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ARA-S

CAS No.
187224-29-9
Chemical Name:
ARA-S
Synonyms
ARA-S;N-ARACHIDONOYL L-SERINE;N-[1-OXO-(5Z,8Z,11Z,14Z-EICOSATETRAENYL)]-L-SERINE;L-Serine, N-[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]-
CBNumber:
CB5470587
Molecular Formula:
C23H37NO4
Molecular Weight:
391.54
MDL Number:
MFCD08062151
MOL File:
187224-29-9.mol
Last updated:2023-07-14 17:47:39

ARA-S Properties

Boiling point 607.6±55.0 °C(Predicted)
Density 1.027±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 2 mg/ml
pka 3.26±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS08
Signal word  Danger
Hazard statements  H225-H350
Precautionary statements  P201-P202-P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P308+P313-P370+P378-P403+P235-P405-P501
NFPA 704
3
0 0

ARA-S price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10005455 N-Arachidonoyl-L-Serine ≥98% 187224-29-9 1mg $20 2024-03-01 Buy
Cayman Chemical 10005455 N-Arachidonoyl-L-Serine ≥98% 187224-29-9 5mg $50 2024-03-01 Buy
Cayman Chemical 10005455 N-Arachidonoyl-L-Serine ≥98% 187224-29-9 10mg $74 2024-03-01 Buy
Cayman Chemical 10005455 N-Arachidonoyl-L-Serine ≥98% 187224-29-9 25mg $160 2024-03-01 Buy
TRC A765110 N-Arachidonoyl-L-serine 187224-29-9 100mg $395 2021-12-16 Buy
Product number Packaging Price Buy
10005455 1mg $20 Buy
10005455 5mg $50 Buy
10005455 10mg $74 Buy
10005455 25mg $160 Buy
A765110 100mg $395 Buy

ARA-S Chemical Properties,Uses,Production

Description

Arachidonoyl amides of both amino acids and neurotransmitters such as dopamine have been previously reported in the literature. N-Arachidonoyl-L-serine (ARA-S) is one such recently isolated endocannabinoid with an unusual activity profile. ARA-S does not bind to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors or vanilloid receptor 1 (VR1). Like cannabidiol, ARA-S (5 mg/kg) antagonizes the hypotensive effects of a 10 mg/kg IV bolus of abnormal cannabidiol (Abn-CBD) in an anesthetized rat blood pressure model. However, similar to Abn-CBD, ARA-S relaxes isolated rat mesenteric arteries and abdominal aorta as well as increases phosphorylation of Akt and mitogen-activated protein kinase (MAPK) in HUVEC. The precise mechanisms of action by ARA-S and Abn-DBD in various vascular preparations appears to be different and requires further investigation.

Uses

N-Arachidonoyl-L-serine is a novel neuroprotective endocannabinoid with weak affinity for CB1 and CB2 cannabinoid receptors. It is also a pro-angiogenic factor and a vessel dilator. Shows proneurogenic properties in vitro and invivo in mice model of traumatic brain injury. (1) Exhibits neuroprotection via ERK and Akt phosphorylation and induction of their downstream antiapoptotic pathways (2)

Definition

ChEBI: N-arachidonoyl-L-serine is an N-acyl-amino acid resulting from the formal condensation of the carboxy group of arachidonic acid with the amino group of L-serine. It is an endocannabinoid-like lipid isolated from bovine brains. It has a role as a cannabinoid receptor agonist, a vasodilator agent, a pro-angiogenic agent, a neuroprotective agent and a mammalian metabolite. It is functionally related to an arachidonic acid and a L-serine. It is a conjugate acid of a N-arachidonoyl-L-serine(1-).

ARA-S Preparation Products And Raw materials

Raw materials

Preparation Products

ARA-S Suppliers

Global( 28)Suppliers
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Alfa Chemistry
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Aladdin Scientific
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ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
N-ARACHIDONOYL L-SERINE N-[1-OXO-(5Z,8Z,11Z,14Z-EICOSATETRAENYL)]-L-SERINE ARA-S L-Serine, N-[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]- 187224-29-9 Cannabinoid receptor