TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT
- CAS No.
- 94825-57-7
- Chemical Name:
- TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT
- Synonyms
- (D-alanine2,D-leucine5)enkephalin;(D-ALA2, D-LEU5)-ENKEPHALIN ACETATE;TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT;[D-ALA2, D-LEU5]-ENKEPHALIN ACETATE SALT;[D-Ala2, D-Leu5]-Enkephalin acetate salt,DADLE;(2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
- CBNumber:
- CB5472798
- Molecular Formula:
- C31H43N5O9
- Molecular Weight:
- 629.71
- MDL Number:
- MFCD00133947
- MOL File:
- 94825-57-7.mol
TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E7131 | [D-Ala2, D-Leu5]-Enkephalin acetate salt ≥95% (HPLC) | 94825-57-7 | 1mg | $36.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | E7131 | [D-Ala2, D-Leu5]-Enkephalin acetate salt ≥95% (HPLC) | 94825-57-7 | 5mg | $111 | 2024-03-01 | Buy |
| Sigma-Aldrich | E7131 | [D-Ala2, D-Leu5]-Enkephalin acetate salt ≥95% (HPLC) | 94825-57-7 | 25mg | $400 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | PEP0004633 | [D-ALA2,D-LEU5]-ENKEPHALIN ACETATE 95.00% | 94825-57-7 | 1MG | $632.81 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0004633 | [D-ALA2,D-LEU5]-ENKEPHALIN ACETATE 95.00% | 94825-57-7 | 5MG | $714.53 | 2021-12-16 | Buy |
TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT Chemical Properties,Uses,Production
Uses
[D-Ala2, D-Leu5]-Enkephalin or DADLE has been used for use in immunocomplex kinetic assay, to determine the activation of p70s6k by DADLE in the cell clones D2 and DOE and in non-transfected parental Rat-1 fibroblasts and to assess the analgesic effect of WIN55,212-2 in mice.
General Description
[D-Ala2, D-Leu5]-Enkephalin acetate salt, also called DADLE, is an analog of endogenous δ-opioid peptide encephalin, and is metabolically stable.
Biochem/physiol Actions
[D-Ala2, D-Leu5]-Enkephalin can induce hibernation in ground squirrels, during summers, when they do not normally hibernate. In multiorgan block preparation, it can prolong the survival time of organs such as, heart, lung, liver, spleen and kidney, up to 46hrs. It aids in tolerance development of myocardium to ischemia. It might have tissue protective role in central nervous system. It prevents and reverses methamphetamine (METH)-induced damage of dopaminergic terminals of brain. It prevents naltrexone-sensitive PC12 cell apoptosis in serum deprivation conditions. Thus, it might play an essential role in the survival of neurons and organs.
TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT Preparation Products And Raw materials
Raw materials
Preparation Products
TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| Guangzhou Isun Pharmaceutical Co., Ltd | 55 |
| Sigma-Aldrich | 80 |