356102-14-2 | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 29733 | Ani 9 | 356102-14-2 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 29733 | Ani 9 | 356102-14-2 | 10mg | $197 | 2024-03-01 | Buy |
Ani9 Chemical Properties,Uses,Production
Description
Ani 9 is an inhibitor of the calcium-activated chloride channel (CaCC) anoctamin 1 (ANO1) that blocks ATP-induced apical membrane chloride currents in ANO1-expressing Fischer rat thyroid (FRT) cells (IC50 = 77 nM). It is selective for ANO1 over ANO2 at 10 μM and the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) at 30 μM. Ani 9 inhibits ATP-induced quenching of a fluorescent intracellular halide sensor in PC3 prostate cancer cells and Capan-1 pancreatic carcinoma cells in a concentration-dependent manner.
Uses
(4-Chloro-2-methylphenoxy)-[(2-methoxyphenyl)methylene]hydrazide Acetic Acid inhibits anoctamin1/transmembrane protein 16A, a calcium-activated chloride channel involved in fluid secretion, smooth muscle contraction, nociception and cancer progression.
Uses
Ani9 has been used to find out the inappropriate modulation of the membrane protein functions that are involved in the 198 ADGRG2- or Gq-mediated regulation of fluid reabsorption in the efferent ductules.
Biochem/physiol Actions
2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide (Ani9), the most potent inhibitor, is the structural analog of Ani7. It may be considered as a novel candidate for drug therapy of cancer, hypertension, pain, diarrhea and asthma.
storage
Store at -20°C
Ani9 Preparation Products And Raw materials
Raw materials
Preparation Products
Ani9 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3444 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |