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ChemicalBook >> CAS DataBase List >>N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358)

N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358)

N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358) Structure
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358) structure
CAS No.
1314212-39-9
Chemical Name:
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358)
Synonyms
CYM50358;CYM50358 >=98% (HPLC);N-(4-(Aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide;2-Furancarboxamide, N-[4-(aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-;N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358);CYM50358,LPL Receptor,Lysophospholipid Receptor,CYM-50358,Inhibitor,CYM 50358,inhibit,S1PR4
CBNumber:
CB54674301
Molecular Formula:
C20H18Cl2N2O2
Molecular Weight:
389.28
MDL Number:
MFCD28386025
MOL File:
1314212-39-9.mol
Last updated:2023-09-04 15:50:00
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N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358) Properties

Boiling point 463.5±45.0 °C(Predicted)
Density 1.329±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 125 mg/mL (321.11 mM; Need ultrasonic)
pka 12.40±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H319-H413
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P310-P321-P330-P405-P501

N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358) Chemical Properties,Uses,Production

Biological Activity

CYM50358 is a potent and selective S1PR4 antagonist, with an IC50 of 25 nM. CYM50358 can be used for the research of influenza infection[1][2]. CYM50358 shows less potent inhibition of S1PR1 (IC50=6.4 μM)[1].CYM50358 (10 μM) has no effect on the collagen-induced HSP27 phosphorylation, markedly reverses the suppressive effect of S1P on the collagen-induced phosphorylation of HSP27[2].

References

[1]. Guerrero M, et, al. Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3632-6. [2]. Onuma T, et, al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb Res. 2017 Aug;156:91-100.

N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358) Preparation Products And Raw materials

Raw materials

5-(2,5-DICHLORO-PHENYL)-FURAN-2-CARBONYL CHLORIDE Benzenemethanamine, 4-amino-3,5-dimethyl-

Preparation Products

N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358) Suppliers

Global( 13)Suppliers
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Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Adamas Reagent, Ltd. 400-6009262 16621234537 zhangsn@titansci.com China 14113 59
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4428 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 3444 55
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44894 58
Nantong Hi-Future Biotechnology Co., Ltd 18051384581 sales@chemhifuture.com China 2996 58
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Bide Pharmatech Ltd. 400-1647117 15221909166 product02@bidepharm.com China 61720 58
Supplier Advantage
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Adamas Reagent, Ltd. 59
Guangzhou Isun Pharmaceutical Co., Ltd 55
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Energy Chemical 58
Nantong Hi-Future Biotechnology Co., Ltd 58
Hefei Mokai Pharmaceutical Technology Co., Ltd 58
Bide Pharmatech Ltd. 58

N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358) Spectrum

N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358)(1314212-39-9)1HNMR

1314212-39-9(N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358))Related Search:

CYM50179 CYM50308 1-[2-(1-Benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxo-ethyl]-6-oxo-1,6-dihydro-pyridine-3-carbonitrile N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamide hydrochloride
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358) CYM50358 CYM50358 >=98% (HPLC) N-(4-(Aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide CYM50358,LPL Receptor,Lysophospholipid Receptor,CYM-50358,Inhibitor,CYM 50358,inhibit,S1PR4 2-Furancarboxamide, N-[4-(aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)- 1314212-39-9